| Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein DJ Clancy, D Gems, LG Harshman, S Oldham, H Stocker, E Hafen, ... Science 292 (5514), 104-106, 2001 | 1751 | 2001 |
| Ribosomal protein S6 kinase 1 signaling regulates mammalian life span C Selman, JMA Tullet, D Wieser, E Irvine, SJ Lingard, AI Choudhury, ... Science 326 (5949), 140-144, 2009 | 1253 | 2009 |
| Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism F Cabreiro, C Au, KY Leung, N Vergara-Irigaray, HM Cochemé, T Noori, ... Cell 153 (1), 228-239, 2013 | 994 | 2013 |
| Unraveling the biological roles of reactive oxygen species MP Murphy, A Holmgren, NG Larsson, B Halliwell, CJ Chang, ... Cell metabolism 13 (4), 361-366, 2011 | 885 | 2011 |
| Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans D Gems, AJ Sutton, ML Sundermeyer, PS Albert, KV King, ML Edgley, ... Genetics 150 (1), 129-155, 1998 | 857 | 1998 |
| Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila C Burnett, S Valentini, F Cabreiro, M Goss, M Somogyvári, MD Piper, ... nature 477 (7365), 482-485, 2011 | 756 | 2011 |
| Genetics of longevity in model organisms: debates and paradigm shifts D Gems, L Partridge Annual review of physiology 75 (1), 621-644, 2013 | 625 | 2013 |
| Interventions to slow aging in humans: are we ready? VD Longo, A Antebi, A Bartke, N Barzilai, HM Brown‐Borg, C Caruso, ... Aging cell 14 (4), 497-510, 2015 | 618 | 2015 |
| Mechanisms of aging: public or private? L Partridge, D Gems Nature Reviews Genetics 3 (3), 165-175, 2002 | 618 | 2002 |
| Evidence for lifespan extension and delayed age–related biomarkers in insulin receptor substrate 1 null mice C Selman, S Lingard, AI Choudhury, RL Batterham, M Claret, M Clements, ... The FASEB Journal 22 (3), 807-818, 2008 | 612 | 2008 |
| Stress-response hormesis and aging:“that which does not kill us makes us stronger” D Gems, L Partridge Cell metabolism 7 (3), 200-203, 2008 | 598 | 2008 |
| Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans TM Bass, D Weinkove, K Houthoofd, D Gems, L Partridge Mechanisms of ageing and development 128 (10), 546-552, 2007 | 594 | 2007 |
| Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans R Doonan, JJ McElwee, F Matthijssens, GA Walker, K Houthoofd, P Back, ... Genes & development 22 (23), 3236-3241, 2008 | 564 | 2008 |
| Sex and death: what is the connection? L Partridge, D Gems, DJ Withers Cell 120 (4), 461-472, 2005 | 530 | 2005 |
| Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo MP Murphy, H Bayir, V Belousov, CJ Chang, KJA Davies, MJ Davies, ... Nature metabolism 4 (6), 651-662, 2022 | 519 | 2022 |
| Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance JJ McElwee, E Schuster, E Blanc, JH Thomas, D Gems Journal of Biological Chemistry 279 (43), 44533-44543, 2004 | 465 | 2004 |
| Dietary restriction in long-lived dwarf flies DJ Clancy, D Gems, E Hafen, SJ Leevers, L Partridge Science 296 (5566), 319-319, 2002 | 348 | 2002 |
| Antioxidant defense and aging in C. elegans: Is the oxidative damage theory of aging wrong? D Gems, R Doonan Cell cycle 8 (11), 1681-1687, 2009 | 334 | 2009 |
| Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix HM Cochemé, C Quin, SJ McQuaker, F Cabreiro, A Logan, TA Prime, ... Cell metabolism 13 (3), 340-350, 2011 | 325 | 2011 |
| Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans D Gems, DL Riddle Genetics 154 (4), 1597-1610, 2000 | 322 | 2000 |
