LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same DC Berwick, GR Heaton, S Azeggagh, K Harvey Molecular Neurodegeneration 14, 1-22, 2019 | 147 | 2019 |
Back to the tubule: microtubule dynamics in Parkinson’s disease L Pellegrini, A Wetzel, S Grannó, G Heaton, K Harvey Cellular and Molecular Life Sciences 74, 409-434, 2017 | 143 | 2017 |
Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice L Pellegrini, DN Hauser, Y Li, A Mamais, A Beilina, R Kumaran, A Wetzel, ... Human molecular genetics 27 (18), 3257-3271, 2018 | 62 | 2018 |
Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia A Mamais, JH Kluss, L Bonet-Ponce, N Landeck, RG Langston, N Smith, ... PLoS biology 19 (12), e3001480, 2021 | 52 | 2021 |
Progress in LRRK2-Associated Parkinson’s Disease Animal Models SP Seegobin, GR Heaton, D Liang, I Choi, M Blanca Ramirez, B Tang, ... Frontiers in Neuroscience 14, 674, 2020 | 39 | 2020 |
Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis GR Heaton, N Landeck, A Mamais, MA Nalls, J Nixon-Abell, R Kumaran, ... Neurobiology of disease 141, 104948, 2020 | 34 | 2020 |
Downregulated Wnt/β-catenin signalling in the Down syndrome hippocampus S Granno, J Nixon-Abell, DC Berwick, J Tosh, G Heaton, S Almudimeegh, ... Scientific reports 9 (1), 7322, 2019 | 32 | 2019 |
Ocular biomarkers of Alzheimer’s disease G R Heaton, B M Davis, L A Turner, M F Cordeiro Central Nervous System Agents in Medicinal Chemistry (Formerly Current …, 2015 | 21 | 2015 |
Regulation of α-synuclein homeostasis and inflammasome activation by microglial autophagy I Choi, GR Heaton, YK Lee, Z Yue Science advances 8 (43), eabn1298, 2022 | 19 | 2022 |
Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders CM Wilk, F Cathomas, O Török, J Le Berichel, MD Park, C Bigenwald, ... Immunity 56 (12), 2790-2802. e6, 2023 | 8 | 2023 |
Correction: Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia A Mamais, JH Kluss, L Bonet-Ponce, N Landeck, RG Langston, N Smith, ... Plos Biology 20 (5), e3001621, 2022 | 2 | 2022 |
Circulating senescent myeloid cells drive blood brain barrier breakdown and neurodegeneration CM Wilk, F Cathomas, O Torok, J Le Berichel, MD Park, GR Heaton, ... bioRxiv, 2023.10. 10.561744, 2023 | 1 | 2023 |
Bone Marrow-Derived BRAFV600E-Mutated Cells Drive Neurodegeneration in a Mouse Model of Langerhans Cell Histiocytosis CM Wilk, J LeBerichel, F Cathomas, G Heaton, O Török, A Silvin, Z Yue, ... Blood 140 (Supplement 1), 3873-3873, 2022 | | 2022 |
Mutations in LRRK2 linked to Parkinson disease sequester Rab8a to damaged lysosomes and regulate transferrin-mediated iron uptake in microglia (vol 19, 3001480, 2021) A Mamais, JH Kluss, L Bonet-Ponce, N Landeck, RG Langston, N Smith, ... PLOS BIOLOGY 20 (5), 2022 | | 2022 |
Investigating vesicular trafficking function and dysfunction of the Parkinson’s Disease kinase LRRK2 G Heaton UCL (University College London), 2019 | | 2019 |