| Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates BQ Shen, K Xu, L Liu, H Raab, S Bhakta, M Kenrick, KL Parsons-Reponte, ... Nature biotechnology 30 (2), 184-189, 2012 | 1069 | 2012 |
| Calu-3: a human airway epithelial cell line that shows cAMP-dependent Cl-secretion BQ Shen, WE Finkbeiner, JJ Wine, RJ Mrsny, JH Widdicombe American Journal of Physiology-Lung Cellular and Molecular Physiology 266 (5 …, 1994 | 451 | 1994 |
| Vascular endothelial growth factor governs endothelial nitric-oxide synthase expression via a KDR/Flk-1 receptor and a protein kinase C signaling pathway BQ Shen, DY Lee, TF Zioncheck Journal of Biological Chemistry 274 (46), 33057-33063, 1999 | 367 | 1999 |
| Concomitant over‐expression of vascular endothelial growth factor and its receptors in pancreatic cancer J Itakura, T Ishiwata, B Shen, M Kornmann, M Korc International journal of cancer 85 (1), 27-34, 2000 | 301 | 2000 |
| Homologous up-regulation of KDR/Flk-1 receptor expression by vascular endothelial growth factor in vitro BQ Shen, DY Lee, HP Gerber, BA Keyt, N Ferrara, TF Zioncheck Journal of Biological Chemistry 273 (45), 29979-29985, 1998 | 271 | 1998 |
| Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody–drug conjugates in rats CA Boswell, EE Mundo, C Zhang, D Bumbaca, NR Valle, KR Kozak, ... Bioconjugate chemistry 22 (10), 1994-2004, 2011 | 226 | 2011 |
| Characterization of intact antibody–drug conjugates from plasma/serum in vivo by affinity capture capillary liquid chromatography–mass spectrometry K Xu, L Liu, OM Saad, J Baudys, L Williams, D Leipold, B Shen, H Raab, ... Analytical biochemistry 412 (1), 56-66, 2011 | 186 | 2011 |
| Potential mechanisms for thrombocytopenia development with trastuzumab emtansine (T-DM1) H Uppal, E Doudement, K Mahapatra, WC Darbonne, D Bumbaca, ... Clinical Cancer Research 21 (1), 123-133, 2015 | 174 | 2015 |
| Personalized cancer vaccines: clinical landscape, challenges, and opportunities CS Shemesh, JC Hsu, I Hosseini, BQ Shen, A Rotte, P Twomey, S Girish, ... Molecular Therapy 29 (2), 555-570, 2021 | 169 | 2021 |
| Mechanisms of acquired resistance to trastuzumab emtansine in breast cancer cells G Li, J Guo, BQ Shen, DB Yadav, MX Sliwkowski, LM Crocker, JA Lacap, ... Molecular cancer therapeutics 17 (7), 1441-1453, 2018 | 148 | 2018 |
| Catabolic fate and pharmacokinetic characterization of trastuzumab emtansine (T-DM1): an emphasis on preclinical and clinical catabolism BQ Shen, D Bumbaca, O Saad, Q Yue, C V Pastuskovas, ... Current drug metabolism 13 (7), 901-910, 2012 | 136 | 2012 |
| Highly specific off-target binding identified and eliminated during the humanization of an antibody against FGF receptor 4 D Bumbaca, A Wong, E Drake, AE Reyes II, BC Lin, JP Stephan, ... MAbs 3 (4), 376-386, 2011 | 113 | 2011 |
| Site-specific trastuzumab maytansinoid antibody–drug conjugates with improved therapeutic activity through linker and antibody engineering TH Pillow, J Tien, KL Parsons-Reponte, S Bhakta, H Li, LR Staben, G Li, ... Journal of medicinal chemistry 57 (19), 7890-7899, 2014 | 108 | 2014 |
| A mechanistic pharmacokinetic model elucidating the disposition of trastuzumab emtansine (T-DM1), an antibody–drug conjugate (ADC) for treatment of metastatic breast cancer B Bender, DD Leipold, K Xu, BQ Shen, J Tibbitts, LE Friberg The AAPS journal 16, 994-1008, 2014 | 83 | 2014 |
| Vascular endothelial growth factor KDR receptor signaling potentiates tumor necrosis factor-induced tissue factor expression in endothelial cells BQ Shen, DY Lee, KM Cortopassi, LA Damico, TF Zioncheck Journal of Biological Chemistry 276 (7), 5281-5286, 2001 | 80 | 2001 |
| Quantitative cumulative biodistribution of antibodies in mice: effect of modulating binding affinity to the neonatal Fc receptor V Yip, E Palma, DB Tesar, EE Mundo, D Bumbaca, EK Torres, NA Reyes, ... MAbs 6 (3), 689-696, 2014 | 77 | 2014 |
| Chloride secretion and function of serous and mucous cells of human airway glands WE Finkbeiner, BQ Shen, JH Widdicombe American Journal of Physiology-Lung Cellular and Molecular Physiology 267 (2 …, 1994 | 60 | 1994 |
| Exaggerated hypotensive effect of vascular endothelial growth factor in spontaneously hypertensive rats R Yang, AK Ogasawara, TF Zioncheck, Z Ren, GW He, GG DeGuzman, ... Hypertension 39 (3), 815-820, 2002 | 56 | 2002 |
| In vivo activity of novel capecitabine regimens alone and with bevacizumab and oxaliplatin in colorectal cancer xenograft models K Kolinsky, BQ Shen, YE Zhang, J Kohles, U Dugan, TF Zioncheck, ... Molecular cancer therapeutics 8 (1), 75-82, 2009 | 50 | 2009 |
| Maximizing tumour exposure to anti‐neuropilin‐1 antibody requires saturation of non‐tumour tissue antigenic sinks in mice D Bumbaca, H Xiang, CA Boswell, RE Port, SL Stainton, EE Mundo, ... British journal of pharmacology 166 (1), 368-377, 2012 | 46 | 2012 |
