A single autoimmune T cell receptor recognizes more than a million different peptides L Wooldridge, J Ekeruche-Makinde, H Van Den Berg, A Skowera, ... Journal of Biological Chemistry 287 (2), 1168-1177, 2012 | 503 | 2012 |
CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope A Skowera, RJ Ellis, R Varela-Calviño, S Arif, GC Huang, C Van-Krinks, ... The Journal of clinical investigation 118 (10), 3390-3402, 2008 | 459 | 2008 |
Resident CD141 (BDCA3)+ dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation CC Chu, N Ali, P Karagiannis, P Di Meglio, A Skowera, L Napolitano, ... Journal of Experimental Medicine 209 (5), 935-945, 2012 | 305 | 2012 |
Structural basis for the killing of human beta cells by CD8+ T cells in type 1 diabetes AM Bulek, DK Cole, A Skowera, G Dolton, S Gras, F Madura, A Fuller, ... Nature immunology 13 (3), 283-289, 2012 | 215 | 2012 |
Protein kinase inhibitors substantially improve the physical detection of T-cells with peptide-MHC tetramers A Lissina, K Ladell, A Skowera, M Clement, E Edwards, R Seggewiss, ... Journal of immunological methods 340 (1), 11-24, 2009 | 181 | 2009 |
High levels of type 2 cytokine-producing cells in chronic fatigue syndrome A Skowera, A Cleare, D Blair, L Bevis, SC Wessely, M Peakman Clinical & Experimental Immunology 135 (2), 294-302, 2004 | 162 | 2004 |
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity DK Cole, AM Bulek, G Dolton, AJ Schauenberg, B Szomolay, W Rittase, ... The Journal of clinical investigation 126 (6), 2191-2204, 2016 | 160 | 2016 |
Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition DK Cole, ESJ Edwards, KK Wynn, M Clement, JJ Miles, K Ladell, ... The Journal of Immunology 185 (4), 2600-2610, 2010 | 159 | 2010 |
Chronic fatigue syndrome: an update focusing on phenomenology and pathophysiology HJ Cho, A Skowera, A Cleare, S Wessely Current opinion in Psychiatry 19 (1), 67-73, 2006 | 142 | 2006 |
Plasmacytoid dendritic cells are proportionally expanded at diagnosis of type 1 diabetes and enhance islet autoantigen presentation to T-cells through immune complex capture JS Allen, K Pang, A Skowera, R Ellis, C Rackham, B Lozanoska-Ochser, ... Diabetes 58 (1), 138-145, 2009 | 138 | 2009 |
β-Cell–specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure A Skowera, K Ladell, JE McLaren, G Dolton, KK Matthews, E Gostick, ... Diabetes 64 (3), 916-925, 2015 | 136 | 2015 |
Naturally arising human CD4 T-cells that recognize islet autoantigens and secrete interleukin-10 regulate proinflammatory T-cell responses via linked suppression TIM Tree, J Lawson, H Edwards, A Skowera, S Arif, BO Roep, M Peakman Diabetes 59 (6), 1451-1460, 2010 | 121 | 2010 |
Circulating preproinsulin signal peptide–specific CD8 T cells restricted by the susceptibility molecule HLA-A24 are expanded at onset of type 1 diabetes and kill β-cells D Kronenberg, RR Knight, M Estorninho, RJ Ellis, MG Kester, A De Ru, ... Diabetes 61 (7), 1752-1759, 2012 | 119 | 2012 |
Peptide length determines the outcome of TCR/peptide-MHCI engagement J Ekeruche-Makinde, JJ Miles, HA Van Den Berg, A Skowera, DK Cole, ... Blood, The Journal of the American Society of Hematology 121 (7), 1112-1123, 2013 | 116 | 2013 |
Predictors of fatigue following the onset of infectious mononucleosis B Candy, T Chalder, AJ Cleare, A Peakman, A Skowera, S Wessely, ... Psychological medicine 33 (5), 847-855, 2003 | 111 | 2003 |
Comparison of peptide–major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells G Dolton, A Lissina, A Skowera, K Ladell, K Tungatt, E Jones, ... Clinical & Experimental Immunology 177 (1), 47-63, 2014 | 110 | 2014 |
Clinical-grade multipotent adult progenitor cells durably control pathogenic T cell responses in human models of transplantation and autoimmunity JL Reading, JHM Yang, S Sabbah, A Skowera, RR Knight, J Pinxteren, ... The Journal of Immunology 190 (9), 4542-4552, 2013 | 87 | 2013 |
Cellular immune activation in Gulf War veterans A Skowera, M Hotopf, E Sawicka, R Varela-Calvino, C Unwin, V Nikolaou, ... Journal of clinical immunology 24, 66-73, 2004 | 86 | 2004 |
Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity RR Knight, D Kronenberg, M Zhao, GC Huang, M Eichmann, A Bulek, ... Diabetes 62 (1), 205-213, 2013 | 71 | 2013 |
Effector-memory T cells develop in islets and report islet pathology in type 1 diabetes J Chee, HJ Ko, A Skowera, G Jhala, T Catterall, KL Graham, ... The Journal of Immunology 192 (2), 572-580, 2014 | 65 | 2014 |