| 5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase. PA Lochhead, IP Salt, KS Walker, DG Hardie, C Sutherland Diabetes 49 (6), 896-903, 2000 | 524 | 2000 |
| Activation-loop autophosphorylation is mediated by a novel transitional intermediate form of DYRKs PA Lochhead, G Sibbet, N Morrice, V Cleghon Cell 121 (6), 925-936, 2005 | 340 | 2005 |
| A chaperone-dependent GSK3β transitional intermediate mediates activation-loop autophosphorylation PA Lochhead, R Kinstrie, G Sibbet, T Rawjee, N Morrice, V Cleghon Molecular cell 24 (4), 627-633, 2006 | 318 | 2006 |
| Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphoenolpyruvate carboxykinase gene expression PA Lochhead, M Coghlan, SQJ Rice, C Sutherland Diabetes 50 (5), 937-946, 2001 | 306 | 2001 |
| Activating ROCK1 somatic mutations in human cancer PA Lochhead, G Wickman, M Mezna, MF Olson Oncogene 29 (17), 2591-2598, 2010 | 114 | 2010 |
| ERK5 and its role in tumour development PA Lochhead, R Gilley, SJ Cook Biochemical Society Transactions 40 (1), 251-256, 2012 | 109 | 2012 |
| Protein kinase activation loop autophosphorylation in cis: overcoming a Catch-22 situation PA Lochhead Science signaling 2 (54), pe4-pe4, 2009 | 78 | 2009 |
| DYRK1A-mediated cyclin D1 degradation in neural stem cells contributes to the neurogenic cortical defects in down syndrome S Najas, J Arranz, PA Lochhead, AL Ashford, D Oxley, JM Delabar, ... EBioMedicine 2 (2), 120-134, 2015 | 76 | 2015 |
| A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr286, not Thr288 AL Ashford, D Oxley, J Kettle, K Hudson, S Guichard, SJ Cook, ... Biochemical Journal 457 (1), 43-56, 2014 | 71 | 2014 |
| dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila PA Lochhead, G Sibbet, R Kinstrie, T Cleghon, M Rylatt, DK Morrison, ... Biochemical Journal 374 (2), 381-391, 2003 | 61 | 2003 |
| Characterization of a domain that transiently converts class 2 DYRKs into intramolecular tyrosine kinases R Kinstrie, N Luebbering, D Miranda-Saavedra, G Sibbet, J Han, ... Science signaling 3 (111), ra16-ra16, 2010 | 54 | 2010 |
| Insulin regulation of insulin-like growth factor-binding protein-1 gene expression is dependent on the mammalian target of rapamycin, but independent of ribosomal S6 kinase … S Patel, PA Lochhead, G Rena, S Fumagalli, M Pende, SC Kozma, ... Journal of Biological Chemistry 277 (12), 9889-9895, 2002 | 47 | 2002 |
| Paradoxical activation of the protein kinase-transcription factor ERK5 by ERK5 kinase inhibitors PA Lochhead, JA Tucker, NJ Tatum, J Wang, D Oxley, AM Kidger, ... Nature communications 11 (1), 1383, 2020 | 43 | 2020 |
| Tumor cells with KRAS or BRAF mutations or ERK5/MAPK7 amplification are not addicted to ERK5 activity for cell proliferation PA Lochhead, J Clark, LZ Wang, L Gilmour, M Squires, R Gilley, C Foxton, ... Cell Cycle 15 (4), 506-518, 2016 | 37 | 2016 |
| dDYRK2 and Minibrain interact with the chromatin remodelling factors SNR1 and TRX R Kinstrie, PA Lochhead, G Sibbet, N Morrice, V Cleghon Biochemical Journal 398 (1), 45-54, 2006 | 35 | 2006 |
| CDK1, not ERK1/2 or ERK5, is required for mitotic phosphorylation of BIMEL R Gilley, PA Lochhead, K Balmanno, D Oxley, J Clark, SJ Cook Cellular Signalling 24 (1), 170-180, 2012 | 28 | 2012 |
| Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome AL Ashford, TPJ Dunkley, M Cockerill, RA Rowlinson, LM Baak, R Gallo, ... Cellular and Molecular Life Sciences 73, 883-900, 2016 | 27 | 2016 |
| Small molecule ERK5 kinase inhibitors paradoxically activate ERK5 signalling: be careful what you wish for… SJ Cook, JA Tucker, PA Lochhead Biochemical Society Transactions 48 (5), 1859-1875, 2020 | 24 | 2020 |
| Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4 SM Myers, DC Miller, L Molyneux, M Arasta, RH Bawn, TJ Blackburn, ... European Journal of Medicinal Chemistry 178, 530-543, 2019 | 22 | 2019 |
| Antagonistic effects of phorbol esters on insulin regulation of insulin-like growth factor-binding protein-1 (IGFBP-1) but not glucose-6-phosphatase gene expression S Patel, PA Lochhead, G Rena, C Sutherland Biochemical Journal 359 (3), 611-619, 2001 | 16 | 2001 |
