| Discovery and development of sorafenib: a multikinase inhibitor for treating cancer S Wilhelm, C Carter, M Lynch, T Lowinger, J Dumas, RA Smith, ... Nature reviews Drug discovery 5 (10), 835-844, 2006 | 2093 | 2006 |
| Design and discovery of small molecules targeting raf-1 kinase TB Lowinger, B Riedl, J Dumas, RA Smith Current Pharmaceutical Design 8 (25), 2269-2278, 2002 | 207 | 2002 |
| Peptidyl (acyloxy) methyl ketones and the quiescent affinity label concept: the departing group as a variable structural element in the design of inactivators of cysteine … A Krantz, LJ Copp, PJ Coles, RA Smith, SB Heard Biochemistry 30 (19), 4678-4687, 1991 | 172 | 1991 |
| Discovery of heterocyclic ureas as a new class of raf kinase inhibitors: identification of a second generation lead by a combinatorial chemistry approach RA Smith, J Barbosa, CL Blum, MA Bobko, YV Caringal, R Dally, ... Bioorganic & medicinal chemistry letters 11 (20), 2775-2778, 2001 | 144 | 2001 |
| Efficient. alpha.-halogenation of acyl chlorides by N-bromosuccinimide, N-chlorosuccinimide, and molecular iodine DN Harpp, LQ Bao, CJ Black, JG Gleason, RA Smith The Journal of Organic Chemistry 40 (23), 3420-3427, 1975 | 130 | 1975 |
| Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas S Miller, M Osterhout, J Dumas, U Khire, TB Lowinger, WJ Scott, RA Smith, ... US Patent 7,517,880, 2009 | 124 | 2009 |
| Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas J Dumas, B Riedl, U Khire, JE Wood, RN Sibley, MK Monahan, J Renick, ... US Patent 7,928,239, 2011 | 111 | 2011 |
| Organic sulfur chemistry. 42. Sulfur-sulfur bond cleavage processes. Selective desulfurization of trisulfides DN Harpp, RA Smith Journal of the American Chemical Society 104 (22), 6045-6053, 1982 | 100 | 1982 |
| Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas S Miller, M Osterhout, J Dumas, U Khire, TB Lowinger, WJ Scott, RA Smith, ... US Patent App. 11/932,397, 2009 | 93 | 2009 |
| Substituted pyrazolyl urea derivatives useful in the treatment of cancer W Lee, G Ladouceur, J Dumas, R Smith, S Ying, G Wang, Z Chen, Q Liu, ... US Patent 7,838,524, 2010 | 87 | 2010 |
| Recent advances in the research and development of RAF kinase inhibitors RA Smith, J Dumas, L Adnane, SM Wilhelm Current Topics in Medicinal Chemistry 6 (11), 1071-1089, 2006 | 84 | 2006 |
| New inhibitors of cysteine proteinases. Peptidyl acyloxymethyl ketones and the quiescent nucleofuge strategy RA Smith, LJ Copp, PJ Coles, HW Pauls, VJ Robinson, RW Spencer, ... Journal of the American Chemical Society 110 (13), 4429-4431, 1988 | 84 | 1988 |
| Inhibition of raf kinase using aryl and heteroaryl substituted heterocyclic ureas J Dumas, U Khire, TB Lowinger, B Riedl, WJ Scott, RA Smith, JE Wood, ... US Patent 7,625,915, 2009 | 82 | 2009 |
| Discovery of a new class of p38 kinase inhibitors J Dumas, R Sibley, B Riedl, MK Monahan, W Lee, TB Lowinger, ... Bioorganic & medicinal chemistry letters 10 (18), 2047-2050, 2000 | 79 | 2000 |
| Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas J Dumas, U Khire, TB Lowinger, B Riedl, WJ Scott, RA Smith, JE Wood, ... US Patent App. 12/181,032, 2008 | 77* | 2008 |
| Solid-phase synthesis of a library of piperazinediones and diazepinediones via Kaiser oxime resin RA Smith, MA Bobko, W Lee Bioorganic & medicinal chemistry letters 8 (17), 2369-2374, 1998 | 77 | 1998 |
| Recent developments in the discovery of protein kinase inhibitors from the urea class. J Dumas, RA Smith, TB Lowinger Current Opinion in Drug Discovery & Development 7 (5), 600-616, 2004 | 76 | 2004 |
| ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors B Riedl, J Dumas, U Khire, TB Lowinger, WJ Scott, RA Smith, JE Wood, ... US Patent 8,124,630, 2012 | 75 | 2012 |
| Inhibition of raf kinase using substituted heterocyclic ureas J Dumas, U Khire, T Lowinger, H Paulsen, B Riedl, W Scott, R Smith, ... US Patent App. 11/768,112, 2007 | 75 | 2007 |
| Inhibition of raf kinase activity using aryl ureas JE Wood, H Wild, DH Rogers, J Lyons, M Katz, Y Caringal, R Dally, W Lee, ... US Patent 6,187,799, 2001 | 75 | 2001 |
Timothy B. LowingerCSO, Mersana Therapeutics在 mersana.com 的电子邮件经过验证
