Aldose reductase enzyme and its implication to major health problems of the 21st century P Alexiou, K Pegklidou, M Chatzopoulou, I Nicolaou, VJ Demopoulos Current medicinal chemistry 16 (6), 734-752, 2009 | 277 | 2009 |
RAGE: a multi-ligand receptor unveiling novel insights in health and disease P Alexiou, M Chatzopoulou, K Pegklidou, VJ Demopoulos Current medicinal chemistry 17 (21), 2232-2252, 2010 | 179 | 2010 |
Curcumin analogues as possible anti-proliferative & anti-inflammatory agents AM Katsori, M Chatzopoulou, K Dimas, C Kontogiorgis, A Patsilinakos, ... European journal of medicinal chemistry 46 (7), 2722-2735, 2011 | 115 | 2011 |
Novel aldose reductase inhibitors: a patent survey (2006–present) M Chatzopoulou, P Alexiou, E Kotsampasakou, VJ Demopoulos Expert opinion on therapeutic patents 22 (11), 1303-1323, 2012 | 51 | 2012 |
Development of aldose reductase inhibitors for the treatment of inflammatory disorders M Chatzopoulou, K Pegklidou, N Papastavrou, VJ Demopoulos Expert opinion on drug discovery 8 (11), 1365-1380, 2013 | 48 | 2013 |
Chemical proteomics and phenotypic profiling identifies the aryl hydrocarbon receptor as a molecular target of the utrophin modulator ezutromid IVL Wilkinson, KJ Perkins, H Dugdale, L Moir, A Vuorinen, ... Angewandte Chemie International Edition 59 (6), 2420-2428, 2020 | 43 | 2020 |
Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives IS Vizirianakis, M Chatzopoulou, ID Bonovolias, I Nicolaou, ... Journal of medicinal chemistry 53 (19), 6779-6810, 2010 | 35 | 2010 |
Structure–activity relations on [1-(3, 5-difluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl] phenylmethanone. The effect of methoxy substitution on aldose reductase inhibitory activity … M Chatzopoulou, E Mamadou, M Juskova, C Koukoulitsa, I Nicolaou, ... Bioorganic & medicinal chemistry 19 (4), 1426-1433, 2011 | 29 | 2011 |
Pilot study to quantify palladium impurities in lead-like compounds following commonly used purification techniques M Chatzopoulou, KS Madden, LJ Bromhead, C Greaves, TJ Cogswell, ... ACS Medicinal Chemistry Letters 13 (2), 262-270, 2022 | 27 | 2022 |
From diagnosis to therapy in Duchenne muscular dystrophy A Babbs, M Chatzopoulou, B Edwards, SE Squire, IVL Wilkinson, ... Biochemical Society Transactions 48 (3), 813-821, 2020 | 27 | 2020 |
A biased agonist at immunometabolic receptor GPR84 causes distinct functional effects in macrophages D Lucy, GSD Purvis, L Zeboudj, M Chatzopoulou, C Recio, CJR Bataille, ... ACS Chemical Biology 14 (9), 2055-2064, 2019 | 27 | 2019 |
A fast entry to furanoditerpenoid-based Hedgehog signaling inhibitors: identifying essential structural features M Chatzopoulou, A Antoniou, EN Pitsinos, M Bantzi, SD Koulocheri, ... Organic letters 16 (12), 3344-3347, 2014 | 26 | 2014 |
2-Arylbenzo[d]oxazole Phosphinate Esters as Second-Generation Modulators of Utrophin for the Treatment of Duchenne Muscular Dystrophy A Babbs, A Berg, M Chatzopoulou, KE Davies, SG Davies, B Edwards, ... Journal of Medicinal Chemistry 63 (14), 7880-7891, 2020 | 23 | 2020 |
Decreasing acidity in a series of aldose reductase inhibitors: 2-Fluoro-4-(1H-pyrrol-1-yl) phenol as a scaffold for improved membrane permeation M Chatzopoulou, A Patsilinakos, T Vallianatou, MS Prnova, S Žakelj, ... Bioorganic & Medicinal Chemistry 22 (7), 2194-2207, 2014 | 22 | 2014 |
1-Hydroxypyrazole as a bioisostere of the acetic acid moiety in a series of aldose reductase inhibitors N Papastavrou, M Chatzopoulou, K Pegklidou, I Nicolaou Bioorganic & medicinal chemistry 21 (17), 4951-4957, 2013 | 20 | 2013 |
The Dimroth rearrangement as a probable cause for structural misassignments in imidazo [1, 2-a] pyrimidines: A 15N-labelling study and an easy method for the determination of … M Chatzopoulou, RF Martínez, NJ Willis, TDW Claridge, FX Wilson, ... Tetrahedron 74 (38), 5280-5288, 2018 | 19 | 2018 |
Discovery and mechanism of action studies of 4, 6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy A Vuorinen, IVL Wilkinson, M Chatzopoulou, B Edwards, SE Squire, ... European Journal of Medicinal Chemistry 220, 113431, 2021 | 15 | 2021 |
Enhancing activity and selectivity in a series of pyrrol-1-yl-1-hydroxypyrazole-based aldose reductase inhibitors: the case of trifluoroacetylation N Papastavrou, M Chatzopoulou, J Ballekova, M Cappiello, R Moschini, ... European Journal of Medicinal Chemistry 130, 328-335, 2017 | 15 | 2017 |
Synthesis of SMT022357 enantiomers and in vivo evaluation in a Duchenne muscular dystrophy mouse model A Babbs, A Berg, M Chatzopoulou, KE Davies, SG Davies, B Edwards, ... Tetrahedron 76 (2), 130819, 2020 | 13 | 2020 |
Isolation, Structural Identification, Synthesis, and Pharmacological Profiling of 1,2-trans-Dihydro-1,2-diol Metabolites of the Utrophin Modulator Ezutromid M Chatzopoulou, TDW Claridge, KE Davies, SG Davies, DJ Elsey, E Emer, ... Journal of Medicinal Chemistry 63 (5), 2547-2556, 2019 | 13 | 2019 |