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APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids J Zhao, Y Fu, Y Yamazaki, Y Ren, MD Davis, CC Liu, W Lu, X Wang, ... Nature communications 11 (1), 5540, 2020 | 221 | 2020 |
Alzheimer’s risk factors age, APOE genotype, and sex drive distinct molecular pathways N Zhao, Y Ren, Y Yamazaki, W Qiao, F Li, LM Felton, ... Neuron 106 (5), 727-742. e6, 2020 | 179 | 2020 |
APOE2: protective mechanism and therapeutic implications for Alzheimer’s disease Z Li, F Shue, N Zhao, M Shinohara, G Bu Molecular neurodegeneration 15 (1), 63, 2020 | 166 | 2020 |
Dentate gyrus contributes to retrieval as well as encoding: evidence from context fear conditioning, recall, and extinction BE Bernier, AF Lacagnina, A Ayoub, F Shue, BV Zemelman, FB Krasne, ... Journal of Neuroscience 37 (26), 6359-6371, 2017 | 159 | 2017 |
APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid N Zhao, ON Attrebi, Y Ren, W Qiao, B Sonustun, YA Martens, ... Science translational medicine 12 (529), eaay1809, 2020 | 114 | 2020 |
Peripheral apoE4 enhances Alzheimer’s pathology and impairs cognition by compromising cerebrovascular function CC Liu, J Zhao, Y Fu, Y Inoue, Y Ren, Y Chen, SV Doss, F Shue, ... Nature neuroscience 25 (8), 1020-1033, 2022 | 89 | 2022 |
Dorsal and ventral hippocampal adult-born neurons contribute to context fear memory KA Huckleberry, F Shue, T Copeland, RA Chitwood, W Yin, MR Drew Neuropsychopharmacology 43 (12), 2487-2496, 2018 | 85 | 2018 |
APOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia CC Liu, ME Murray, X Li, N Zhao, N Wang, MG Heckman, F Shue, ... Science translational medicine 13 (613), eabc9375, 2021 | 50 | 2021 |
Vascular ApoE4 impairs behavior by modulating gliovascular function Y Yamazaki, CC Liu, A Yamazaki, F Shue, YA Martens, Y Chen, W Qiao, ... Neuron 109 (3), 438-447. e6, 2021 | 43 | 2021 |
Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer’s disease Y Inoue, F Shue, G Bu, T Kanekiyo Molecular neurodegeneration 18 (1), 46, 2023 | 42 | 2023 |
Activation of FAK/Rac1/Cdc42‐GTPase signaling ameliorates impaired microglial migration response to Aβ42 in triggering receptor expressed on myeloid cells 2 … Z Rong, B Cheng, L Zhong, X Ye, X Li, L Jia, Y Li, F Shue, N Wang, ... The FASEB Journal 34 (8), 10984-10997, 2020 | 29 | 2020 |
Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination N Wang, M Wang, S Jeevaratnam, C Rosenberg, TC Ikezu, F Shue, ... Molecular neurodegeneration 17 (1), 75, 2022 | 25 | 2022 |
Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease CC Liu, N Wang, Y Chen, Y Inoue, F Shue, Y Ren, M Wang, W Qiao, ... Nature immunology 24 (11), 1854-1866, 2023 | 24 | 2023 |
Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids J Zhao, W Lu, Y Ren, Y Fu, YA Martens, F Shue, MD Davis, X Wang, ... Acta neuropathologica 142 (5), 807-825, 2021 | 24 | 2021 |
A mouse model of stress-enhanced fear learning demonstrates extinction-sensitive and extinction-resistant effects of footshock stress AM Hassien, F Shue, BE Bernier, MR Drew Behavioural brain research 379, 112391, 2020 | 24 | 2020 |
Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology W Qiao, Y Chen, J Zhong, BJ Madden, CM Charlesworth, YA Martens, ... Molecular neurodegeneration 18 (1), 8, 2023 | 8 | 2023 |
LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4 H Oue, Y Yamazaki, W Qiao, C Yuanxin, Y Ren, A Kurti, F Shue, ... JCI insight 8 (7), 2023 | 5 | 2023 |
Preparation of single cell suspensions enriched in mouse brain vascular cells for single-cell RNA sequencing A Yamazaki, F Shue, Y Yamazaki, YA Martens, G Bu, CC Liu STAR protocols 2 (3), 100715, 2021 | 3 | 2021 |
Upregulation of sFRP1 is more profound in female than male 5xFAD mice and positively associated with amyloid pathology JR Macyczko, N Wang, W Lu, S Jeevaratnam, F Shue, Y Martens, CC Liu, ... Journal of Alzheimer's Disease, 1-7, 2023 | 2 | 2023 |