PDK4 drives metabolic alterations and muscle atrophy in cancer cachexia F Pin, LJ Novinger, JR Huot, RA Harris, ME Couch, TM O’Connell, ... The FASEB Journal 33 (6), 7778, 2019 | 63 | 2019 |
Bisphosphonate treatment ameliorates chemotherapy-induced bone and muscle abnormalities in young mice AL Essex, F Pin, JR Huot, LF Bonewald, LI Plotkin, A Bonetto Frontiers in Endocrinology 10, 809, 2019 | 47 | 2019 |
HCT116 colorectal liver metastases exacerbate muscle wasting in a mouse model for the study of colorectal cancer cachexia JR Huot, LJ Novinger, F Pin, A Bonetto Disease models & mechanisms 13 (1), dmm043166, 2020 | 36 | 2020 |
ACVR2B antagonism as a countermeasure to multi‐organ perturbations in metastatic colorectal cancer cachexia JR Huot, F Pin, A Narasimhan, LJ Novinger, AS Keith, TA Zimmers, ... Journal of cachexia, sarcopenia and muscle 11 (6), 1779-1798, 2020 | 35 | 2020 |
Muscle weakness caused by cancer and chemotherapy is associated with loss of motor unit connectivity JR Huot, F Pin, A Bonetto American journal of cancer research 11 (6), 2990, 2021 | 30 | 2021 |
Chronic treatment with multi-kinase inhibitors causes differential toxicities on skeletal and cardiac muscles JR Huot, AL Essex, M Gutierrez, R Barreto, M Wang, DL Waning, ... Cancers 11 (4), 571, 2019 | 30 | 2019 |
Treatment with treprostinil and metformin normalizes hyperglycemia and improves cardiac function in pulmonary hypertension associated with heart failure with preserved ejection … L Wang, G Halliday, JR Huot, T Satoh, JJ Baust, A Fisher, T Cook, J Hu, ... Arteriosclerosis, thrombosis, and vascular biology 40 (6), 1543-1558, 2020 | 29 | 2020 |
Reduced rDNA transcription diminishes skeletal muscle ribosomal capacity and protein synthesis in cancer cachexia HG Kim, JR Huot, F Pin, B Guo, A Bonetto, GA Nader FASEB journal: official publication of the Federation of American Societies …, 2021 | 28 | 2021 |
Formation of colorectal liver metastases induces musculoskeletal and metabolic abnormalities consistent with exacerbated cachexia JR Huot, LJ Novinger, F Pin, A Narasimhan, TA Zimmers, TM O’Connell, ... JCI insight 5 (9), 2020 | 25 | 2020 |
MC38 tumors induce musculoskeletal defects in colorectal cancer JR Huot, F Pin, AL Essex, A Bonetto International Journal of Molecular Sciences 22 (3), 1486, 2021 | 24 | 2021 |
Acute sodium ingestion before exercise increases voluntary water consumption resulting in preexercise hyperhydration and improvement in exercise performance in the heat DM Morris, JR Huot, AM Jetton, SR Collier, AC Utter International journal of sport nutrition and exercise metabolism 25 (5), 456-462, 2015 | 24 | 2015 |
The mitochondria-targeting agent MitoQ improves muscle atrophy, weakness and oxidative metabolism in C26 tumor-bearing mice F Pin, JR Huot, A Bonetto Frontiers in cell and developmental biology 10, 861622, 2022 | 23 | 2022 |
RANKL blockade reduces cachexia and bone loss induced by non‐metastatic ovarian cancer in mice F Pin, AJ Jones, JR Huot, A Narasimhan, TA Zimmers, LF Bonewald, ... Journal of Bone and Mineral Research 37 (3), 381-396, 2020 | 17 | 2020 |
Non-bone metastatic cancers promote osteocyte-induced bone destruction F Pin, M Prideaux, JR Huot, AL Essex, LI Plotkin, A Bonetto, LF Bonewald Cancer letters 520, 80-90, 2021 | 16 | 2021 |
PGC1α overexpression preserves muscle mass and function in cisplatin‐induced cachexia JR Huot, F Pin, R Chatterjee, A Bonetto Journal of Cachexia, Sarcopenia and Muscle 13 (5), 2480-2491, 2022 | 14 | 2022 |
Mice lacking PKC-θ in skeletal muscle have reduced intramyocellular lipid accumulation and increased insulin responsiveness in skeletal muscle B Peck, J Huot, T Renzi, S Arthur, MJ Turner, JS Marino American Journal of Physiology-Regulatory, Integrative and Comparative …, 2018 | 14 | 2018 |
Current thoughts of notch’s role in myoblast regulation and muscle-associated disease JC Gerrard, JP Hay, RN Adams, JC Williams III, JR Huot, KM Weathers, ... International Journal of Environmental Research and Public Health 18 (23), 12558, 2021 | 13 | 2021 |
Targeting mitochondria and oxidative stress in cancer-and chemotherapy-induced muscle wasting JR Huot, D Baumfalk, A Resendiz, A Bonetto, AJ Smuder, F Penna Antioxidants & Redox Signaling 38 (4), 352-370, 2023 | 12 | 2023 |
Metabolic health and disease: a role of Osteokines? A Shimonty, LF Bonewald, JR Huot Calcified Tissue International 113 (1), 21-38, 2023 | 10 | 2023 |
Triggering receptor expressed on myeloid cells 2 (TREM2) R47H variant causes distinct age‐and sex‐dependent musculoskeletal alterations in mice AL Essex, JR Huot, P Deosthale, A Wagner, J Figueras, A Davis, ... Journal of Bone and Mineral Research 37 (7), 1366-1381, 2020 | 10 | 2020 |