| LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented … AA Koshkin, SK Singh, P Nielsen, VK Rajwanshi, R Kumar, M Meldgaard, ... tetrahedron 54 (14), 3607-3630, 1998 | 1431 | 1998 |
| Phytochemistry of the genus Piper VS Parmar, SC Jain, KS Bisht, R Jain, P Taneja, A Jha, OD Tyagi, ... Phytochemistry 46 (4), 597-673, 1997 | 1401 | 1997 |
| Potent and nontoxic antisense oligonucleotides containing locked nucleic acids C Wahlestedt, P Salmi, L Good, J Kela, T Johnsson, T Hökfelt, ... Proceedings of the National Academy of Sciences 97 (10), 5633-5638, 2000 | 884 | 2000 |
| LNA (locked nucleic acid): high-affinity targeting of complementary RNA and DNA B Vester, J Wengel Biochemistry 43 (42), 13233-13241, 2004 | 854 | 2004 |
| LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition SK Singh, AA Koshkin, J Wengel, P Nielsen Chemical communications, 455-456, 1998 | 829 | 1998 |
| Oligonucleotide analogues J Wengel, P Nielsen US Patent 6,670,461, 2003 | 826 | 2003 |
| Oligonucleotide analogues J Wengel, P Nielsen US Patent 6,794,499, 2004 | 825 | 2004 |
| LNA: a versatile tool for therapeutics and genomics M Petersen, J Wengel Trends in biotechnology 21 (2), 74-81, 2003 | 818 | 2003 |
| Synthetic genetic polymers capable of heredity and evolution VB Pinheiro, AI Taylor, C Cozens, M Abramov, M Renders, S Zhang, ... Science 336 (6079), 341-344, 2012 | 775 | 2012 |
| L-ribo-LNA analogues J Wengel US Patent 7,053,207, 2006 | 682 | 2006 |
| Oligonucleotide analogues J Wengel, P Nielsen US Patent 7,034,133, 2006 | 584 | 2006 |
| Synthesis of 3‘-C- and 4‘-C-Branched Oligodeoxynucleotides and the Development of Locked Nucleic Acid (LNA) J Wengel Accounts of Chemical Research 32 (4), 301-310, 1999 | 566 | 1999 |
| LNA (locked nucleic acid): an RNA mimic forming exceedingly stable LNA: LNA duplexes AA Koshkin, P Nielsen, M Meldgaard, VK Rajwanshi, SK Singh, J Wengel Journal of the American Chemical Society 120 (50), 13252-13253, 1998 | 446 | 1998 |
| A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity JB Bramsen, MB Laursen, AF Nielsen, TB Hansen, C Bus, N Langkjær, ... Nucleic acids research 37 (9), 2867-2881, 2009 | 443 | 2009 |
| Xylo-LNA analogues J Wengel US Patent 7,084,125, 2006 | 402 | 2006 |
| LNA compositions and uses thereof J Wengel, S Kauppinen US Patent 7,060,809, 2006 | 397 | 2006 |
| Oligonucleotide analogues J Wengel, P Nielsen US Patent 7,572,582, 2009 | 334 | 2009 |
| The first analogues of LNA (locked nucleic acids): phosphorothioate-LNA and 2′-thio-LNA R Kumar, SK Singh, AA Koshkin, VK Rajwanshi, M Meldgaard, J Wengel Bioorganic & medicinal chemistry letters 8 (16), 2219-2222, 1998 | 332 | 1998 |
| Locked nucleic acid (LNA) recognition of RNA: NMR solution structures of LNA: RNA hybrids M Petersen, K Bondensgaard, J Wengel, JP Jacobsen Journal of the American Chemical Society 124 (21), 5974-5982, 2002 | 319 | 2002 |
| The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice S Gao, F Dagnaes-Hansen, EJB Nielsen, J Wengel, F Besenbacher, ... Molecular therapy 17 (7), 1225-1233, 2009 | 312 | 2009 |
