Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression BP Fairfax, P Humburg, S Makino, V Naranbhai, D Wong, E Lau, L Jostins, ... Science 343 (6175), 1246949, 2014 | 858 | 2014 |
Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling IM Berenjeno, R Piñeiro, SD Castillo, W Pearce, N McGranahan, ... Nature communications 8 (1), 1773, 2017 | 72 | 2017 |
Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele H Al-Mossawi, N Yager, CA Taylor, E Lau, S Danielli, J de Wit, J Gilchrist, ... Nature Communications 10 (1), 4575, 2019 | 51 | 2019 |
Genomic mapping of the MHC transactivator CIITA using an integrated ChIP-seq and genetical genomics approach D Wong, W Lee, P Humburg, S Makino, E Lau, V Naranbhai, BP Fairfax, ... Genome biology 15, 1-15, 2014 | 45 | 2014 |
Genomic response to vitamin D supplementation in the setting of a randomized, placebo-controlled trial AJ Berlanga-Taylor, K Plant, A Dahl, E Lau, M Hill, D Sims, A Heger, ... EBioMedicine 31, 133-142, 2018 | 36 | 2018 |
Natural Killer cells demonstrate distinct eQTL and transcriptome-wide disease associations, highlighting their role in autoimmunity JJ Gilchrist, S Makino, V Naranbhai, PK Sharma, S Koturan, O Tong, ... Nature Communications 13 (1), 4073, 2022 | 20 | 2022 |
Fine-scale genetic structure in the United Arab Emirates reflects endogamous and consanguineous culture, population history, and geography KS Elliott, M Haber, H Daggag, GB Busby, R Sarwar, D Kennet, ... Molecular biology and evolution 39 (3), msac039, 2022 | 14 | 2022 |
Perspective: potential impact and therapeutic implications of oncogenic PI3K activation on chromosomal instability B Vanhaesebroeck, B Bilanges, RR Madsen, KL Dale, E Lau, ... Biomolecules 9 (8), 331, 2019 | 12 | 2019 |
The autoimmune disease risk allele rs6897932 modulates monocyte IL7R surface and soluble receptor levels in a context-specific manner H Al-Mossawi, E Lau, S Danielli, N Yager, J de Wit, S Makino, J Gilchrist, ... BiorXiv, 262410, 2018 | 4 | 2018 |
Context-specific regulation of monocyte surface IL7R expression and soluble receptor secretion by a common autoimmune risk allele H Al-Mossawi, N Yager, C Taylor, E Lau, S Danielli, J de Wit, J Gilchrist, ... | 3 | 2018 |
Effect of vitamin D supplementation on biomarkers of inflammation and immune function: functional genomics analysis of the BEST-D trial AJ Berlanga-Taylor, K Plant, A Dahl, E Lau, M Hill, D Sims, A Heger, ... bioRxiv, 217612, 2017 | 2 | 2017 |
Multi-output prediction of dose–response curves enables drug repositioning and biomarker discovery JJG Gutierrez, E Lau, S Dharmapalan, M Parker, Y Chen, MA Álvarez, ... npj Precision Oncology 8 (1), 209, 2024 | | 2024 |
Genetic determinants of monocyte splicing are enriched for disease susceptibility loci including for COVID-19 B Fairfax, I Nassiri, J Gilchrist, O Tong, E Lau, S Danielli, H Al-Mossawi, ... | | 2024 |
Characterization of the genetic determinants of context-specific DNA methylation in primary monocytes JJ Gilchrist, H Fang, S Danielli, M Tomkova, I Nassiri, E Ng, O Tong, ... Cell Genomics 4 (5), 2024 | | 2024 |
Multi-output prediction of dose-response curves enable drug repositioning and biomarker discovery D Wang, JJG Gutierrez, E Lau, S Dharmapalan, M Parker, Y Chen, ... | | 2023 |
Genomic and epigenomic impact of oncogenic mutation in the PIK3CA gene EKW Lau UCL (University College London), 2021 | | 2021 |
GENETIC DETERMINANTS OF TRANSCRIPTIONAL VARIATION IN PRIMARY HUMAN MONOCYTES ACROSS MULTIPLE CONTEXTS I Nassiri, S Danielli, E Lau, J Gilchrist, H Al-Mossawi, E Mahe, JC Knight, ... EUROPEAN JOURNAL OF HUMAN GENETICS 27, 1713-1714, 2019 | | 2019 |
OP0286 Genotypic effects of ankylosing spondylitis associated il7r polymorphisms are mediated through monocytes in inflammation MH Al-Mossawi, E Lau, S Danielli, N Yager, J De Wit, E Mahe, L Rizvi, ... Annals of the Rheumatic Diseases 77 (Suppl 2), 191-191, 2018 | | 2018 |