Utilization of halogen bond in lead optimization: a case study of rational design of potent phosphodiesterase type 5 (PDE5) inhibitors Z Xu, Z Liu, T Chen, TT Chen, Z Wang, G Tian, J Shi, X Wang, Y Lu, X Yan, ... Journal of medicinal chemistry 54 (15), 5607-5611, 2011 | 136 | 2011 |
Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2 Y Xie, W Yin, Y Zhang, W Shang, Z Wang, X Luan, G Tian, HA Aisa, Y Xu, ... Cell research 31 (11), 1212-1214, 2021 | 91 | 2021 |
An open, prospective cohort study of VV116 in Chinese participants infected with SARS-CoV-2 omicron variants Y Shen, J Ai, N Lin, H Zhang, Y Li, H Wang, S Wang, Z Wang, T Li, F Sun, ... Emerging microbes & infections 11 (1), 1518-1523, 2022 | 52 | 2022 |
Safety, tolerability, and pharmacokinetics of VV116, an oral nucleoside analog against SARS-CoV-2, in Chinese healthy subjects H Qian, Y Wang, M Zhang, Y Xie, Q Wu, L Liang, Y Cao, H Duan, G Tian, ... Acta Pharmacologica Sinica 43 (12), 3130-3138, 2022 | 51 | 2022 |
Thermodynamic and structural characterization of halogen bonding in protein–ligand interactions: a case study of PDE5 and its inhibitors J Ren, Y He, W Chen, T Chen, G Wang, Z Wang, Z Xu, X Luo, W Zhu, ... Journal of medicinal chemistry 57 (8), 3588-3593, 2014 | 49 | 2014 |
Multiple pharmacophore models combined with molecular docking: a reliable way for efficiently identifying novel PDE4 inhibitors with high structural diversity Z Chen, G Tian, Z Wang, H Jiang, J Shen, W Zhu Journal of chemical information and modeling 50 (4), 615-625, 2010 | 41 | 2010 |
Vesicular glutamate transporter 1 (VGLUT1)-mediated glutamate release and membrane GluA1 activation is involved in the rapid antidepressant-like effects of scopolamine in mice H Yu, M Li, D Zhou, D Lv, Q Liao, Z Lou, M Shen, Z Wang, M Li, X Xiao, ... Neuropharmacology 131, 209-222, 2018 | 39 | 2018 |
Design, synthesis and biological evaluation of novel pyrimidine, 3-cyanopyridine and m-amino-N-phenylbenzamide based monocyclic EGFR tyrosine kinase … Y Mao, W Zhu, X Kong, Z Wang, H Xie, J Ding, NK Terrett, J Shen, J Shen Bioorganic & medicinal chemistry 21 (11), 3090-3104, 2013 | 37 | 2013 |
Automated design and optimization of multitarget schizophrenia drug candidates by deep learning X Tan, X Jiang, Y He, F Zhong, X Li, Z Xiong, Z Li, X Liu, C Cui, Q Zhao, ... European Journal of Medicinal Chemistry 204, 112572, 2020 | 32 | 2020 |
Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5 G Wang, Z Liu, T Chen, Z Wang, H Yang, M Zheng, J Ren, G Tian, X Yang, ... Journal of Medicinal Chemistry 55 (23), 10540-10550, 2012 | 32 | 2012 |
2-Phenylquinazolin-4 (3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6 H Duan, J Zheng, Q Lai, Z Liu, G Tian, Z Wang, J Li, J Shen Bioorganic & medicinal chemistry letters 19 (10), 2777-2779, 2009 | 29 | 2009 |
Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment … Z Wang, X Jiang, X Zhang, G Tian, R Yang, J Wu, X Zou, Z Liu, X Yang, ... Journal of Medicinal Chemistry 62 (10), 4979-4990, 2019 | 26 | 2019 |
Sub-anesthetic and anesthetic ketamine produce different long-lasting behavioral phenotypes (24 h post-treatment) via inducing different brain-derived neurotrophic factor (BDNF … C Wu, Y Wang, Y He, S Wu, Z Xie, J Zhang, J Shen, Z Wang, L He Neurobiology of learning and memory 167, 107136, 2020 | 22 | 2020 |
Targeted drugs for treatment of pulmonary arterial hypertension: past, present, and future perspectives W Zheng, Z Wang, X Jiang, Q Zhao, J Shen Journal of Medicinal Chemistry 63 (24), 15153-15186, 2020 | 21 | 2020 |
GLYX-13 ameliorates schizophrenia-like phenotype induced by MK-801 in mice: role of hippocampal NR2B and DISC1 D Zhou, D Lv, Z Wang, Y Zhang, Z Chen, C Wang Frontiers in Molecular Neuroscience 11, 121, 2018 | 20 | 2018 |
Essential roles of neuropeptide VGF regulated TrkB/mTOR/BICC1 signaling and phosphorylation of AMPA receptor subunit GluA1 in the rapid antidepressant-like actions of ketamine … M Shen, D Lv, X Liu, S Li, Y Chen, Y Zhang, Z Wang, C Wang Brain Research Bulletin 143, 58-65, 2018 | 19 | 2018 |
Synthesis and biological evaluation of a series of multi-target N-substituted cyclic imide derivatives with potential antipsychotic effect M Xu, Y Wang, F Yang, C Wu, Z Wang, B Ye, X Jiang, Q Zhao, J Li, Y Liu, ... European journal of medicinal chemistry 145, 74-85, 2018 | 18 | 2018 |
The selectivity and potency of the new PDE5 inhibitor TPN729MA Z Wang, D Zhu, X Yang, J Li, X Jiang, G Tian, NK Terrett, J Jin, H Wu, ... The journal of sexual medicine 10 (11), 2790-2797, 2013 | 16 | 2013 |
Synthesis and biological investigation of tetrahydropyridopyrimidinone derivatives as potential multireceptor atypical antipsychotics H Xiamuxi, Z Wang, J Li, Y Wang, C Wu, F Yang, X Jiang, Y Liu, Q Zhao, ... Bioorganic & Medicinal Chemistry 25 (17), 4904-4916, 2017 | 15 | 2017 |
Synthesis and biological evaluation of a series of novel pyridinecarboxamides as potential multi-receptor antipsychotic drugs M Xu, Y Wang, F Yang, C Wu, Z Wang, B Ye, X Jiang, Q Zhao, J Li, Y Liu, ... Bioorganic & Medicinal Chemistry Letters 28 (4), 606-611, 2018 | 13 | 2018 |