| Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms DE Gordon, J Hiatt, M Bouhaddou, VV Rezelj, S Ulferts, H Braberg, ... Science 370 (6521), eabe9403, 2020 | 631 | 2020 |
| Structural analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements AK Shiau, SF Harris, DR Southworth, DA Agard Cell 127 (2), 329-340, 2006 | 561 | 2006 |
| Glucocorticoid receptor function regulated by coordinated action of the Hsp90 and Hsp70 chaperone cycles E Kirschke, D Goswami, D Southworth, PR Griffin, DA Agard Cell 157 (7), 1685-1697, 2014 | 445 | 2014 |
| Species-dependent ensembles of conserved conformational states define the Hsp90 chaperone ATPase cycle DR Southworth, DA Agard Molecular cell 32 (5), 631-640, 2008 | 271 | 2008 |
| Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104 SN Gates, AL Yokom, JB Lin, ME Jackrel, AN Rizo, NM Kendsersky, ... Science 357 (6348), 273-279, 2017 | 258 | 2017 |
| Mutational analysis of S12 protein and implications for the accuracy of decoding by the ribosome D Sharma, AR Cukras, EJ Rogers, DR Southworth, R Green Journal of molecular biology 374 (4), 1065-1076, 2007 | 191 | 2007 |
| Client-loading conformation of the Hsp90 molecular chaperone revealed in the cryo-EM structure of the human Hsp90: Hop complex DR Southworth, DA Agard Molecular cell 42 (6), 771-781, 2011 | 186 | 2011 |
| Ribosomal proteins S12 and S13 function as control elements for translocation of the mRNA: tRNA complex AR Cukras, DR Southworth, JL Brunelle, GM Culver, R Green Molecular cell 12 (2), 321-328, 2003 | 148 | 2003 |
| Polyphosphate: a conserved modifier of amyloidogenic processes CM Cremers, D Knoefler, S Gates, N Martin, JU Dahl, J Lempart, L Xie, ... Molecular cell 63 (5), 768-780, 2016 | 139 | 2016 |
| BAG3 is a modular, scaffolding protein that physically links heat shock protein 70 (Hsp70) to the small heat shock proteins JN Rauch, E Tse, R Freilich, SA Mok, LN Makley, DR Southworth, ... Journal of molecular biology 429 (1), 128-141, 2017 | 138 | 2017 |
| Specific binding of tetratricopeptide repeat proteins to heat shock protein 70 (Hsp70) and heat shock protein 90 (Hsp90) is regulated by affinity and phosphorylation VA Assimon, DR Southworth, JE Gestwicki Biochemistry 54 (48), 7120-7131, 2015 | 122 | 2015 |
| Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation JJ Chen, DL Nathaniel, P Raghavan, M Nelson, R Tian, E Tse, JY Hong, ... Journal of Biological Chemistry 294 (50), 18952-18966, 2019 | 118 | 2019 |
| Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation AL Yokom, SN Gates, ME Jackrel, KL Mack, M Su, J Shorter, ... Nature structural & molecular biology 23 (9), 830-837, 2016 | 115 | 2016 |
| Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase AN Rizo, JB Lin, SN Gates, E Tse, SM Bart, LM Castellano, F DiMaio, ... Nature communications 10 (1), 2393, 2019 | 100 | 2019 |
| EF-G-independent reactivity of a pre-translocation-state ribosome complex with the aminoacyl tRNA substrate puromycin supports an intermediate (hybrid) state of tRNA binding D Sharma, DR Southworth, R Green Rna 10 (1), 102-113, 2004 | 99 | 2004 |
| Spiraling in control: structures and mechanisms of the Hsp104 disaggregase J Shorter, DR Southworth Cold Spring Harbor perspectives in biology 11 (8), a034033, 2019 | 93 | 2019 |
| KRAS protein stability is regulated through SMURF2: UBCH5 complex-mediated β-TrCP1 degradation S Shukla, US Allam, A Ahsan, G Chen, PM Krishnamurthy, K Marsh, ... Neoplasia 16 (2), 115-W5, 2014 | 93 | 2014 |
| Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau R Freilich, M Betegon, E Tse, SA Mok, O Julien, DA Agard, ... Nature communications 9 (1), 4563, 2018 | 91 | 2018 |
| Mitochondrial peroxiredoxin functions as crucial chaperone reservoir in Leishmania infantum F Teixeira, H Castro, T Cruz, E Tse, P Koldewey, DR Southworth, ... Proceedings of the National Academy of Sciences 112 (7), E616-E624, 2015 | 91 | 2015 |
| The conserved arginine 380 of Hsp90 is not a catalytic residue, but stabilizes the closed conformation required for ATP hydrolysis CN Cunningham, DR Southworth, KA Krukenberg, DA Agard Protein Science 21 (8), 1162-1171, 2012 | 82 | 2012 |
