An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike M Schoof*, B Faust*, RA Saunders*, S Sangwan*, V Rezelj*, N Hoppe, ... Science 370 (6523), 1473-1479, 2020 | 406 | 2020 |
Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq JM Replogle*, RA Saunders*, AN Pogson, JA Hussmann, A Lenail, ... Cell 185 (14), 2559-2575.e28, 2022 | 366 | 2022 |
A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response N Amin-Wetzel*, RA Saunders*, MJ Kamphuis, C Rato, S Preissler, ... Cell 171 (7), 1625-1637. e13, 2017 | 247 | 2017 |
Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs M Jost*, DA Santos*, RA Saunders, MA Horlbeck, JS Hawkins, SM Scaria, ... Nature biotechnology 38 (3), 355-364, 2020 | 143 | 2020 |
Porous titanium bases for osteochondral tissue engineering AB Nover, SL Lee, MS Georgescu, DR Howard, RA Saunders, TY William, ... Acta biomaterialia 27, 286-293, 2015 | 48 | 2015 |
Multistep substrate binding and engagement by the AAA+ ClpXP protease RA Saunders, BM Stinson, TA Baker, RT Sauer Proceedings of the National Academy of Sciences 117 (45), 28005-28013, 2020 | 20 | 2020 |
Repeat-associated non-AUG translation induces cytoplasmic aggregation of CAG repeat-containing RNAs MR Das, Y Chang, R Anderson, RA Saunders, N Zhang, CP Tomberlin, ... Proceedings of the National Academy of Sciences 120 (3), e2215071120, 2023 | 15 | 2023 |
Comparative landscape of genetic dependencies in human and chimpanzee stem cells R She, T Fair, NK Schaefer, RA Saunders, BJ Pavlovic, JS Weissman, ... Cell 186 (14), 2977-2994. e23, 2023 | 12 | 2023 |
Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology G Muthukumar, TA Stevens, AJ Inglis, TK Esantsi, RA Saunders, F Schulte, ... Molecular Cell 84 (6), 1101-1119. e9, 2024 | 2 | 2024 |
A platform for multimodal in vivo pooled genetic screens reveals regulators of liver function RA Saunders, WE Allen, X Pan, J Sandhu, J Lu, TK Lau, K Smolyar, ... bioRxiv, 2024.11. 18.624217, 2024 | | 2024 |
POOLED GENETIC SCREENS WITH RICH READOUTS AT SCALE AND IN VIVO RA Saunders UCSF, 2024 | | 2024 |
Sars-cov2 neutralizing single domain antibody constructs P Walter, A Manglik, M Schoof, B Faust, N Hoppe, R Saunders, ... US Patent App. 17/998,605, 2023 | | 2023 |
Control of mammalian gene dosage using crispr J Weissman, M Jost, MA Horlbeck, D Santos, R Saunders US Patent App. 17/584,176, 2022 | | 2022 |
Flanking sequences regulate the toxicity, non-ATG translation, and aggregation of RNA with tandem CAG Repeats MR Das, Y Chang, R Saunders, N Zhang, C Tomberlin, RD Vale, A Jain bioRxiv, 2021.08. 30.458106, 2021 | | 2021 |