The CamSol method of rational design of protein mutants with enhanced solubility P Sormanni, FA Aprile, M Vendruscolo Journal of molecular biology 427 (2), 478-490, 2015 | 415 | 2015 |
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, ... Proceedings of the National Academy of Sciences 114 (6), E1009-E1017, 2017 | 308 | 2017 |
MobiDB 3.0: more annotations for intrinsic disorder, conformational diversity and interactions in proteins D Piovesan, F Tabaro, L Paladin, M Necci, I Mičetić, C Camilloni, N Davey, ... Nucleic acids research 46 (D1), D471-D476, 2018 | 219 | 2018 |
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, ... Nature communications 10 (1), 1541, 2019 | 175 | 2019 |
Parapred: antibody paratope prediction using convolutional and recurrent neural networks E Liberis, P Veličković, P Sormanni, M Vendruscolo, P Liò Bioinformatics 34 (17), 2944-2950, 2018 | 146 | 2018 |
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TPJ Knowles, ... Science advances 3 (6), e1700488, 2017 | 146 | 2017 |
Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins P Sormanni, FA Aprile, M Vendruscolo Proceedings of the National Academy of Sciences 112 (32), 9902-9907, 2015 | 143 | 2015 |
Proteome-wide observation of the phenomenon of life on the edge of solubility G Vecchi, P Sormanni, B Mannini, A Vandelli, GG Tartaglia, CM Dobson, ... Proceedings of the National Academy of Sciences 117 (2), 1015-1020, 2020 | 124 | 2020 |
Rapid and accurate in silico solubility screening of a monoclonal antibody library P Sormanni, L Amery, S Ekizoglou, M Vendruscolo, B Popovic Scientific reports 7 (1), 8200, 2017 | 120 | 2017 |
Simultaneous quantification of protein order and disorder P Sormanni, D Piovesan, GT Heller, M Bonomi, P Kukic, C Camilloni, ... Nature chemical biology 13 (4), 339-342, 2017 | 120 | 2017 |
Third generation antibody discovery methods: in silico rational design P Sormanni, FA Aprile, M Vendruscolo Chemical Society Reviews 47 (24), 9137-9157, 2018 | 118 | 2018 |
A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer’s disease R Freer, P Sormanni, G Vecchi, P Ciryam, CM Dobson, M Vendruscolo Science advances 2 (8), e1600947, 2016 | 105 | 2016 |
The s2D method: simultaneous sequence-based prediction of the statistical populations of ordered and disordered regions in proteins P Sormanni, C Camilloni, P Fariselli, M Vendruscolo Journal of molecular biology 427 (4), 982-996, 2015 | 103 | 2015 |
Targeting disordered proteins with small molecules using entropy GT Heller, P Sormanni, M Vendruscolo Trends in biochemical sciences 40 (9), 491-496, 2015 | 101 | 2015 |
In vitro and in silico assessment of the developability of a designed monoclonal antibody library AM Wolf Pérez, P Sormanni, JS Andersen, LI Sakhnini, I Rodriguez-Leon, ... MAbs 11 (2), 388-400, 2019 | 78 | 2019 |
Rational design of a conformation-specific antibody for the quantification of Aβ oligomers FA Aprile, P Sormanni, M Podpolny, S Chhangur, LM Needham, ... Proceedings of the National Academy of Sciences 117 (24), 13509-13518, 2020 | 75 | 2020 |
Quantifying misfolded protein oligomers as drug targets and biomarkers in Alzheimer and Parkinson diseases K Kulenkampff, AM Wolf Perez, P Sormanni, J Habchi, M Vendruscolo Nature Reviews Chemistry 5 (4), 277-294, 2021 | 73 | 2021 |
A chemical kinetic basis for measuring translation initiation and elongation rates from ribosome profiling data AK Sharma, P Sormanni, N Ahmed, P Ciryam, UA Friedrich, G Kramer, ... PLoS computational biology 15 (5), e1007070, 2019 | 61 | 2019 |
Attentive cross-modal paratope prediction A Deac, P VeliČković, P Sormanni Journal of Computational Biology 26 (6), 536-545, 2019 | 60 | 2019 |
Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery M Perni, PK Challa, JB Kirkegaard, R Limbocker, M Koopman, ... Journal of neuroscience methods 306, 57-67, 2018 | 59 | 2018 |