| Fragment-based covalent ligand discovery W Lu, M Kostic, T Zhang, J Che, MP Patricelli, LH Jones, ET Chouchani, ... RSC chemical biology 2 (2), 354-367, 2021 | 93 | 2021 |
| Discovery and resistance mechanism of a selective CDK12 degrader B Jiang, Y Gao, J Che, W Lu, IH Kaltheuner, R Dries, M Kalocsay, ... Nature chemical biology 17 (6), 675-683, 2021 | 81 | 2021 |
| Computer-aided drug design in epigenetics W Lu, R Zhang, H Jiang, H Zhang, C Luo Frontiers in chemistry 6, 57, 2018 | 71 | 2018 |
| Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors W Lu, J Wang, Y Li, H Tao, H Xiong, F Lian, J Gao, H Ma, T Lu, D Zhang, ... European Journal of Medicinal Chemistry 184, 111767, 2019 | 65 | 2019 |
| A patent review of BRD4 inhibitors (2013-2019) T Lu, W Lu, C Luo Expert Opinion on Therapeutic Patents, 2020 | 47 | 2020 |
| Machine-learning-assisted approach for discovering novel inhibitors targeting bromodomain-containing protein 4 J Xing, W Lu, R Liu, Y Wang, Y Xie, H Zhang, Z Shi, H Jiang, YC Liu, ... Journal of Chemical Information and Modeling 57 (7), 1677-1690, 2017 | 44 | 2017 |
| Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins D Chen, T Lu, Z Yan, W Lu, F Zhou, X Lyu, B Xu, H Jiang, K Chen, C Luo, ... European Journal of Medicinal Chemistry 182, 111633, 2019 | 39 | 2019 |
| Discovery of 1, 8-acridinedione derivatives as novel GCN5 inhibitors via high throughput screening H Xiong, J Han, J Wang, W Lu, C Wang, Y Chen, F Lian, N Zhang, YC Liu, ... European journal of medicinal chemistry 151, 740-751, 2018 | 36 | 2018 |
| Discovery of a potent degrader for fibroblast growth factor receptor 1/2 G Du, J Jiang, Q Wu, NJ Henning, KA Donovan, H Yue, J Che, W Lu, ... Angewandte Chemie 133 (29), 16041-16047, 2021 | 32 | 2021 |
| Design, synthesis, and biological evaluation of novel DNA gyrase-inhibiting spiropyrimidinetriones as potent antibiotics for treatment of infections caused by multidrug … C Shi, Y Zhang, T Wang, W Lu, S Zhang, B Guo, Q Chen, C Luo, X Zhou, ... Journal of Medicinal Chemistry 62 (6), 2950-2973, 2019 | 30 | 2019 |
| Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling M Fan, W Lu, J Che, NP Kwiatkowski, Y Gao, HS Seo, SB Ficarro, ... Elife 11, e78810, 2022 | 27 | 2022 |
| Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3 T Lu, Y Li, W Lu, T Spitters, X Fang, J Wang, S Cai, J Gao, Y Zhou, Z Duan, ... Acta Pharmaceutica Sinica B 11 (10), 3206-3219, 2021 | 25 | 2021 |
| Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors W Lu, H Xiong, Y Chen, C Wang, H Zhang, P Xu, J Han, S Xiao, H Ding, ... Bioorganic & Medicinal Chemistry 26 (20), 5397-5407, 2018 | 24 | 2018 |
| Identification of small molecule inhibitors targeting the SMARCA2 bromodomain from a high-throughput screening assay T Lu, J Hu, W Lu, J Han, H Ding, H Jiang, Y Zhang, L Yue, S Chen, ... Acta Pharmacologica Sinica 39 (9), 1544-1552, 2018 | 23 | 2018 |
| Development of PDE6D and CK1α degraders through chemical derivatization of FPFT-2216 M Teng, W Lu, KA Donovan, J Sun, NM Krupnick, RP Nowak, YD Li, ... Journal of medicinal chemistry 65 (1), 747-756, 2021 | 22 | 2021 |
| BRD4 as a therapeutic target for nonfunctioning and growth hormone pituitary adenoma C Shi, Z Ye, J Han, X Ye, W Lu, C Ji, Z Li, Z Ma, Q Zhang, Y Zhang, W He, ... Neuro-oncology 22 (8), 1114-1125, 2020 | 22 | 2020 |
| Phospholipid-mimic oxaliplatin prodrug liposome for treatment of the metastatic triple negative breast cancer B Feng, F Zhou, W Lu, D Wang, T Wang, C Luo, H Wang, Y Li, H Yu Biomaterials science 5 (8), 1522-1525, 2017 | 22 | 2017 |
| Identification of novel EZH2 inhibitors through pharmacophore-based virtual screening and biological assays Y Wu, J Hu, H Ding, L Chen, Y Zhang, R Liu, P Xu, D Du, W Lu, J Liu, ... Bioorganic & Medicinal Chemistry Letters 26 (15), 3813-3817, 2016 | 18 | 2016 |
| Covalent inhibitors allosterically block the activation of rho family proteins and suppress cancer cell invasion Z Sun, H Zhang, Y Zhang, L Liao, W Zhou, F Zhang, F Lian, J Huang, P Xu, ... Advanced Science 7 (14), 2000098, 2020 | 17 | 2020 |
| Discovery of alkoxy benzamide derivatives as novel BPTF bromodomain inhibitors via structure-based virtual screening D Zhang, J Han, W Lu, F Lian, J Wang, T Lu, H Tao, S Xiao, F Zhang, ... Bioorganic chemistry 86, 494-500, 2019 | 17 | 2019 |
