High-resolution crystal structure of an engineered human β2-adrenergic G protein–coupled receptor V Cherezov, DM Rosenbaum, MA Hanson, SGF Rasmussen, FS Thian, ... science 318 (5854), 1258-1265, 2007 | 4083 | 2007 |
Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists B Wu, EYT Chien, CD Mol, G Fenalti, W Liu, V Katritch, R Abagyan, ... Science 330 (6007), 1066-1071, 2010 | 2106 | 2010 |
Blu-Ice and the Distributed Control System: software for data acquisition and instrument control at macromolecular crystallography beamlines TM McPhillips, SE McPhillips, HJ Chiu, AE Cohen, AM Deacon, PJ Ellis, ... Journal of synchrotron radiation 9 (6), 401-406, 2002 | 1242 | 2002 |
Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA MR Redinbo, L Stewart, P Kuhn, JJ Champoux, WGJ Hol Science 279 (5356), 1504-1513, 1998 | 1152 | 1998 |
A specific cholesterol binding site is established by the 2.8 Å structure of the human β2-adrenergic receptor MA Hanson, V Cherezov, MT Griffith, CB Roth, VP Jaakola, EYT Chien, ... Structure 16 (6), 897-905, 2008 | 1133 | 2008 |
A structural analysis of M protein in coronavirus assembly and morphology BW Neuman, G Kiss, AH Kunding, D Bhella, MF Baksh, S Connelly, ... Journal of structural biology 174 (1), 11-22, 2011 | 1019 | 2011 |
Crystal structure of a lipid G protein–coupled receptor MA Hanson, CB Roth, E Jo, MT Griffith, FL Scott, G Reinhart, H Desale, ... Science 335 (6070), 851-855, 2012 | 802 | 2012 |
Supramolecular architecture of severe acute respiratory syndrome coronavirus revealed by electron cryomicroscopy BW Neuman, BD Adair, C Yoshioka, JD Quispe, G Orca, P Kuhn, ... Journal of virology 80 (16), 7918-7928, 2006 | 549 | 2006 |
Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline SA Lesley, P Kuhn, A Godzik, AM Deacon, I Mathews, A Kreusch, ... Proceedings of the National Academy of Sciences 99 (18), 11664-11669, 2002 | 505 | 2002 |
A rare-cell detector for cancer RT Krivacic, A Ladanyi, DN Curry, HB Hsieh, P Kuhn, DE Bergsrud, ... Proceedings of the National Academy of Sciences 101 (29), 10501-10504, 2004 | 437 | 2004 |
Early detection of cancer D Crosby, S Bhatia, KM Brindle, LM Coussens, C Dive, M Emberton, ... Science 375 (6586), eaay9040, 2022 | 419 | 2022 |
Structure at 0.85 Å resolution of an early protein photocycle intermediate UK Genick, SM Soltis, P Kuhn, IL Canestrelli, ED Getzoff Nature 392 (6672), 206-209, 1998 | 416 | 1998 |
Crystal structure of the 100 kDa arsenite oxidase from Alcaligenes faecalis in two crystal forms at 1.64 Å and 2.03 Å PJ Ellis, T Conrads, R Hille, P Kuhn Structure 9 (2), 125-132, 2001 | 390 | 2001 |
The GPCR Network: a large-scale collaboration to determine human GPCR structure and function RC Stevens, V Cherezov, V Katritch, R Abagyan, P Kuhn, H Rosen, ... Nature reviews Drug discovery 12 (1), 25-34, 2013 | 387 | 2013 |
Fluid biopsy in patients with metastatic prostate, pancreatic and breast cancers D Marrinucci, K Bethel, A Kolatkar, MS Luttgen, M Malchiodi, F Baehring, ... Physical biology 9 (1), 016003, 2012 | 333 | 2012 |
Automation of X-ray crystallography E Abola, P Kuhn, T Earnest, RC Stevens Nature structural biology 7 (11), 973-977, 2000 | 298 | 2000 |
Severe acute respiratory syndrome coronavirus nonstructural protein 2 interacts with a host protein complex involved in mitochondrial biogenesis and intracellular signaling CT Cornillez-Ty, L Liao, JR Yates III, P Kuhn, MJ Buchmeier Journal of virology 83 (19), 10314-10318, 2009 | 294 | 2009 |
Modeling the onset of symptoms of COVID-19 JR Larsen, MR Martin, JD Martin, P Kuhn, JB Hicks Frontiers in public health 8, 551338, 2020 | 262 | 2020 |
Characterization of circulating tumor cell aggregates identified in patients with epithelial tumors EH Cho, M Wendel, M Luttgen, C Yoshioka, D Marrinucci, D Lazar, ... Physical biology 9 (1), 016001, 2012 | 250 | 2012 |
Vasculogenic mimicry in small cell lung cancer SC Williamson, RL Metcalf, F Trapani, S Mohan, J Antonello, B Abbott, ... Nature communications 7 (1), 13322, 2016 | 242 | 2016 |