| Role of phosphate chain mobility of MgATP in completing the 3-phosphoglycerate kinase catalytic site: binding, kinetic, and crystallographic studies with ATP and MgATP B Flachner, Z Kovári, A Varga, Z Gugolya, F Vonderviszt, G Náray-Szabó, ... Biochemistry 43 (12), 3436-3449, 2004 | 59 | 2004 |
| Inhibition of c-Met with the specific small molecule tyrosine kinase inhibitor SU11274 decreases growth and metastasis formation of experimental human melanoma I Kenessey, M Keszthelyi, Z Kramer, J Berta, A Adám, J Dobos, M Mildner, ... Current cancer drug targets 10 (3), 332-342, 2010 | 47 | 2010 |
| Substrate-induced double sided H-bond network as a means of domain closure in 3-phosphoglycerate kinase A Varga, B Flachner, P Konarev, É Gráczer, J Szabó, D Svergun, ... FEBS letters 580 (11), 2698-2706, 2006 | 37 | 2006 |
| Crystallographic and thiol-reactivity studies on the complex of pig muscle phosphoglycerate kinase with ATP analogues: correlation between nucleotide binding mode and helix … Z Kovári, B Flachner, G Náray-Szabó, M Vas Biochemistry 41 (28), 8796-8806, 2002 | 34 | 2002 |
| Substrate-assisted movement of the catalytic Lys 215 during domain closure: site-directed mutagenesis studies of human 3-phosphoglycerate kinase B Flachner, A Varga, J Szabó, L Barna, I Hajdú, G Gyimesi, P Závodszky, ... Biochemistry 44 (51), 16853-16865, 2005 | 33 | 2005 |
| Target identification and polypharmacology of nutraceuticals G Dormán, B Flachner, I Hajdú, C András Nutraceuticals, 315-343, 2021 | 32 | 2021 |
| Correlation between conformational stability of the ternary enzyme–substrate complex and domain closure of 3‐phosphoglycerate kinase A Varga, B Flachner, E Graczer, S Osváth, AN Szilagyi, M Vas The FEBS journal 272 (8), 1867-1885, 2005 | 32 | 2005 |
| Communication between the nucleotide site and the main molecular hinge of 3-phosphoglycerate kinase J Szabó, A Varga, B Flachner, PV Konarev, DI Svergun, P Závodszky, ... Biochemistry 47 (26), 6735-6744, 2008 | 31 | 2008 |
| Stabilization of β-glucosidase in Aspergillus phoenicis QM 329 pellets B Flachner, A Brumbauer, K Reczey Enzyme and microbial technology 24 (5-6), 362-367, 1999 | 28 | 1999 |
| Combination of 2D/3D ligand-based similarity search in rapid virtual screening from multimillion compound repositories. Selection and biological evaluation of potential PDE4 … K Dobi, I Hajdú, B Flachner, G Fabó, M Szaszkó, M Bognár, C Magyar, ... Molecules 19 (6), 7008-7039, 2014 | 26 | 2014 |
| Nucleotide binding to pig muscle 3-phosphoglycerate kinase in the crystal and in solution: relationship between substrate antagonism and interdomain communication A Merli, AN Szilágyi, B Flachner, GL Rossi, M Vas Biochemistry 41 (1), 111-119, 2002 | 25 | 2002 |
| A chemocentric approach to the identification of cancer targets B Flachner, Z Lörincz, A Carotti, O Nicolotti, P Kuchipudi, N Remez, ... PLoS One 7 (4), e35582, 2012 | 23 | 2012 |
| Structure-based consensus scoring scheme for selecting class A aminergic GPCR fragments ÁA Kelemen, R Kiss, GG Ferenczy, L Kovács, B Flachner, Z Lorincz, ... Journal of Chemical Information and Modeling 56 (2), 412-422, 2016 | 17 | 2016 |
| Interaction of human 3-phosphoglycerate kinase with L-ADP, the mirror image of D-ADP A Varga, J Szabó, B Flachner, B Roy, P Konarev, D Svergun, P Závodszky, ... Biochemical and biophysical research communications 366 (4), 994-1000, 2008 | 17 | 2008 |
| Identification of potential glutaminyl cyclase inhibitors from lead-like libraries by in silico and in vitro fragment-based screening M Szaszkó, I Hajdú, B Flachner, K Dobi, C Magyar, I Simon, Z Lőrincz, ... Molecular diversity 21 (1), 175-186, 2017 | 14 | 2017 |
| Thermodynamic analysis of substrate induced domain closure of 3-phosphoglycerate kinase A Varga, J Szabó, B Flachner, Z Gugolya, F Vonderviszt, P Závodszky, ... FEBS letters 583 (22), 3660-3664, 2009 | 13 | 2009 |
| Rapid identification of potential drug candidates from multi-million compounds’ repositories. combination of 2D similarity search with 3D ligand/structure based methods and in … K Szilágyi, B Flachner, I Hajdú, M Szaszkó, K Dobi, Z Lőrincz, S Cseh, ... Molecules 26 (18), 5593, 2021 | 12 | 2021 |
| Design and selection of novel C1s inhibitors by in silico and in vitro approaches K Szilágyi, I Hajdú, B Flachner, Z Lőrincz, J Balczer, P Gál, P Závodszky, ... Molecules 24 (20), 3641, 2019 | 12 | 2019 |
| Dual inhibitors of AChE and BACE-1 for reducing Aβ in Alzheimer’s disease: from in silico to in vivo N Stern, A Gacs, E Tátrai, B Flachner, I Hajdú, K Dobi, I Bágyi, G Dormán, ... International Journal of Molecular Sciences 23 (21), 13098, 2022 | 11 | 2022 |
| Role of side-chains in the operation of the main molecular hinge of 3-phosphoglycerate kinase J Szabó, A Varga, B Flachner, PV Konarev, DI Svergun, P Závodszky, ... FEBS letters 582 (9), 1335-1340, 2008 | 10 | 2008 |
