| 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks SF Bunting, E Callén, N Wong, HT Chen, F Polato, A Gunn, A Bothmer, ... Cell 141 (2), 243-254, 2010 | 1823 | 2010 |
| Genomic instability in mice lacking histone H2AX A Celeste, S Petersen, PJ Romanienko, O Fernandez-Capetillo, HT Chen, ... Science 296 (5569), 922-927, 2002 | 1716 | 2002 |
| H2AX: the histone guardian of the genome O Fernandez-Capetillo, A Lee, M Nussenzweig, A Nussenzweig DNA repair 3 (8-9), 959-967, 2004 | 1299 | 2004 |
| Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks A Celeste, O Fernandez-Capetillo, MJ Kruhlak, DR Pilch, DW Staudt, ... Nature cell biology 5 (7), 675-679, 2003 | 1278 | 2003 |
| A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity RM Marión, K Strati, H Li, M Murga, R Blanco, S Ortega, ... Nature 460 (7259), 1149-1153, 2009 | 1219 | 2009 |
| Replication fork stability confers chemoresistance in BRCA-deficient cells A Ray Chaudhuri, E Callen, X Ding, E Gogola, AA Duarte, JE Lee, ... Nature 535 (7612), 382-387, 2016 | 849 | 2016 |
| DNA damage-induced G2–M checkpoint activation by histone H2AX and 53BP1 O Fernandez-Capetillo, HT Chen, A Celeste, I Ward, PJ Romanienko, ... Nature cell biology 4 (12), 993-997, 2002 | 838 | 2002 |
| Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer D Herranz, M Muñoz-Martin, M Cañamero, F Mulero, B Martinez-Pastor, ... Nature communications 1 (1), 3, 2010 | 714 | 2010 |
| H2AX haploinsufficiency modifies genomic stability and tumor susceptibility A Celeste, S Difilippantonio, MJ Difilippantonio, O Fernandez-Capetillo, ... Cell 114 (3), 371-383, 2003 | 674 | 2003 |
| H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis O Fernandez-Capetillo, SK Mahadevaiah, A Celeste, PJ Romanienko, ... Developmental cell 4 (4), 497-508, 2003 | 670 | 2003 |
| Silencing of unsynapsed meiotic chromosomes in the mouse JMA Turner, SK Mahadevaiah, O Fernandez-Capetillo, A Nussenzweig, ... Nature genetics 37 (1), 41-47, 2005 | 613 | 2005 |
| Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks MJ Kruhlak, A Celeste, G Dellaire, O Fernandez-Capetillo, WG Müller, ... The Journal of cell biology 172 (6), 823-834, 2006 | 606 | 2006 |
| A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations LI Toledo, M Murga, R Zur, R Soria, A Rodriguez, S Martinez, J Oyarzabal, ... Nature structural & molecular biology 18 (6), 721-727, 2011 | 523 | 2011 |
| Identification of early replicating fragile sites that contribute to genome instability JH Barlow, RB Faryabi, E Callén, N Wong, A Malhowski, HT Chen, ... Cell 152 (3), 620-632, 2013 | 471 | 2013 |
| Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice P Martínez, M Thanasoula, P Muñoz, C Liao, A Tejera, C McNees, ... Genes & development 23 (17), 2060-2075, 2009 | 429 | 2009 |
| A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging M Murga, S Bunting, MF Montana, R Soria, F Mulero, M Canamero, Y Lee, ... Nature genetics 41 (8), 891-898, 2009 | 416 | 2009 |
| Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors M Murga, S Campaner, AJ Lopez-Contreras, LI Toledo, R Soria, ... Nature structural & molecular biology 18 (12), 1331-1335, 2011 | 415 | 2011 |
| 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions E Callen, M Di Virgilio, MJ Kruhlak, M Nieto-Soler, N Wong, HT Chen, ... Cell 153 (6), 1266-1280, 2013 | 368 | 2013 |
| ATM regulates ATR chromatin loading in response to DNA double-strand breaks M Cuadrado, B Martinez-Pastor, M Murga, LI Toledo, P Gutierrez-Martinez, ... The Journal of experimental medicine 203 (2), 297-303, 2006 | 302 | 2006 |
| p38 Mitogen-Activated Protein Kinase- and HuR-Dependent Stabilization of p21Cip1 mRNA Mediates the G1/S Checkpoint V Lafarga, A Cuadrado, I Lopez de Silanes, R Bengoechea, ... Molecular and cellular biology 29 (16), 4341-4351, 2009 | 300 | 2009 |
