New insights into the genetic etiology of Alzheimer’s disease and related dementias C Bellenguez, F Küçükali, IE Jansen, L Kleineidam, S Moreno-Grau, ... Nature genetics 54 (4), 412-436, 2022 | 1481 | 2022 |
An algorithm-based topographical biomaterials library to instruct cell fate HV Unadkat, M Hulsman, K Cornelissen, BJ Papenburg, ... Proceedings of the National Academy of Sciences 108 (40), 16565-16570, 2011 | 438 | 2011 |
Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores I De Rojas, S Moreno-Grau, N Tesi, B Grenier-Boley, V Andrade, ... Nature communications 12 (1), 3417, 2021 | 239 | 2021 |
Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis H Holstege, W Pfeiffer, D Sie, M Hulsman, TJ Nicholas, CC Lee, T Ross, ... Genome research 24 (5), 733-742, 2014 | 206 | 2014 |
Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s disease H Holstege, M Hulsman, C Charbonnier, B Grenier-Boley, O Quenez, ... Nature genetics 54 (12), 1786-1794, 2022 | 132 | 2022 |
Characterization of pathogenic SORL1 genetic variants for association with Alzheimer’s disease: a clinical interpretation strategy H Holstege, SJ Van Der Lee, M Hulsman, TH Wong, JGJ Van Rooij, ... European Journal of Human Genetics 25 (8), 973-981, 2017 | 126 | 2017 |
A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the … SJ Van Der Lee, OJ Conway, I Jansen, MM Carrasquillo, L Kleineidam, ... Acta neuropathologica 138, 237-250, 2019 | 118 | 2019 |
Molecular mechanisms of biomaterial-driven osteogenic differentiation in human mesenchymal stromal cells AMC Barradas, V Monticone, M Hulsman, C Danoux, H Fernandes, ... Integrative biology 5 (7), 920-931, 2013 | 111 | 2013 |
The 100-plus Study of cognitively healthy centenarians: rationale, design and cohort description H Holstege, N Beker, T Dijkstra, K Pieterse, E Wemmenhove, K Schouten, ... European Journal of Epidemiology 33, 1229-1249, 2018 | 89 | 2018 |
Analysis of high-throughput screening reveals the effect of surface topographies on cellular morphology M Hulsman, F Hulshof, H Unadkat, BJ Papenburg, DF Stamatialis, ... Acta biomaterialia 15, 29-38, 2015 | 88 | 2015 |
Mining for osteogenic surface topographies: In silico design to in vivo osseo-integration FFB Hulshof, B Papenburg, A Vasilevich, M Hulsman, Y Zhao, M Levers, ... Biomaterials 137, 49-60, 2017 | 79 | 2017 |
A mesenchymal stromal cell gene signature for donor age H Alves, J Van Ginkel, N Groen, M Hulsman, A Mentink, M Reinders, ... Public Library of Science 7 (8), e42908, 2012 | 78 | 2012 |
New insights on the genetic etiology of Alzheimer’s and related dementia C Bellenguez, F Küçükali, I Jansen, V Andrade, S Moreno-Grau, N Amin, ... MedRxiv, 2020.10. 01.20200659, 2020 | 74 | 2020 |
Centenarian controls increase variant effect sizes by an average twofold in an extreme case–extreme control analysis of Alzheimer’s disease N Tesi, SJ van der Lee, M Hulsman, IE Jansen, N Stringa, N van Schoor, ... European Journal of Human Genetics 27 (2), 244-253, 2019 | 65 | 2019 |
Hi-C chromatin interaction networks predict co-expression in the mouse cortex S Babaei, A Mahfouz, M Hulsman, BPF Lelieveldt, J de Ridder, ... PLoS computational biology 11 (5), e1004221, 2015 | 57 | 2015 |
Neuropathology and cognitive performance in self-reported cognitively healthy centenarians AB Ganz, N Beker, M Hulsman, S Sikkes, NB Bank, P Scheltens, AB Smit, ... Acta neuropathologica communications 6, 1-13, 2018 | 56 | 2018 |
Predicting the therapeutic efficacy of MSC in bone tissue engineering using the molecular marker CADM1 A Mentink, M Hulsman, N Groen, R Licht, KJ Dechering, J van der Stok, ... Biomaterials 34 (19), 4592-4601, 2013 | 56 | 2013 |
PLCG2 protective variant p.P522R modulates tau pathology and disease progression in patients with mild cognitive impairment L Kleineidam, V Chouraki, T Próchnicki, SJ van Der Lee, ... Acta neuropathologica 139, 1025-1044, 2020 | 55 | 2020 |
Association of cognitive function trajectories in centenarians with postmortem neuropathology, physical health, and other risk factors for cognitive decline N Beker, A Ganz, M Hulsman, T Klausch, BA Schmand, P Scheltens, ... JAMA network open 4 (1), e2031654-e2031654, 2021 | 54 | 2021 |
Longitudinal maintenance of cognitive health in centenarians in the 100-plus study N Beker, SAM Sikkes, M Hulsman, N Tesi, SJ van der Lee, P Scheltens, ... JAMA network open 3 (2), e200094-e200094, 2020 | 52 | 2020 |