| CRISPResso2 provides accurate and rapid genome editing sequence analysis K Clement, H Rees, MC Canver, JM Gehrke, R Farouni, JY Hsu, MA Cole, ... Nature biotechnology 37 (3), 224-226, 2019 | 1026 | 2019 |
| Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing BP Kleinstiver, AA Sousa, RT Walton, YE Tak, JY Hsu, K Clement, ... Nature biotechnology 37 (3), 276-282, 2019 | 551 | 2019 |
| Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells J Liao, R Karnik, H Gu, MJ Ziller, K Clement, AM Tsankov, V Akopian, ... Nature genetics 47 (5), 469-478, 2015 | 537 | 2015 |
| Highly efficient therapeutic gene editing of human hematopoietic stem cells Y Wu, J Zeng, BP Roscoe, P Liu, Q Yao, CR Lazzarotto, K Clement, ... Nature medicine 25 (5), 776-783, 2019 | 443 | 2019 |
| An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities JM Gehrke, O Cervantes, MK Clement, Y Wu, J Zeng, DE Bauer, L Pinello, ... Nature biotechnology 36 (10), 977-982, 2018 | 439 | 2018 |
| Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia DA Landau, K Clement, MJ Ziller, P Boyle, J Fan, H Gu, K Stevenson, ... Cancer cell 26 (6), 813-825, 2014 | 382 | 2014 |
| In vivo CRISPR editing with no detectable genome-wide off-target mutations P Akcakaya, ML Bobbin, JA Guo, J Malagon-Lopez, K Clement, SP Garcia, ... Nature 561 (7723), 416-419, 2018 | 338 | 2018 |
| A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs J Choi, S Lee, W Mallard, K Clement, GM Tagliazucchi, H Lim, IY Choi, ... Nature biotechnology 33 (11), 1173-1181, 2015 | 297 | 2015 |
| Gel-free multiplexed reduced representation bisulfite sequencing for large-scale DNA methylation profiling P Boyle, K Clement, H Gu, ZD Smith, M Ziller, JL Fostel, L Holmes, ... Genome biology 13, 1-10, 2012 | 276 | 2012 |
| Assessment of computational methods for the analysis of single-cell ATAC-seq data H Chen, C Lareau, T Andreani, ME Vinyard, SP Garcia, K Clement, ... Genome biology 20, 1-25, 2019 | 261 | 2019 |
| Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells J Choi, AJ Huebner, K Clement, RM Walsh, A Savol, K Lin, H Gu, ... Nature 548 (7666), 219-223, 2017 | 254 | 2017 |
| Therapeutic base editing of human hematopoietic stem cells J Zeng, Y Wu, C Ren, J Bonanno, AH Shen, D Shea, JM Gehrke, ... Nature medicine 26 (4), 535-541, 2020 | 235 | 2020 |
| Epigenetic evolution and lineage histories of chronic lymphocytic leukaemia F Gaiti, R Chaligne, H Gu, RM Brand, S Kothen-Hill, RC Schulman, ... Nature 569 (7757), 576-580, 2019 | 221 | 2019 |
| Genetic determinants and epigenetic effects of pioneer-factor occupancy J Donaghey, S Thakurela, J Charlton, JS Chen, ZD Smith, H Gu, R Pop, ... Nature genetics 50 (2), 250-258, 2018 | 164 | 2018 |
| Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer ZD Smith, J Shi, H Gu, J Donaghey, K Clement, D Cacchiarelli, A Gnirke, ... Nature 549 (7673), 543-547, 2017 | 160 | 2017 |
| CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells K Petri, W Zhang, J Ma, A Schmidts, H Lee, JE Horng, DY Kim, IC Kurt, ... Nature biotechnology 40 (2), 189-193, 2022 | 150 | 2022 |
| Genome-wide tracking of dCas9-methyltransferase footprints C Galonska, J Charlton, AL Mattei, J Donaghey, K Clement, H Gu, ... Nature communications 9 (1), 597, 2018 | 147 | 2018 |
| Cancer-germline antigen expression discriminates clinical outcome to CTLA-4 blockade SA Shukla, P Bachireddy, B Schilling, C Galonska, Q Zhan, C Bango, ... Cell 173 (3), 624-633. e8, 2018 | 137 | 2018 |
| Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells W Li, C Cavelti-Weder, Y Zhang, K Clement, S Donovan, G Gonzalez, ... Nature biotechnology 32 (12), 1223-1230, 2014 | 122 | 2014 |
| The RNA helicase DDX6 controls cellular plasticity by modulating P-body homeostasis B Di Stefano, EC Luo, C Haggerty, S Aigner, J Charlton, J Brumbaugh, ... Cell stem cell 25 (5), 622-638. e13, 2019 | 95 | 2019 |
