Mutational heterogeneity in cancer and the search for new cancer-associated genes MS Lawrence, P Stojanov, P Polak, GV Kryukov, K Cibulskis, ... Nature 499 (7457), 214-218, 2013 | 5911 | 2013 |
Inactivation of the apoptosis effector Apaf-1 in malignant melanoma MS Soengas, P Capodieci, D Polsky, J Mora, M Esteller, X Opitz-Araya, ... Nature 409 (6817), 207-211, 2001 | 1270 | 2001 |
Intertumoral heterogeneity within medulloblastoma subgroups FMG Cavalli, M Remke, L Rampasek, J Peacock, DJH Shih, B Luu, ... Cancer cell 31 (6), 737-754. e6, 2017 | 1096 | 2017 |
The whole-genome landscape of medulloblastoma subtypes PA Northcott, I Buchhalter, AS Morrissy, V Hovestadt, J Weischenfeldt, ... Nature 547 (7663), 311-317, 2017 | 1001 | 2017 |
Integrated molecular meta-analysis of 1,000 pediatric high-grade and diffuse intrinsic pontine glioma A Mackay, A Burford, D Carvalho, E Izquierdo, J Fazal-Salom, KR Taylor, ... Cancer cell 32 (4), 520-537. e5, 2017 | 911 | 2017 |
Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors JF Shern, L Chen, J Chmielecki, JS Wei, R Patidar, M Rosenberg, ... Cancer discovery 4 (2), 216-231, 2014 | 727 | 2014 |
High TGFβ-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene A Bruna, RS Darken, F Rojo, A Ocaña, S Peñuelas, A Arias, R Paris, ... Cancer cell 11 (2), 147-160, 2007 | 591 | 2007 |
Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq MG Filbin, I Tirosh, V Hovestadt, MKL Shaw, LE Escalante, ... Science 360 (6386), 331-335, 2018 | 581 | 2018 |
Atypical teratoid/rhabdoid tumors are comprised of three epigenetic subgroups with distinct enhancer landscapes PD Johann, S Erkek, M Zapatka, K Kerl, I Buchhalter, V Hovestadt, ... Cancer cell 29 (3), 379-393, 2016 | 540 | 2016 |
The genomic landscape of pediatric Ewing sarcoma BD Crompton, C Stewart, A Taylor-Weiner, G Alexe, KC Kurek, ... Cancer discovery 4 (11), 1326-1341, 2014 | 520 | 2014 |
Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma KR Taylor, A Mackay, N Truffaux, YS Butterfield, O Morozova, C Philippe, ... Nature genetics 46 (5), 457-461, 2014 | 510 | 2014 |
A DNA methylation fingerprint of 1628 human samples AF Fernandez, Y Assenov, JI Martin-Subero, B Balint, R Siebert, ... Genome research 22 (2), 407-419, 2012 | 481 | 2012 |
EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas F Mohammad, S Weissmann, B Leblanc, DP Pandey, JW Højfeldt, ... Nature medicine 23 (4), 483-492, 2017 | 479 | 2017 |
Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma JA Perry, A Kiezun, P Tonzi, EM Van Allen, SL Carter, SC Baca, ... Proceedings of the National Academy of Sciences 111 (51), E5564-E5573, 2014 | 446 | 2014 |
A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers RS Lee, C Stewart, SL Carter, L Ambrogio, K Cibulskis, C Sougnez, ... The Journal of clinical investigation 122 (8), 2983-2988, 2012 | 446 | 2012 |
Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis V Ramaswamy, M Remke, E Bouffet, CC Faria, S Perreault, YJ Cho, ... The lancet oncology 14 (12), 1200-1207, 2013 | 408 | 2013 |
Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis EM Thompson, T Hielscher, E Bouffet, M Remke, B Luu, S Gururangan, ... The lancet oncology 17 (4), 484-495, 2016 | 377 | 2016 |
Cytogenetic prognostication within medulloblastoma subgroups DJH Shih, PA Northcott, M Remke, A Korshunov, V Ramaswamy, M Kool, ... Journal of clinical oncology 32 (9), 886-896, 2014 | 363 | 2014 |
Sarcoma classification by DNA methylation profiling C Koelsche, D Schrimpf, D Stichel, M Sill, F Sahm, DE Reuss, M Blattner, ... Nature communications 12 (1), 498, 2021 | 334 | 2021 |
EMP3, a myelin-related gene located in the critical 19q13. 3 region, is epigenetically silenced and exhibits features of a candidate tumor suppressor in glioma and neuroblastoma M Alaminos, V Dávalos, S Ropero, F Setién, MF Paz, M Herranz, ... Cancer research 65 (7), 2565-2571, 2005 | 218 | 2005 |