| A structural basis for drug-induced long QT syndrome JS Mitcheson, J Chen, M Lin, C Culberson, MC Sanguinetti Proceedings of the National Academy of Sciences 97 (22), 12329-12333, 2000 | 1146 | 2000 |
| Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation J Chen, SK Joshi, S DiDomenico, RJ Perner, JP Mikusa, DM Gauvin, ... Pain 152 (5), 1165-1172, 2011 | 319 | 2011 |
| Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate JS Mitcheson, J Chen, MC Sanguinetti The Journal of general physiology 115 (3), 229-240, 2000 | 302 | 2000 |
| Species differences and molecular determinant of TRPA1 cold sensitivity J Chen, D Kang, J Xu, M Lake, JO Hogan, C Sun, K Walter, B Yao, D Kim Nature communications 4 (1), 2501, 2013 | 292 | 2013 |
| Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation J Chen, A Zou, I Splawski, MT Keating, MC Sanguinetti Journal of Biological Chemistry 274 (15), 10113-10118, 1999 | 282 | 1999 |
| ALARM NMR: a rapid and robust experimental method to detect reactive false positives in biochemical screens JR Huth, R Mendoza, ET Olejniczak, RW Johnson, DA Cothron, Y Liu, ... Journal of the American Chemical Society 127 (1), 217-224, 2005 | 251 | 2005 |
| Position of aromatic residues in the S6 domain, not inactivation, dictates cisapride sensitivity of HERG and eag potassium channels J Chen, G Seebohm, MC Sanguinetti Proceedings of the National Academy of Sciences 99 (19), 12461-12466, 2002 | 227 | 2002 |
| Structural basis of Nav1. 7 inhibition by a gating-modifier spider toxin H Xu, T Li, A Rohou, CP Arthur, F Tzakoniati, E Wong, A Estevez, C Kugel, ... Cell 176 (4), 702-715. e14, 2019 | 222 | 2019 |
| Molecular determinants of voltage-dependent human ether-a-go-go related gene (HERG) K+ channel block JA Sánchez-Chapula, RA Navarro-Polanco, C Culberson, J Chen, ... Journal of Biological Chemistry 277 (26), 23587-23595, 2002 | 207 | 2002 |
| Interactions between S4-S5 linker and S6 transmembrane domain modulate gating of HERG K+ channels M Tristani-Firouzi, J Chen, MC Sanguinetti Journal of Biological Chemistry 277 (21), 18994-19000, 2002 | 194 | 2002 |
| TRPA1 as a drug target—promise and challenges J Chen, DH Hackos Naunyn-Schmiedeberg's archives of pharmacology 388, 451-463, 2015 | 191 | 2015 |
| Molecular biology of K+ channels and their role in cardiac arrhythmias M Tristani-Firouzi, J Chen, JS Mitcheson, MC Sanguinetti The American journal of medicine 110 (1), 50-59, 2001 | 191 | 2001 |
| The S4–S5 linker couples voltage sensing and activation of pacemaker channels J Chen, JS Mitcheson, M Tristani-Firouzi, M Lin, MC Sanguinetti Proceedings of the National Academy of Sciences 98 (20), 11277-11282, 2001 | 185 | 2001 |
| Voltage-dependent gating of hyperpolarization-activated, cyclic nucleotide-gated pacemaker channels: molecular coupling between the S4–S5 and C-linkers N Decher, J Chen, MC Sanguinetti Journal of Biological Chemistry 279 (14), 13859-13865, 2004 | 148 | 2004 |
| Pore dilation occurs in TRPA1 but not in TRPM8 channels J Chen, D Kim, BR Bianchi, EJ Cavanaugh, CR Faltynek, PR Kym, ... Molecular pain 5, 1744-8069-5-3, 2009 | 142 | 2009 |
| Transient receptor potential A1 mediates an osmotically activated ion channel XF Zhang, J Chen, CR Faltynek, RB Moreland, TR Neelands European Journal of Neuroscience 27 (3), 605-611, 2008 | 128 | 2008 |
| Molecular determinants of species-specific activation or blockade of TRPA1 channels J Chen, XF Zhang, ME Kort, JR Huth, C Sun, LJ Miesbauer, SC Cassar, ... Journal of Neuroscience 28 (19), 5063-5071, 2008 | 127 | 2008 |
| Functional roles of charged residues in the putative voltage sensor of the HCN2 pacemaker channel J Chen, JS Mitcheson, M Lin, MC Sanguinetti Journal of Biological Chemistry 275 (46), 36465-36471, 2000 | 117 | 2000 |
| Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels G Seebohm, M Pusch, J Chen, MC Sanguinetti Circulation research 93 (10), 941-947, 2003 | 107 | 2003 |
| Molecular determinants of KCNQ1 channel block by a benzodiazepine G Seebohm, J Chen, N Strutz, C Culberson, C Lerche, MC Sanguinetti Molecular pharmacology 64 (1), 70-77, 2003 | 105 | 2003 |
