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Naomi Coombes
Naomi Coombes
UKHSA
在 phe.gov.uk 的电子邮件经过验证
标题
引用次数
引用次数
年份
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK
M Voysey, SAC Clemens, SA Madhi, LY Weckx, PM Folegatti, PK Aley, ...
The Lancet 397 (10269), 99-111, 2021
53842021
Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial
PM Folegatti, KJ Ewer, PK Aley, B Angus, S Becker, ...
The Lancet 396 (10249), 467-478, 2020
27932020
Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial
MN Ramasamy, AM Minassian, KJ Ewer, AL Flaxman, PM Folegatti, ...
The Lancet 396 (10267), 1979-1993, 2020
16882020
Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four …
M Voysey, SAC Clemens, SA Madhi, LY Weckx, PM Folegatti, PK Aley, ...
The Lancet 397 (10277), 881-891, 2021
13562021
Evidence of escape of SARS-CoV-2 variant B. 1.351 from natural and vaccine-induced sera
D Zhou, W Dejnirattisai, P Supasa, C Liu, AJ Mentzer, HM Ginn, Y Zhao, ...
Cell 184 (9), 2348-2361. e6, 2021
11452021
Reduced neutralization of SARS-CoV-2 B. 1.1. 7 variant by convalescent and vaccine sera
P Supasa, D Zhou, W Dejnirattisai, C Liu, AJ Mentzer, HM Ginn, Y Zhao, ...
Cell 184 (8), 2201-2211. e7, 2021
4912021
Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2
J Huo, A Le Bas, RR Ruza, HME Duyvesteyn, H Mikolajek, T Malinauskas, ...
Nature structural & molecular biology 27 (9), 846-854, 2020
4892020
Neutralization of SARS-CoV-2 by destruction of the prefusion spike
J Huo, Y Zhao, J Ren, D Zhou, HME Duyvesteyn, HM Ginn, L Carrique, ...
Cell host & microbe 28 (3), 445-454. e6, 2020
3722020
Quantification of SARS-CoV-2 neutralizing antibody by wild-type plaque reduction neutralization, microneutralization and pseudotyped virus neutralization assays
KR Bewley, NS Coombes, L Gagnon, L McInroy, N Baker, I Shaik, ...
Nature protocols 16 (6), 3114-3140, 2021
2432021
Dose-dependent response to infection with SARS-CoV-2 in the ferret model and evidence of protective immunity
KA Ryan, KR Bewley, SA Fotheringham, GS Slack, P Brown, Y Hall, ...
Nature communications 12 (1), 81, 2021
1642021
A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction
M Ejemel, Q Li, S Hou, ZA Schiller, JA Tree, A Wallace, A Amcheslavsky, ...
Nature communications 11 (1), 4198, 2020
1512020
Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19
FJ Salguero, AD White, GS Slack, SA Fotheringham, KR Bewley, ...
Nature Communications 12 (1), 1260, 2021
1272021
Unfractionated heparin inhibits live wild type SARS‐CoV‐2 cell infectivity at therapeutically relevant concentrations
JA Tree, JE Turnbull, KR Buttigieg, MJ Elmore, N Coombes, J Hogwood, ...
British Journal of Pharmacology 178 (3), 626-635, 2021
972021
Synthetic heparan sulfate mimetic pixatimod (PG545) potently inhibits SARS-CoV-2 by disrupting the spike–ACE2 interaction
SE Guimond, CJ Mycroft-West, NS Gandhi, JA Tree, TT Le, CM Spalluto, ...
ACS central science 8 (5), 527-545, 2022
782022
Upregulation of glucose uptake and hexokinase activity of primary human CD4+ T cells in response to infection with HIV-1
M Kavanagh Williamson, N Coombes, F Juszczak, M Athanasopoulos, ...
Viruses 10 (3), 114, 2018
732018
Dose-dependent response to infection with SARS-CoV-2 in the ferret model: evidence of protection to re-challenge
KA Ryan, KR Bewley, SA Fotheringham, P Brown, Y Hall, AC Marriott, ...
BioRxiv, 2020.05. 29.123810, 2020
422020
mRNA vaccination in people over 80 years of age induces strong humoral immune responses against SARS-CoV-2 with cross neutralization of P. 1 Brazilian variant
H Parry, G Tut, R Bruton, S Faustini, C Stephens, P Saunders, C Bentley, ...
Elife 10, e69375, 2021
242021
BNT162b2 vaccination in people over 80 years of age induces strong humoral immune responses with cross neutralisation of P. 1 Brazilian variant
HM Parry, G Tut, S Faustini, C Stephens, P Saunders, C Bentley, ...
222021
Convalescence from prototype SARS-CoV-2 protects Syrian hamsters from disease caused by the Omicron variant
KA Ryan, RJ Watson, KR Bewley, C Burton, O Carnell, BE Cavell, ...
BioRxiv, 2021.12. 24.474081, 2021
172021
Syrian hamster convalescence from prototype SARS-CoV-2 confers measurable protection against the attenuated disease caused by the Omicron variant
KA Ryan, KR Bewley, RJ Watson, C Burton, O Carnell, BE Cavell, ...
PLoS Pathogens 19 (4), e1011293, 2023
102023
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