| Pivotal role of the glycine-rich TM3 helix in gating the MscS mechanosensitive channel MD Edwards, Y Li, S Kim, S Miller, W Bartlett, S Black, S Dennison, I Iscla, ... Nature structural & molecular biology 12 (2), 113-119, 2005 | 148 | 2005 |
| Sensing and responding to membrane tension: the bacterial MscL channel as a model system I Iscla, P Blount Biophysical journal 103 (2), 169-174, 2012 | 90 | 2012 |
| On the structure of the N-terminal domain of the MscL channel: helical bundle or membrane interface I Iscla, R Wray, P Blount Biophysical journal 95 (5), 2283-2291, 2008 | 84 | 2008 |
| Streptomycin potency is dependent on MscL channel expression I Iscla, R Wray, S Wei, B Posner, P Blount Nature communications 5 (1), 4891, 2014 | 72 | 2014 |
| Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance X Zhang, J Wang, Y Feng, J Ge, W Li, W Sun, I Iscla, J Yu, P Blount, Y Li, ... Proceedings of the National Academy of Sciences 109 (44), 18180-18185, 2012 | 70 | 2012 |
| Defining the physical gate of a mechanosensitive channel, MscL, by engineering metal-binding sites I Iscla, G Levin, R Wray, R Reynolds, P Blount Biophysical journal 87 (5), 3172-3180, 2004 | 61 | 2004 |
| A new antibiotic with potent activity targets MscL I Iscla, R Wray, P Blount, J Larkins-Ford, AL Conery, FM Ausubel, S Ramu, ... The Journal of antibiotics 68 (7), 453-462, 2015 | 59 | 2015 |
| Life with bacterial mechanosensitive channels, from discovery to physiology to pharmacological target P Blount, I Iscla Microbiology and Molecular Biology Reviews 84 (1), 10.1128/mmbr. 00055-19, 2020 | 56 | 2020 |
| Dihydrostreptomycin directly binds to, modulates, and passes through the MscL channel pore R Wray, I Iscla, Y Gao, H Li, J Wang, P Blount PLoS biology 14 (6), e1002473, 2016 | 47 | 2016 |
| Improving the design of a MscL-based triggered nanovalve I Iscla, C Eaton, J Parker, R Wray, Z Kovács, P Blount Biosensors 3 (1), 171-184, 2013 | 41 | 2013 |
| The oligomeric state of the truncated mechanosensitive channel of large conductance shows no variance in vivo I Iscla, R Wray, P Blount Protein Science 20 (9), 1638-1642, 2011 | 37 | 2011 |
| Disulfide trapping the mechanosensitive channel MscL into a gating-transition state I Iscla, G Levin, R Wray, P Blount Biophysical journal 92 (4), 1224-1232, 2007 | 35 | 2007 |
| Scanning MscL channels with targeted post-translational modifications for functional alterations I Iscla, R Wray, C Eaton, P Blount PloS one 10 (9), e0137994, 2015 | 29 | 2015 |
| MscL: the bacterial mechanosensitive channel of large conductance P Blount, I Iscla, PC Moe, Y Li Current topics in membranes 58, 201-233, 2007 | 28 | 2007 |
| An in vivo screen reveals protein-lipid interactions crucial for gating a mechanosensitive channel I Iscla, R Wray, P Blount The FASEB Journal 25 (2), 694, 2011 | 27 | 2011 |
| Mechanosensitive channels gated by membrane tension: bacteria and beyond P Blount, L Yuezhou, PC Moe, I Iscla mechanosensitive ion channels, 71-101, 2008 | 24 | 2008 |
| Novel MscL agonists that allow multiple antibiotics cytoplasmic access activate the channel through a common binding site R Wray, J Wang, I Iscla, P Blount PLoS One 15 (1), e0228153, 2020 | 21 | 2020 |
| Novel compounds that specifically bind and modulate MscL: insights into channel gating mechanisms R Wray, I Iscla, Z Kovacs, J Wang, P Blount The FASEB Journal 33 (3), 3180, 2019 | 21 | 2019 |
| An agonist of the MscL channel affects multiple bacterial species and increases membrane permeability and potency of common antibiotics R Wray, N Herrera, I Iscla, J Wang, P Blount Molecular microbiology 112 (3), 896-905, 2019 | 19 | 2019 |
| Selective serotonin reuptake inhibitors induce spontaneous interneuronal activity in the leech nervous system MA Calviño, IR Iscla, L Szczupak Journal of neurophysiology 93 (5), 2644-2655, 2005 | 16 | 2005 |
