Distinct roles for conformational dynamics in protein-ligand interactions X Liu, DC Speckhard, TR Shepherd, YJ Sun, SR Hengel, L Yu, CA Fowler, ... Structure 24 (12), 2053-2066, 2016 | 30 | 2016 |
Structure-based phylogeny identifies avoralstat as a TMPRSS2 inhibitor that prevents SARS-CoV-2 infection in mice YJ Sun, G Velez, DE Parsons, K Li, ME Ortiz, S Sharma, PB McCray, ... The Journal of Clinical Investigation 131 (10), 2021 | 26 | 2021 |
SGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility S Awadia, F Huq, TR Arnold, SM Goicoechea, YJ Sun, T Hou, ... Journal of Cell Biology 218 (8), 2699-2725, 2019 | 23 | 2019 |
Structural insights into the unique activation mechanisms of a non-classical calpain and its disease-causing variants G Velez, YJ Sun, S Khan, J Yang, J Herrmann, T Chemudupati, ... Cell reports 30 (3), 881-892. e5, 2020 | 20 | 2020 |
An intravitreal implant injection method for sustained drug delivery into mouse eyes YJ Sun, CH Lin, MR Wu, SH Lee, J Yang, CR Kunchur, EM Mujica, ... Cell reports methods 1 (8), 2021 | 16 | 2021 |
A simple PB/LIE free energy function accurately predicts the peptide binding specificity of the Tiam1 PDZ domain N Panel, YJ Sun, EJ Fuentes, T Simonson Frontiers in molecular biosciences 4, 65, 2017 | 16 | 2017 |
Liquid-biopsy proteomics combined with AI identifies cellular drivers of eye aging and disease in vivo J Wolf, DK Rasmussen, YJ Sun, JT Vu, E Wang, C Espinosa, F Bigini, ... Cell 186 (22), 4868-4884. e12, 2023 | 13 | 2023 |
Peptidomimetics Therapeutics for Retinal Disease DE Parsons, SH Lee, YJ Sun, G Velez, AG Bassuk, M Smith, VB Mahajan Biomolecules 11 (3), 339, 2021 | 11 | 2021 |
Calpains as mechanistic drivers and therapeutic targets for ocular disease JT Vu, E Wang, J Wu, YJ Sun, G Velez, AG Bassuk, SH Lee, VB Mahajan Trends in molecular medicine 28 (8), 644-661, 2022 | 8 | 2022 |
A physics-based energy function allows the computational redesign of a PDZ domain V Opuu, YJ Sun, T Hou, N Panel, EJ Fuentes, T Simonson Scientific Reports 10 (1), 11150, 2020 | 8 | 2020 |
Unleashing the potential of CRISPR multiplexing: Harnessing Cas12 and Cas13 for precise gene modulation in eye diseases F Bigini, SH Lee, YJ Sun, Y Sun, VB Mahajan Vision Research 213, 108317, 2023 | 5 | 2023 |
Novel mutations in the 3-box motif of the BACK domain of KLHL7 associated with nonsyndromic autosomal dominant retinitis pigmentosa JK Oh, JR Lima de Carvalho, YJ Sun, S Ragi, J Yang, SR Levi, J Ryu, ... Orphanet journal of rare diseases 14, 1-10, 2019 | 5 | 2019 |
Conjunctival Swabs Reveal Higher Detection Rate Compared to Schirmer Strips for SARS-CoV-2 RNA Detection in Tears of Hospitalized COVID-19 Patients LE Sabage, YJ Sun, J Wolf, J Sabage, A Mazzo, CF Santos, VB Mahajan, ... Journal of Clinical Medicine 11 (23), 6929, 2022 | 4 | 2022 |
Expanding the phenotype of TTLL5-associated retinal dystrophy: a case series JK Oh, JG Vargas Del Valle, JR Lima de Carvalho Jr, YJ Sun, SR Levi, ... Orphanet journal of rare diseases 17 (1), 146, 2022 | 4 | 2022 |
A protocol to inject ocular drug implants into mouse eyes CH Lin, YJ Sun, SH Lee, EM Mujica, CR Kunchur, MR Wu, J Yang, ... STAR protocols 3 (1), 101143, 2022 | 4 | 2022 |
New COL6A6 Variant Causes Autosomal Dominant Retinitis Pigmentosa in a Four-Generation Family V Vaclavik, L Tiab, YJ Sun, VB Mahajan, A Moulin, N Allaman-Pillet, ... Investigative Ophthalmology & Visual Science 63 (3), 23-23, 2022 | 3 | 2022 |
TMPRSS2 structure-phylogeny repositions Avoralstat for SARS-CoV-2 prophylaxis in mice Y Joo Sun, G Velez, D Parsons, K Li, M Ortiz, S Sharma, PB McCray Jr, ... bioRxiv, 2021.01. 04.425289, 2021 | 3 | 2021 |
Identification of highly potent and selective HTRA1 inhibitors DG Dennis, YJ Sun, DE Parsons, VB Mahajan, M Smith Bioorganic & Medicinal Chemistry Letters, 129814, 2024 | | 2024 |
Crystal Structure of The Human G267s Calpain-5 Protease Core Domain and Its Use in Rational Drug Design for Identifying Inhibitors of Calpain-5 V Mahajan, YJ Sun, G Velez, D Parsons US Patent App. 18/030,046, 2024 | | 2024 |
Macular dystrophy in Kabuki syndrome due to de novo KMT2D variants: refining the phenotype with multimodal imaging and follow-up over 10 years: insight into pathophysiology V Vaclavik, A Navarro, A Jacot-Guillarmod, A Bottani, YJ Sun, JA Franco, ... Graefe's Archive for Clinical and Experimental Ophthalmology, 1-8, 2024 | | 2024 |