Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells M Norelli, B Camisa, G Barbiera, L Falcone, A Purevdorj, M Genua, ... Nature medicine 24 (6), 739-748, 2018 | 1226 | 2018 |
CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma M Casucci, B Nicolis di Robilant, L Falcone, B Camisa, M Norelli, ... Blood, The Journal of the American Society of Hematology 122 (20), 3461-3472, 2013 | 386 | 2013 |
CAR T cell manufacturing from naive/stem memory T lymphocytes enhances antitumor responses while curtailing cytokine release syndrome S Arcangeli, C Bove, C Mezzanotte, B Camisa, L Falcone, F Manfredi, ... The Journal of clinical investigation 132 (12), 2022 | 111 | 2022 |
Next-Generation Manufacturing Protocols Enriching TSCM CAR T Cells Can Overcome Disease-Specific T Cell Defects in Cancer Patients S Arcangeli, L Falcone, B Camisa, F De Girardi, M Biondi, F Giglio, ... Frontiers in immunology 11, 1217, 2020 | 100 | 2020 |
Extracellular NGFR spacers allow efficient tracking and enrichment of fully functional CAR-T cells co-expressing a suicide gene M Casucci, L Falcone, B Camisa, M Norelli, S Porcellini, A Stornaiuolo, ... Frontiers in immunology 9, 507, 2018 | 94 | 2018 |
Disrupting N-glycan expression on tumor cells boosts chimeric antigen receptor T cell efficacy against solid malignancies B Greco, V Malacarne, F De Girardi, GM Scotti, F Manfredi, E Angelino, ... Science translational medicine 14 (628), eabg3072, 2022 | 77 | 2022 |
Graft-versus-leukemia effect of HLA-haploidentical central-memory T-cells expanded with leukemic APCs and modified with a suicide gene M Casucci, SK Perna, L Falcone, B Camisa, Z Magnani, M Bernardi, ... Molecular Therapy 21 (2), 466-475, 2013 | 32 | 2013 |
CD4 CAR-T cells targeting CD19 play a key role in exacerbating cytokine release syndrome, while maintaining long-term responses C Bove, S Arcangeli, L Falcone, B Camisa, R El Khoury, B Greco, ... Journal for ImmunoTherapy of Cancer 11 (1), 2023 | 30 | 2023 |
Exploiting secreted luciferases to monitor tumor progression in vivo L Falcone, M Casucci Tumor Immunology: Methods and Protocols, 105-111, 2016 | 14 | 2016 |
Genetic engineering of T cells for the immunotherapy of haematological malignancies M Casucci, A Bondanza, L Falcone, E Provasi, Z Magnani, C Bonini Tissue antigens 79 (1), 4-14, 2012 | 11 | 2012 |
Co-expression of a suicide gene in CAR-redirected T cells enables the safe targeting of CD44v6 for leukemia and myeloma eradication M Casucci, BN di Robilant, L Falcone, B Camisa, P Genovese, B Gentner, ... Blood 120 (21), 949, 2012 | 10 | 2012 |
CD44v6 is required for in vivo tumorigenesis of human AML and MM cells: role of microenvironmental signals and therapeutic implications BN di Robilant, M Casucci, L Falcone, B Camisa, B Gentner, L Naldini, ... Blood 122 (21), 605, 2013 | 8 | 2013 |
Dual Transgenesis of T Cells with a Novel CD44v6-Specific Chimeric Antigen Receptor and a Suicide Gene for Safe and Effective Targeting of Chemoresistance in Hematopoietic Tumors M Casucci, L Falcone, BN di Robilant, B Camisa, P Genovese, B Gentner, ... Blood 118 (21), 3125, 2011 | 5 | 2011 |
myeloid leukemia and multiple myeloma CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma M Casucci, B Nicolis, L Falcone, B Camisa, M Norelli, P Genovese Blood 122, 3461-3472, 2013 | 4 | 2013 |
Combining De-Glycosylating Agents with CAR-T Cells for Targeting Solid Tumors and Reducing Toxicity B Greco, K Paolella, B Camisa, V Malacarne, L Falcone, A Graziani, ... Blood 132, 4544, 2018 | 2 | 2018 |
Monocyte-Derived IL-1 and IL-6 are Differentially Required for Cytokine Release Syndrome and Neurotoxicity by CAR-T Cells M Norelli, B Camisa, G Barbiera, L Falcone, A Purevdorj, M Genua, ... MOLECULAR THERAPY 26 (5), 10-11, 2018 | 2 | 2018 |
Off-tumor target expression levels do not predict CAR-T cell killing: a foundation for the safety of CD44v6-targeted T cells M Casucci, BN di Robilant, L Falcone, B Camisa, M Norelli, B Gentner, ... Blood 122 (21), 142, 2013 | 2 | 2013 |
Dual transgenesis of T cells with a CD44v6 CAR and a suicide gene for the safe eradication of myeloid leukemia and myeloma M Casucci, L Falcone, DRB Nicolis, B Camisa, P Genovese, B Gentner, ... Molecular Therapy 47, 2012 | 2 | 2012 |
Pre-selected CAR TN/SCM Outperform CAR T-BULK in Driving Tumor Eradication in the Absence of Cytokine Release Syndrome and Neurotoxicity C Mezzanotte, S Arcangeli, B Camisa, L Falcone, F Manfredi, R Norata, ... MOLECULAR THERAPY 28 (4), 42-42, 2020 | 1 | 2020 |
Monocytes are required for both optimal anti-leukemic efficacy and the cytokine release syndrome by CAR-T cells: lessons from an innovative xenotolerant mouse model M Norelli, M Casucci, B Camisa, L Falcone, C Traversari, C Bordignon, ... Blood 128 (22), 997, 2016 | 1 | 2016 |