Open-ended evolution: Perspectives from the OEE workshop in York T Taylor, M Bedau, A Channon, D Ackley, W Banzhaf, G Beslon, E Dolson, ... Artificial life 22 (3), 408-423, 2016 | 154 | 2016 |
At the biological modeling and simulation frontier CA Hunt, GEP Ropella, TN Lam, J Tang, SHJ Kim, JA Engelberg, ... Pharmaceutical research 26, 2369-2400, 2009 | 101 | 2009 |
Physiologically based synthetic models of hepatic disposition CA Hunt, GEP Ropella, L Yan, DY Hung, MS Roberts Journal of pharmacokinetics and pharmacodynamics 33, 737-772, 2006 | 78 | 2006 |
Essential operating principles for tumor spheroid growth JA Engelberg, GEP Ropella, CA Hunt BMC systems biology 2, 1-19, 2008 | 62 | 2008 |
Modeling and simulation of hepatic drug disposition using a physiologically based, multi-agent in silico liver L Yan, GEP Ropella, S Park, MS Roberts, CA Hunt Pharmaceutical research 25, 1023-1036, 2008 | 62 | 2008 |
Dichotomies between computational and mathematical models CA Hunt, GEP Ropella, S Park, J Engelberg Nature biotechnology 26 (7), 737-738, 2008 | 53 | 2008 |
Agent‐based modeling: a systematic assessment of use cases and requirements for enhancing pharmaceutical research and development productivity CA Hunt, RC Kennedy, SHJ Kim, GEP Ropella Wiley Interdisciplinary Reviews: Systems Biology and Medicine 5 (4), 461-480, 2013 | 50 | 2013 |
Software engineering considerations for individual‐based models GE Ropella, SF Railsback, SK Jackson Natural Resource Modeling 15 (1), 5-22, 2002 | 50 | 2002 |
Predictions of hepatic disposition properties using a mechanistically realistic, physiologically based model L Yan, S Sheihk-Bahaei, S Park, GEP Ropella, CA Hunt Drug metabolism and disposition 36 (4), 759-768, 2008 | 44 | 2008 |
Tracing multiscale mechanisms of drug disposition in normal and diseased livers S Park, SHJ Kim, GEP Ropella, MS Roberts, CA Hunt Journal of Pharmacology and Experimental Therapeutics 334 (1), 124-136, 2010 | 35 | 2010 |
Toward modular biological models: defining analog modules based on referent physiological mechanisms BK Petersen, GEP Ropella, CA Hunt BMC systems biology 8, 1-18, 2014 | 33 | 2014 |
Relational grounding facilitates development of scientifically useful multiscale models CA Hunt, GEP Ropella, T Lam, AD Gewitz Theoretical Biology and Medical Modelling 8, 1-23, 2011 | 33 | 2011 |
Competing mechanistic hypotheses of acetaminophen-induced hepatotoxicity challenged by virtual experiments AK Smith, BK Petersen, GEP Ropella, RC Kennedy, N Kaplowitz, ... PloS computational biology 12 (12), e1005253, 2016 | 29 | 2016 |
Computational strategies unravel and trace how liver disease changes hepatic drug disposition S Park, GEP Ropella, SHJ Kim, MS Roberts, CA Hunt Journal of Pharmacology and Experimental Therapeutics 328 (1), 294-305, 2009 | 28 | 2009 |
Using heuristic models to bridge the gap between analytic and experimental models in biology GE Ropella, CA Hunt, DA Nag Agent-Directed Simulation Symposium, Vol. Simulation Series 37 (2), 182-190, 2005 | 26 | 2005 |
Similarity measures for automated comparison of in silico and in vitro experimental results GEP Ropella, DA Nag, CA Hunt Proceedings of the 25th Annual International Conference of the IEEE …, 2003 | 21 | 2003 |
Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms AK Smith, GEP Ropella, MR McGill, P Krishnan, L Dutta, RC Kennedy, ... PLoS computational biology 16 (6), e1007622, 2020 | 20 | 2020 |
Cloud computing and validation of expandable in silico livers GEP Ropella, CA Hunt BMC systems biology 4, 1-13, 2010 | 19 | 2010 |
Methodological considerations of heuristic modeling of biological systems GEP Ropella, CA Hunt, S Sheikh-Bahaei Proceedings of the 9th world multi-conference on systemics, cybernetics and …, 2005 | 18 | 2005 |
Biomimetic in silico devices CA Hunt, GEP Ropella, MS Roberts, L Yan Computational Methods in Systems Biology: International Conference CMSB 2004 …, 2005 | 16 | 2005 |