Cubane: 50 years later KF Biegasiewicz, JR Griffiths, GP Savage, J Tsanaktsidis, R Priefer Chemical reviews 115 (14), 6719-6745, 2015 | 179 | 2015 |
Validating Eaton's hypothesis: Cubane as a benzene bioisostere BA Chalmers, H Xing, S Houston, C Clark, S Ghassabian, A Kuo, B Cao, ... Angewandte Chemie International Edition 55 (11), 3580-3585, 2016 | 155 | 2016 |
Cycloaddition reactions of nitrile oxides with alkenes CJ Easton, CMM Hughes, GP Savage, GW Simpson Advances in Heterocyclic Chemistry 60, 261-327, 1994 | 97 | 1994 |
Total synthesis of the potent anticancer Aglaia metabolites (−)-silvestrol and (−)-episilvestrol and the active analogue (−)-4′-desmethoxyepisilvestrol TE Adams, M El Sous, BC Hawkins, S Hirner, G Holloway, ML Khoo, ... Journal of the American Chemical Society 131 (4), 1607-1616, 2009 | 88 | 2009 |
Nonclassical phenyl bioisosteres as effective replacements in a series of novel open-source antimalarials EG Tse, SD Houston, CM Williams, GP Savage, LM Rendina, ... Journal of Medicinal Chemistry 63 (20), 11585-11601, 2020 | 82 | 2020 |
A Concise Route to Dihydrobenzo[b]furans: Formal Total Synthesis of (+)-Lithospermic Acid J Fischer, GP Savage, MJ Coster Organic Letters 13 (13), 3376-3379, 2011 | 82 | 2011 |
Methyllycaconitine analogues have mixed antagonist effects at nicotinic acetylcholine receptors D Barker, DHS Lin, JE Carland, CPY Chu, M Chebib, MA Brimble, ... Bioorganic & medicinal chemistry 13 (14), 4565-4575, 2005 | 71 | 2005 |
Synthesis of biotinylated episilvestrol: highly selective targeting of the translation factors eIF4AI/II JM Chambers, LM Lindqvist, A Webb, DCS Huang, GP Savage, ... Organic letters 15 (6), 1406-1409, 2013 | 70 | 2013 |
The direct α-C (sp 3)–H functionalisation of N-aryl tetrahydroisoquinolines via an iron-catalysed aerobic nitro-Mannich reaction and continuous flow processing M Brzozowski, JA Forni, GP Savage, A Polyzos Chemical communications 51 (2), 334-337, 2015 | 69 | 2015 |
Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker YW Cheung, P Röthlisberger, AE Mechaly, P Weber, F Levi-Acobas, Y Lo, ... Proceedings of the National Academy of Sciences 117 (29), 16790-16798, 2020 | 66 | 2020 |
Reducing the cost, smell, and toxicity of the Barton reductive decarboxylation: Chloroform as the hydrogen atom source EJ Ko, GP Savage, CM Williams, J Tsanaktsidis Organic Letters 13 (8), 1944-1947, 2011 | 64 | 2011 |
Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design TS Peat, DI Rhodes, N Vandegraaff, G Le, JA Smith, LJ Clark, ED Jones, ... PloS one 7 (7), e40147, 2012 | 62 | 2012 |
The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement SD Houston, T Fahrenhorst-Jones, H Xing, BA Chalmers, ML Sykes, ... Organic & Biomolecular Chemistry 17 (28), 6790-6798, 2019 | 61 | 2019 |
Pilot-scale production of dimethyl 1, 4-cubanedicarboxylate MJ Falkiner, SW Littler, KJ McRae, GP Savage, J Tsanaktsidis Organic Process Research & Development 17 (12), 1503-1509, 2013 | 60 | 2013 |
Structural Basis for a New Mechanism of Inhibition of HI V-1 Integrase Identified by Fragment Screening and Structure-Based Design DI Rhodes, TS Peat, N Vandegraaff, D Jeevarajah, G Le, ED Jones, ... Antiviral Chemistry and Chemotherapy 21 (4), 155-168, 2011 | 57 | 2011 |
Spiro isoxazolines via nitrile oxide 1, 3-dipolar cycloaddition reactions GP Savage Curr. Org. Chem 14, 1478-1499, 2010 | 56 | 2010 |
Reversal of regiochemistry in the synthesis of isoxazoles by nitrile oxide cycloadditions CJ Easton, CM Hughes, ERT Tiekink, CE Lubin, GP Savage, ... Tetrahedron letters 35 (21), 3589-3592, 1994 | 48 | 1994 |
Chloroform as a hydrogen atom donor in Barton reductive decarboxylation reactions J Ho, J Zheng, R Meana-Pañeda, DG Truhlar, EJ Ko, GP Savage, ... The Journal of Organic Chemistry 78 (13), 6677-6687, 2013 | 46 | 2013 |
The cyclic structure of 2-iodosyl-and 2-iodyl-benzoic acid anions: a basicity and X-ray crystallographic study G PauláSavage, H DupontáDurst Journal of the Chemical Society, Perkin Transactions 2, 1657-1661, 1990 | 42 | 1990 |
An enantioselective total synthesis of the stilbenolignan (−)-aiphanol and the determination of its absolute stereochemistry MG Banwell, S Chand, GP Savage Tetrahedron: Asymmetry 16 (9), 1645-1654, 2005 | 39 | 2005 |