Synthesis of tamiflu and its phosphonate congeners possessing potent anti-influenza activity JJ Shie, JM Fang, SY Wang, KC Tsai, YSE Cheng, AS Yang, SC Hsiao, ... Journal of the American Chemical Society 129 (39), 11892-11893, 2007 | 252 | 2007 |
Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease IL Lu, N Mahindroo, PH Liang, YH Peng, CJ Kuo, KC Tsai, HP Hsieh, ... Journal of medicinal chemistry 49 (17), 5154-5161, 2006 | 182 | 2006 |
Discovery of Highly Potent Tyrosinase Inhibitor, T1, with Significant Anti-Melanogenesis Ability by zebrafish in vivo Assay and Computational Molecular Modeling WC Chen, TS Tseng, NW Hsiao, YL Lin, ZH Wen, CC Tsai, YC Lee, ... Scientific Reports 5 (1), 7995, 2015 | 169 | 2015 |
A practical synthesis of zanamivir phosphonate congeners with potent anti-influenza activity JJ Shie, JM Fang, PT Lai, WH Wen, SY Wang, YSE Cheng, KC Tsai, ... Journal of the American Chemical Society 133 (44), 17959-17965, 2011 | 97 | 2011 |
Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies KC Tsai, SY Chen, PH Liang, IL Lu, N Mahindroo, HP Hsieh, YS Chao, ... Journal of medicinal chemistry 49 (12), 3485-3495, 2006 | 96 | 2006 |
Construction of a 3D model of nattokinase, a novel fibrinolytic enzyme from Bacillus natto: a novel nucleophilic catalytic mechanism for nattokinase Z Zheng, Z Zuo, Z Liu, K Tsai, A Liu, G Zou Journal of Molecular Graphics and Modelling 23 (4), 373-380, 2005 | 89 | 2005 |
Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease YM Shao, WB Yang, TH Kuo, KC Tsai, CH Lin, AS Yang, PH Liang, ... Bioorganic & medicinal chemistry 16 (8), 4652-4660, 2008 | 84 | 2008 |
A comparison of different electrostatic potentials on prediction accuracy in CoMFA and CoMSIA studies KC Tsai, YC Chen, NW Hsiao, CL Wang, CL Lin, YC Lee, M Li, B Wang European Journal of Medicinal Chemistry 45 (4), 1544-1551, 2010 | 80 | 2010 |
A traditional Chinese medicine formula NRICM101 to target COVID-19 through multiple pathways: A bedside-to-bench study KC Tsai, YC Huang, CC Liaw, CI Tsai, CT Chiou, CJ Lin, WC Wei, SJS Lin, ... Biomedicine & Pharmacotherapy 133, 111037, 2021 | 76 | 2021 |
Structure and immunological characterization of the capsular polysaccharide of a pyrogenic liver abscess caused by Klebsiella pneumoniae: activation of macrophages through Toll … FL Yang, YL Yang, PC Liao, JC Chou, KC Tsai, AS Yang, F Sheu, TL Lin, ... Journal of Biological Chemistry 286 (24), 21041-21051, 2011 | 72 | 2011 |
Implementing the Fisher's Discriminant Ratio in a k-Means Clustering Algorithm for Feature Selection and Data Set Trimming TH Lin, HT Li, KC Tsai Journal of chemical information and computer sciences 44 (1), 76-87, 2004 | 63 | 2004 |
Analogs of zanamivir with modified C4-substituents as the inhibitors against the group-1 neuraminidases of influenza viruses WH Wen, SY Wang, KC Tsai, YSE Cheng, AS Yang, JM Fang, CH Wong Bioorganic & medicinal chemistry 18 (11), 4074-4084, 2010 | 62 | 2010 |
Rationalization and design of the complementarity determining region sequences in an antibody-antigen recognition interface CM Yu, HP Peng, IC Chen, YC Lee, JB Chen, KC Tsai, CT Chen, ... PLoS One 7 (3), e33340, 2012 | 61 | 2012 |
Bioactivity-guided screening identifies pheophytin a as a potent anti-hepatitis C virus compound from Lonicera hypoglauca Miq. SY Wang, CP Tseng, KC Tsai, CF Lin, CY Wen, HS Tsay, N Sakamoto, ... Biochemical and Biophysical Research Communications 385 (2), 230-235, 2009 | 59 | 2009 |
The pharmacophore hypotheses of IKr potassium channel blockers: novel class III antiarrhythmic agents LP Du, KC Tsai, MY Li, QD You, L Xia Bioorganic & medicinal chemistry letters 14 (18), 4771-4777, 2004 | 56 | 2004 |
Inhibition of CYP1 by berberine, palmatine, and jatrorrhizine: selectivity, kinetic characterization, and molecular modeling SN Lo, YP Chang, KC Tsai, CY Chang, TS Wu, YF Ueng Toxicology and applied pharmacology 272 (3), 671-680, 2013 | 51 | 2013 |
Serendipitous discovery of short peptides from natural products as tyrosinase inhibitors NW Hsiao, TS Tseng, YC Lee, WC Chen, HH Lin, YR Chen, YT Wang, ... Journal of chemical information and modeling 54 (11), 3099-3111, 2014 | 49 | 2014 |
Development of GlcNAc-Inspired Iminocyclitiols as Potent and Selective N-Acetyl-β-Hexosaminidase Inhibitors CW Ho, SD Popat, TW Liu, KC Tsai, MJ Ho, WH Chen, AS Yang, CH Lin ACS Chemical Biology 5 (5), 489-497, 2010 | 49 | 2010 |
How to generate reliable and predictive CoMFA models L Zhang, KC Tsai, L Du, H Fang, M Li, W Xu Current medicinal chemistry 18 (6), 923-930, 2011 | 48 | 2011 |
The effect of different electrostatic potentials on docking accuracy: a case study using DOCK5. 4 KC Tsai, SH Wang, NW Hsiao, M Li, B Wang Bioorganic & medicinal chemistry letters 18 (12), 3509-3512, 2008 | 46 | 2008 |