| The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells P Muñoz-Guardiola, J Casas, E Megías-Roda, S Solé, H Perez-Montoyo, ... Autophagy 17 (6), 1349-1366, 2021 | 89 | 2021 |
| The new antitumor drug ABTL0812 inhibits the Akt/mTORC1 axis by upregulating tribbles-3 pseudokinase T Erazo, M Lorente, A López-Plana, P Muñoz-Guardiola, ... Clinical Cancer Research 22 (10), 2508-2519, 2016 | 75 | 2016 |
| ERK5 and cell proliferation: nuclear localization is what matters N Gomez, T Erazo, JM Lizcano Frontiers in cell and developmental biology 4, 105, 2016 | 72 | 2016 |
| Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 … T Erazo, A Moreno, G Ruiz-Babot, A Rodríguez-Asiain, NA Morrice, ... Molecular and cellular biology, 2013 | 68 | 2013 |
| Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo [e] pyrimido-[5, 4-b] diazepine-6 (11H)-ones X Deng, JM Elkins, J Zhang, Q Yang, T Erazo, N Gomez, HG Choi, ... European journal of medicinal chemistry 70, 758-767, 2013 | 61 | 2013 |
| Structural and atropisomeric factors governing the selectivity of pyrimido-benzodiazipinones as inhibitors of kinases and bromodomains J Wang, T Erazo, FM Ferguson, DL Buckley, N Gomez, ... ACS chemical biology 13 (9), 2438-2448, 2018 | 59 | 2018 |
| NOXA genetic amplification or pharmacologic induction primes lymphoma cells to BCL2 inhibitor-induced cell death Y Liu, P Mondello, T Erazo, NB Tannan, Z Asgari, E de Stanchina, ... Proceedings of the National Academy of Sciences 115 (47), 12034-12039, 2018 | 51 | 2018 |
| X-ray crystal structure of ERK5 (MAPK7) in complex with a specific inhibitor JM Elkins, J Wang, X Deng, MJ Pattison, JSC Arthur, T Erazo, N Gomez, ... Journal of medicinal chemistry 56 (11), 4413-4421, 2013 | 42 | 2013 |
| BET inhibition-induced GSK3β feedback enhances lymphoma vulnerability to PI3K inhibitors E Derenzini, P Mondello, T Erazo, A Portelinha, Y Liu, M Scallion, ... Cell reports 24 (8), 2155-2166, 2018 | 37 | 2018 |
| SUMOylation is required for ERK5 nuclear translocation and ERK5-mediated cancer cell proliferation T Erazo, S Espinosa-Gil, N Diéguez-Martínez, N Gómez, JM Lizcano International Journal of molecular sciences 21 (6), 2203, 2020 | 33 | 2020 |
| Brain specific kinase-1 BRSK1/SAD-B associates with lipid rafts: modulation of kinase activity by lipid environment A Rodríguez-Asiain, G Ruiz-Babot, W Romero, R Cubí, T Erazo, ... Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2011 | 28 | 2011 |
| Oncosuppressive functions of tribbles pseudokinase 3. M Salazar, M Lorente, A Orea-Soufi, D Dávila, T Erazo, J Lizcano, ... Biochemical Society Transactions 43 (5), 2015 | 24 | 2015 |
| PDR-1/hParkin negatively regulates the phagocytosis of apoptotic cell corpses in Caenorhabditis elegans J Cabello, J Sämann, E Gómez-Orte, T Erazo, A Coppa, A Pujol, I Büssing, ... Cell Death & Disease 5 (3), e1120-e1120, 2014 | 19 | 2014 |
| The novel proautophagy anticancer drug ABTL0812 potentiates chemotherapy in adenocarcinoma and squamous nonsmall cell lung cancer A López‐Plana, P Fernández‐Nogueira, P Muñoz‐Guardiola, ... International Journal of Cancer 147 (4), 1163-1179, 2020 | 18 | 2020 |
| TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma T Erazo, CM Evans, D Zakheim, EL Chu, AY Refermat, Z Asgari, X Yang, ... Nature Communications 13 (1), 5676, 2022 | 10 | 2022 |
| The antitumour drug ABTL0812 impairs neuroblastoma growth through endoplasmic reticulum stress-mediated autophagy and apoptosis L París-Coderch, A Soriano, C Jiménez, T Erazo, P Muñoz-Guardiola, ... Cell Death & Disease 11 (9), 773, 2020 | 10 | 2020 |
| Synthetic lethality of drug-induced polyploidy and BCL-2 inhibition in lymphoma A Portelinha, M da Silva Ferreira, T Erazo, M Jiang, Z Asgari, ... Nature Communications 14 (1), 1522, 2023 | 7 | 2023 |
| Determination of recommended phase II dose of ABTL0812, a novel regulator of Akt/mTOR axis, by pharmacokinetic-pharmacodynamic modelling J Alfon, L Vidal, L Gaba, I Victoria, M Gil, B Laquente, M Brunet, H Colom, ... Annals of Oncology 27, vi120, 2016 | 3 | 2016 |
| Pharmacologically induced polyploidy triggers BCL2 dependence in lymphomas A Portelinha, MS Ferreira, T Erazo, Z Asgari, E de Stanchina, A Younes, ... Cancer Research 82 (12_Supplement), 359-359, 2022 | | 2022 |
| The anticancer drug ABTL0812 induces cancer cell death by impairing Akt/mTORC1 axis and inducing ER stress-mediated cytotoxic autophagy P Muñoz-Guardiola, J Casas, E Megías-Roda, H Perez-Montoyo, ... Cancer Research 80 (16_Supplement), 1234-1234, 2020 | | 2020 |
