| Phenylalanine assembly into toxic fibrils suggests amyloid etiology in phenylketonuria L Adler-Abramovich, L Vaks, O Carny, D Trudler, A Magno, A Caflisch, ... Nature chemical biology 8 (8), 701-706, 2012 | 438 | 2012 |
| Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation H Xian, Y Liu, AR Nilsson, R Gatchalian, TR Crother, WG Tourtellotte, ... Immunity 54 (7), 1463-1477. e11, 2021 | 230 | 2021 |
| Mechanisms of hyperexcitability in Alzheimer’s disease hiPSC-derived neurons and cerebral organoids vs isogenic controls S Ghatak, N Dolatabadi, D Trudler, XT Zhang, Y Wu, M Mohata, ... Elife 8, e50333, 2019 | 181 | 2019 |
| Toll‐like receptors expression and signaling in glia cells in neuro‐amyloidogenic diseases: towards future therapeutic application D Trudler, D Farfara, D Frenkel Mediators of inflammation 2010 (1), 497987, 2010 | 157 | 2010 |
| Low-level laser therapy ameliorates disease progression in a mouse model of Alzheimer’s disease D Farfara, H Tuby, D Trudler, E Doron-Mandel, L Maltz, RJ Vassar, ... Journal of Molecular Neuroscience 55, 430-436, 2015 | 127 | 2015 |
| Astrocytes from old Alzheimer's disease mice are impaired in Aβ uptake and in neuroprotection T Iram, D Trudler, D Kain, S Kanner, R Galron, R Vassar, A Barzilai, ... Neurobiology of disease 96, 84-94, 2016 | 107 | 2016 |
| DJ‐1 deficiency triggers microglia sensitivity to dopamine toward a pro‐inflammatory phenotype that is attenuated by rasagiline D Trudler, O Weinreb, SA Mandel, MBH Youdim, D Frenkel Journal of neurochemistry 129 (3), 434-447, 2014 | 106 | 2014 |
| DJ‐1 deficiency impairs autophagy and reduces alpha‐synuclein phagocytosis by microglia Y Nash, E Schmukler, D Trudler, R Pinkas‐Kramarski, D Frenkel Journal of Neurochemistry 143 (5), 584-594, 2017 | 101 | 2017 |
| Soluble α-synuclein–antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia D Trudler, KL Nazor, YS Eisele, T Grabauskas, N Dolatabadi, J Parker, ... Proceedings of the National Academy of Sciences 118 (15), e2025847118, 2021 | 92 | 2021 |
| Potential therapeutic use of the rosemary diterpene carnosic acid for Alzheimer’s disease, Parkinson’s disease, and long-COVID through NRF2 activation to counteract the NLRP3 … T Satoh, D Trudler, CK Oh, SA Lipton Antioxidants 11 (1), 124, 2022 | 80 | 2022 |
| α-Synuclein oligomers induce glutamate release from astrocytes and excessive extrasynaptic NMDAR activity in neurons, thus contributing to synapse loss D Trudler, S Sanz-Blasco, YS Eisele, S Ghatak, K Bodhinathan, ... Journal of Neuroscience 41 (10), 2264-2273, 2021 | 78 | 2021 |
| γ‐Secretase component presenilin is important for microglia β‐amyloid clearance D Farfara, D Trudler, N Segev‐Amzaleg, R Galron, R Stein, D Frenkel Annals of neurology 69 (1), 170-180, 2011 | 72 | 2011 |
| NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models S Ghatak, N Dolatabadi, R Gao, Y Wu, H Scott, D Trudler, A Sultan, ... Molecular psychiatry 26 (10), 5751-5765, 2021 | 53 | 2021 |
| Preconditioning to mild oxidative stress mediates astroglial neuroprotection in an IL-10-dependent manner N Segev-Amzaleg, D Trudler, D Frenkel Brain, Behavior, and Immunity 30, 176-185, 2013 | 46 | 2013 |
| Naphthoquinone-tyrptophan reduces neurotoxic Aβ* 56 levels and improves cognition in Alzheimer's disease animal model R Scherzer-Attali, D Farfara, I Cooper, A Levin, T Ben-Romano, D Trudler, ... Neurobiology of Disease 46 (3), 663-672, 2012 | 45 | 2012 |
| MEF2D haploinsufficiency downregulates the NRF2 pathway and renders photoreceptors susceptible to light-induced oxidative stress S Nagar, SM Noveral, D Trudler, KM Lopez, SR McKercher, X Han, ... Proceedings of the National Academy of Sciences 114 (20), E4048-E4056, 2017 | 39 | 2017 |
| Mechanistic insight into female predominance in Alzheimer’s disease based on aberrant protein S-nitrosylation of C3 H Yang, C Oh, H Amal, JS Wishnok, S Lewis, E Schahrer, D Trudler, ... Science Advances 8 (50), eade0764, 2022 | 36 | 2022 |
| New insights on Parkinson’s disease genes: the link between mitochondria impairment and neuroinflammation D Trudler, Y Nash, D Frenkel Journal of Neural Transmission 122, 1409-1419, 2015 | 29 | 2015 |
| Parkinson’s disease: what the model systems have taught us so far S Ghatak, D Trudler, N Dolatabadi, R Ambasudhan Journal of genetics 97, 729-751, 2018 | 23 | 2018 |
| Targeted protein S-nitrosylation of ACE2 inhibits SARS-CoV-2 infection C Oh, T Nakamura, N Beutler, X Zhang, J Piña-Crespo, M Talantova, ... Nature chemical biology 19 (3), 275-283, 2023 | 19 | 2023 |
