| Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes M Altun, HB Kramer, LI Willems, JL McDermott, CA Leach, SJ Goldenberg, ... Chemistry & biology 18 (11), 1401-1412, 2011 | 412 | 2011 |
| Novel activity-based probes for broad-spectrum profiling of retaining β-exoglucosidases in situ and in vivo WW Kallemeijn, KY Li, MD Witte, ARA Marques, J Aten, S Scheij, J Jiang, ... Angewandte Chemie International Edition 51 (50), 12529-12533, 2012 | 168 | 2012 |
| Current developments in activity-based protein profiling LI Willems, HS Overkleeft, SI Van Kasteren Bioconjugate chemistry 25 (7), 1181-1191, 2014 | 159 | 2014 |
| Triple bioorthogonal ligation strategy for simultaneous labeling of multiple enzymatic activities LI Willems, N Li, BI Florea, M Ruben, GA Van Der Marel, HS Overkleeft Angewandte Chemie 124 (18), 4507-4510, 2012 | 142 | 2012 |
| Gaucher disease and Fabry disease: new markers and insights in pathophysiology for two distinct glycosphingolipidoses MJ Ferraz, WW Kallemeijn, M Mirzaian, DH Moro, A Marques, P Wisse, ... Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2014 | 136 | 2014 |
| Bioorthogonal chemistry: applications in activity-based protein profiling LI Willems, WA Van der Linden, N Li, KY Li, N Liu, S Hoogendoorn, ... Accounts of chemical research 44 (9), 718-729, 2011 | 130 | 2011 |
| Structural and functional insight into human O-GlcNAcase C Roth, S Chan, WA Offen, GR Hemsworth, LI Willems, DT King, ... Nature chemical biology 13 (6), 610-612, 2017 | 116 | 2017 |
| Relative quantification of proteasome activity by activity-based protein profiling and LC-MS/MS N Li, CL Kuo, G Paniagua, H Van Den Elst, M Verdoes, LI Willems, ... Nature protocols 8 (6), 1155-1168, 2013 | 112 | 2013 |
| Synthesis of pH-activatable red fluorescent BODIPY dyes with distinct functionalities S Hoogendoorn, AEM Blom, LI Willems, GA Van Der Marel, HS Overkleeft Organic letters 13 (20), 5656-5659, 2011 | 84 | 2011 |
| Small molecule antagonists for chemokine CCR3 receptors LI Willems, AP IJzerman Medicinal research reviews 30 (5), 778-817, 2010 | 82 | 2010 |
| Acylazetine as a dienophile in bioorthogonal inverse electron-demand Diels–Alder ligation SB Engelsma, LI Willems, CE Van Paaschen, SI Van Kasteren, ... Organic letters 16 (10), 2744-2747, 2014 | 77 | 2014 |
| Regulation of immunoproteasome function in the lung IE Keller, O Vosyka, S Takenaka, A Kloß, B Dahlmann, LI Willems, ... Scientific reports 5 (1), 10230, 2015 | 74 | 2015 |
| A panel of subunit-selective activity-based proteasome probes M Verdoes, LI Willems, WA Van Der Linden, BA Duivenvoorden, ... Organic & biomolecular chemistry 8 (12), 2719-2727, 2010 | 73 | 2010 |
| Proteasome activity imaging and profiling characterizes bacterial effector syringolin A I Kolodziejek, JC Misas-Villamil, F Kaschani, J Clerc, C Gu, D Krahn, ... Plant physiology 155 (1), 477-489, 2011 | 71 | 2011 |
| From covalent glycosidase inhibitors to activity‐based glycosidase probes LI Willems, J Jiang, KY Li, MD Witte, WW Kallemeijn, TJN Beenakker, ... Chemistry–A European Journal 20 (35), 10864-10872, 2014 | 70 | 2014 |
| Potent and selective activity-based probes for GH27 human retaining α-galactosidases LI Willems, TJM Beenakker, B Murray, S Scheij, WW Kallemeijn, RG Boot, ... Journal of the American Chemical Society 136 (33), 11622-11625, 2014 | 69 | 2014 |
| Azido-BODIPY acid reveals quantitative Staudinger–Bertozzi ligation in two-step activity-based proteasome profiling M Verdoes, BI Florea, U Hillaert, LI Willems, WA Van Der Linden, ... Chembiochem: a European journal of chemical biology 9 (11), 1735, 2008 | 66 | 2008 |
| Two‐step labeling of endogenous enzymatic activities by Diels–Alder ligation LI Willems, M Verdoes, BI Florea, GA Van Der Marel, HS Overkleeft ChemBioChem 11 (12), 1769-1781, 2010 | 63 | 2010 |
| Direct One-Step Fluorescent Labeling of O-GlcNAc-Modified Proteins in Live Cells Using Metabolic Intermediates HY Tan, R Eskandari, D Shen, Y Zhu, TW Liu, LI Willems, MG Alteen, ... Journal of the American Chemical Society 140 (45), 15300-15308, 2018 | 49 | 2018 |
| Discovery of a potent and highly β 1 specific proteasome inhibitor from a focused library of urea-containing peptide vinyl sulfones and peptide epoxyketones WA Van Der Linden, LI Willems, TB Shabaneh, N Li, M Ruben, BI Florea, ... Organic & biomolecular chemistry 10 (1), 181-194, 2012 | 36 | 2012 |
