Mechanism of MEK inhibition determines efficacy in mutant KRAS-versus BRAF-driven cancers G Hatzivassiliou, JR Haling, H Chen, K Song, S Price, R Heald, ... Nature 501 (7466), 232-237, 2013 | 332 | 2013 |
Mechanism of MEK inhibition determines efficacy in mutant KRAS-versus BRAF-driven cancers G Hatzivassiliou, JR Haling, H Chen, K Song, S Price, R Heald, ... Nature 501 (7466), 232-237, 2013 | 332 | 2013 |
Precarious balance: Th17 cells in host defense A Peck, ED Mellins Infection and immunity 78 (1), 32-38, 2010 | 297 | 2010 |
X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease S Günther, PYA Reinke, Y Fernández-García, J Lieske, TJ Lane, HM Ginn, ... Science, 2021 | 291 | 2021 |
Plasticity of T‐cell phenotype and function: the T helper type 17 example A Peck, ED Mellins Immunology 129 (2), 147-153, 2010 | 282 | 2010 |
Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signaling JR Haling, J Sudhamsu, I Yen, S Sideris, W Sandoval, W Phung, BJ Bravo, ... Cancer cell 26 (3), 402-413, 2014 | 228 | 2014 |
Breaking old paradigms: Th17 cells in autoimmune arthritis A Peck, ED Mellins Clinical Immunology 132 (3), 295-304, 2009 | 125 | 2009 |
Distribution of circulating cells in systemic juvenile idiopathic arthritis across disease activity states C Macaubas, K Nguyen, C Deshpande, C Phillips, A Peck, T Lee, JL Park, ... Clinical immunology 134 (2), 206-216, 2010 | 82 | 2010 |
Alternative activation in systemic juvenile idiopathic arthritis monocytes C Macaubas, KD Nguyen, A Peck, J Buckingham, C Deshpande, E Wong, ... Clinical Immunology 142 (3), 362-372, 2012 | 75 | 2012 |
Conformational heterogeneity of the calmodulin binding interface D Shukla, A Peck, VS Pande Nature communications 7, 2016 | 73 | 2016 |
Extensive site-directed mutagenesis reveals interconnected functional units in the alkaline phosphatase active site F Sunden, A Peck, J Salzman, S Ressl, D Herschlag Elife 4, e06181, 2015 | 67 | 2015 |
Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy JB Spangler, E Trotta, J Tomala, A Peck, TA Young, CS Savvides, ... The Journal of Immunology 201 (7), 2094-2106, 2018 | 66 | 2018 |
CryoAI: Amortized Inference of Poses for Ab Initio Reconstruction of 3D Molecular Volumes from Real Cryo-EM Images A Levy, F Poitevin, J Martel, Y Nashed, A Peck, N Miolane, D Ratner, ... arXiv preprint arXiv:2203.08138, 2022 | 35 | 2022 |
Tungstate as a transition state analog for catalysis by alkaline phosphatase A Peck, F Sunden, LD Andrews, VS Pande, D Herschlag Journal of molecular biology 428 (13), 2758-2768, 2016 | 35 | 2016 |
Montage electron tomography of vitrified specimens A Peck, SD Carter, H Mai, S Chen, A Burt, GJ Jensen | 29 | 2021 |
Intermolecular correlations are necessary to explain diffuse scattering from protein crystals A Peck, F Poitevin, TJ Lane arXiv preprint arXiv:1707.05433, 2017 | 25 | 2017 |
Inhibition of SARS-CoV-2 main protease by allosteric drug-binding S Guenther, PYA Reinke, Y Fernandez-Garcia, J Lieske, TJ Lane, H Ginn, ... bioRxiv, 2020 | 13 | 2020 |
Heterogeneous reconstruction of deformable atomic models in Cryo-EM Y Nashed, A Peck, J Martel, A Levy, B Koo, G Wetzstein, N Miolane, ... arXiv preprint arXiv:2209.15121, 2022 | 9 | 2022 |
Skopi: a simulation package for diffractive imaging of noncrystalline biomolecules A Peck, HY Chang, A Dujardin, D Ramalingam, M Uervirojnangkoorn, ... bioRxiv, 2021 | 9 | 2021 |
Catalytic cleavage of HEAT and subsequent covalent binding of the tetralone moiety by the SARS-CoV-2 main protease S Günther, PYA Reinke, D Oberthuer, O Yefanov, H Ginn, S Meier, ... bioRxiv, 2020 | 3 | 2020 |