A central role for dityrosine crosslinking of Amyloid-β in Alzheimer’s disease YK Al-Hilaly, TL Williams, M Stewart-Parker, L Ford, E Skaria, M Cole, ... Acta neuropathologica communications 1, 1-17, 2013 | 195 | 2013 |
Nuclear tau and its potential role in Alzheimer’s disease M Bukar Maina, YK Al-Hilaly, LC Serpell Biomolecules 6 (1), 9, 2016 | 173 | 2016 |
The involvement of dityrosine crosslinking in α-synuclein assembly and deposition in Lewy Bodies in Parkinson’s disease YK Al-Hilaly, L Biasetti, BJF Blakeman, SJ Pollack, S Zibaee, ... Scientific reports 6 (1), 39171, 2016 | 90 | 2016 |
Alzheimer's disease-like paired helical filament assembly from truncated tau protein is independent of disulfide crosslinking YK Al-Hilaly, SJ Pollack, DM Vadukul, F Citossi, JE Rickard, M Simpson, ... Journal of molecular biology 429 (23), 3650-3665, 2017 | 86 | 2017 |
A critical role for the self-assembly of Amyloid-β1-42 in neurodegeneration KE Marshall, DM Vadukul, L Dahal, A Theisen, MW Fowler, Y Al-Hilaly, ... Scientific reports 6 (1), 30182, 2016 | 83 | 2016 |
Tau (297‐391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer’s disease brain YK Al‐Hilaly, BE Foster, L Biasetti, L Lutter, SJ Pollack, JE Rickard, ... FEBS letters 594 (5), 944-950, 2020 | 72 | 2020 |
The elusive tau molecular structures: can we translate the recent breakthroughs into new targets for intervention? Y Fichou, YK Al-Hilaly, F Devred, C Smet-Nocca, PO Tsvetkov, J Verelst, ... Acta neuropathologica communications 7, 1-17, 2019 | 63 | 2019 |
Using chirality to influence supramolecular gelation K McAulay, B Dietrich, H Su, MT Scott, S Rogers, YK Al-Hilaly, H Cui, ... Chemical Science 10 (33), 7801-7806, 2019 | 51 | 2019 |
Tau filament self-assembly and structure: tau as a therapeutic target SS Oakley, MB Maina, KE Marshall, YK Al-Hilaly, CR Harrington, ... Frontiers in Neurology 11, 590754, 2020 | 41 | 2020 |
Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT) YK Al-Hilaly, SJ Pollack, JE Rickard, M Simpson, AC Raulin, T Baddeley, ... Journal of molecular biology 430 (21), 4119-4131, 2018 | 34 | 2018 |
The molecular basis for apolipoprotein E4 as the major risk factor for late-onset Alzheimer's disease AC Raulin, L Kraft, YK Al-Hilaly, WF Xue, JE McGeehan, JR Atack, ... Journal of molecular biology 431 (12), 2248-2265, 2019 | 33 | 2019 |
Structural identification of individual helical amyloid filaments by integration of cryo-electron microscopy-derived maps in comparative morphometric atomic force microscopy … L Lutter, YK Al-Hilaly, CJ Serpell, MF Tuite, CM Wischik, LC Serpell, ... Journal of Molecular Biology 434 (7), 167466, 2022 | 27 | 2022 |
The CDR1 and other regions of immunoglobulin light chains are hot spots for amyloid aggregation RA Ruiz-Zamora, S Guillaumé, YK Al-Hilaly, Z Al-Garawi, ... Scientific Reports 9 (1), 3123, 2019 | 19 | 2019 |
Metal-and UV-catalyzed oxidation results in trapped amyloid-β intermediates revealing that self-assembly is required for Aβ-induced cytotoxicity MB Maina, G Burra, YK Al-Hilaly, K Mengham, K Fennell, LC Serpell Iscience 23 (10), 2020 | 18 | 2020 |
Paired helical filament-forming region of tau (297–391) influences endogenous tau protein and accumulates in acidic compartments in human neuronal cells SJ Pollack, J Trigg, T Khanom, L Biasetti, KE Marshall, YK Al-Hilaly, ... Journal of molecular biology 432 (17), 4891-4907, 2020 | 16 | 2020 |
Methods for structural analysis of amyloid fibrils in misfolding diseases DM Vadukul, YK Al-Hilaly, LC Serpell Protein Misfolding Diseases: Methods and Protocols, 109-122, 2019 | 16 | 2019 |
Dityrosine cross-links are present in Alzheimer’s disease-derived tau oligomers and paired helical filaments (PHF) which promotes the stability of the PHF-core tau (297–391) in … MB Maina, YK Al-Hilaly, S Oakley, G Burra, T Khanom, L Biasetti, ... Journal of Molecular Biology 434 (19), 167785, 2022 | 11 | 2022 |
Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297–391) Intermediates MB Maina, YK Al-Hilaly, G Burra, JE Rickard, CR Harrington, CM Wischik, ... Cells 10 (3), 703, 2021 | 10 | 2021 |
Solid-state NMR of paired helical filaments formed by the core tau fragment tau (297-391) YK Al-Hilaly, C Hurt, JE Rickard, CR Harrington, JMD Storey, CM Wischik, ... Frontiers in Neuroscience 16, 988074, 2022 | 9 | 2022 |
The disease associated tau35 fragment has an increased propensity to aggregate compared to full-length tau C Lyu, S Da Vela, Y Al-Hilaly, KE Marshall, R Thorogate, D Svergun, ... Frontiers in Molecular Biosciences 8, 779240, 2021 | 7 | 2021 |