| Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell S Yui, T Nakamura, T Sato, Y Nemoto, T Mizutani, X Zheng, S Ichinose, ... Nature medicine 18 (4), 618-623, 2012 | 887 | 2012 |
| Mutational signature in colorectal cancer caused by genotoxic pks+E. coli C Pleguezuelos-Manzano, J Puschhof, A Rosendahl Huber, A van Hoeck, ... Nature 580 (7802), 269-273, 2020 | 786 | 2020 |
| Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer J Drost, R Van Boxtel, F Blokzijl, T Mizutani, N Sasaki, V Sasselli, J de Ligt, ... Science 358 (6360), 234-238, 2017 | 435 | 2017 |
| 5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation YH Cho, EJ Ro, JS Yoon, T Mizutani, DW Kang, JC Park, T Il Kim, ... Nature communications 11 (1), 5321, 2020 | 255 | 2020 |
| Co-culture with intestinal epithelial organoids allows efficient expansion and motility analysis of intraepithelial lymphocytes K Nozaki, W Mochizuki, Y Matsumoto, T Matsumoto, M Fukuda, T Mizutani, ... Journal of gastroenterology 51, 206-213, 2016 | 204 | 2016 |
| Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon M Fukuda, T Mizutani, W Mochizuki, T Matsumoto, K Nozaki, Y Sakamaki, ... Genes & development 28 (16), 1752-1757, 2014 | 172 | 2014 |
| Contribution of ATOH1+ cells to the homeostasis, repair, and tumorigenesis of the colonic epithelium F Ishibashi, H Shimizu, T Nakata, S Fujii, K Suzuki, A Kawamoto, S Anzai, ... Stem cell reports 10 (1), 27-42, 2018 | 60 | 2018 |
| Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells T Murano, R Okamoto, G Ito, T Nakata, S Hibiya, H Shimizu, S Fujii, ... Biochemical and biophysical research communications 443 (3), 840-846, 2014 | 54 | 2014 |
| Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro T Mizutani, T Nakamura, R Morikawa, M Fukuda, W Mochizuki, ... Biochemical and biophysical research communications 419 (2), 238-243, 2012 | 52 | 2012 |
| Lineage-specific expression of bestrophin-2 and bestrophin-4 in human intestinal epithelial cells G Ito, R Okamoto, T Murano, H Shimizu, S Fujii, T Nakata, T Mizutani, ... PloS one 8 (11), e79693, 2013 | 50 | 2013 |
| PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells S Fujii, K Suzuki, A Kawamoto, F Ishibashi, T Nakata, T Murano, G Ito, ... Scientific reports 6 (1), 36795, 2016 | 48 | 2016 |
| Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine H Shimizu, R Okamoto, G Ito, S Fujii, T Nakata, K Suzuki, T Murano, ... PeerJ 2, e370, 2014 | 42 | 2014 |
| Primary intestinal epithelial organoid culture T Mizutani, H Clevers Intestinal Stem Cells: Methods and Protocols, 185-200, 2020 | 34 | 2020 |
| Three-dimensional single-cell imaging for the analysis of RNA and protein expression in intact tumour biopsies N Tanaka, S Kanatani, D Kaczynska, K Fukumoto, L Louhivuori, ... Nature Biomedical Engineering 4 (9), 875-888, 2020 | 24 | 2020 |
| Intraepithelial lymphocytes suppress intestinal tumor growth by cell-to-cell contact via CD103/E-cadherin signal R Morikawa, Y Nemoto, Y Yonemoto, S Tanaka, Y Takei, S Oshima, ... Cellular and Molecular Gastroenterology and Hepatology 11 (5), 1483-1503, 2021 | 21 | 2021 |
| Notch and TNF-α signaling promote cytoplasmic accumulation of OLFM4 in intestinal epithelium cells and exhibit a cell protective role in the inflamed mucosa of IBD patients R Kuno, G Ito, A Kawamoto, Y Hiraguri, HY Sugihara, S Takeoka, ... Biochemistry and Biophysics Reports 25, 100906, 2021 | 17 | 2021 |
| KSR1-and ERK-dependent translational regulation of the epithelial-to-mesenchymal transition C Rao, DE Frodyma, S Southekal, RA Svoboda, AR Black, C Guda, ... Elife 10, e66608, 2021 | 16 | 2021 |
| MET signaling overcomes epidermal growth factor receptor inhibition in normal and colorectal cancer stem cells causing drug resistance SPJ Joosten, T Mizutani, M Spaargaren, H Clevers, ST Pals Gastroenterology 157 (4), 1153-1155. e1, 2019 | 16 | 2019 |
| Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors T Nakata, H Shimizu, S Nagata, G Ito, S Fujii, K Suzuki, A Kawamoto, ... Biochemical and biophysical research communications 482 (4), 1296-1303, 2017 | 14 | 2017 |
| Development and application of regenerative medicine in inflammatory bowel disease R Okamoto, T Mizutani, H Shimizu Digestion 104 (1), 24-29, 2023 | 12 | 2023 |
