| Platform for T lymphocyte genome engineering and in vivo high-throughput screening thereof S Chen, M Dong US Patent 11,926,839, 2024 | | 2024 |
| AAV-mediated delivery of a Sleeping Beauty transposon and an mRNA-encoded transposase for the engineering of therapeutic immune cells L Ye, SZ Lam, L Yang, K Suzuki, Y Zou, Q Lin, Y Zhang, P Clark, L Peng, ... Nature Biomedical Engineering 8 (2), 132-148, 2024 | 6 | 2024 |
| Genome scale CRISPR screens identify actin capping proteins as key modulators of therapeutic responses to radiation and immunotherapy N Verma, PA Renauer, C Dong, S Xin, Q Lin, F Zhang, PM Glazer, S Chen bioRxiv, 2024.01. 14.575614, 2024 | | 2024 |
| Applications of CRISPR technology in cellular immunotherapy X Zhou, PA Renauer, L Zhou, SY Fang, S Chen Immunological Reviews 320 (1), 199-216, 2023 | 4 | 2023 |
| Compositions and methods for engineering and selection of car t cells with desired phenotypes S Chen, X Dai, Y Du, J Park US Patent App. 18/041,504, 2023 | | 2023 |
| CTLA-4 tail fusion enhances CAR-T antitumor immunity X Zhou, H Cao, SY Fang, RD Chow, K Tang, M Majety, M Bai, MB Dong, ... Nature Immunology 24 (9), 1499-1510, 2023 | 8 | 2023 |
| Massively parallel knock-in engineering of human T cells X Dai, JJ Park, Y Du, Z Na, SZ Lam, RD Chow, PA Renauer, J Gu, S Xin, ... Nature Biotechnology 41 (9), 1239-1255, 2023 | 23 | 2023 |
| Immunogenetic metabolomics reveals key enzymes that modulate CAR T-cell metabolism and function P Renauer, JJ Park, M Bai, A Acosta, WH Lee, GH Lin, Y Zhang, X Dai, ... Cancer immunology research 11 (8), 1068-1084, 2023 | 7 | 2023 |
| Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages P Ren, Y Hu, L Peng, L Yang, K Suzuki, Z Fang, M Bai, L Zhou, Y Feng, ... Signal Transduction and Targeted Therapy 8 (1), 281, 2023 | 7 | 2023 |
| Pooled screening with next-generation gene editing tools L Zhou, L Yang, Y Feng, S Chen Current Opinion in Biomedical Engineering, 100479, 2023 | 2 | 2023 |
| Human gene age dating reveals an early and rapid evolutionary construction of the adaptive immune system L Zhang, JJ Park, MB Dong, D Arsala, S Xia, J Chen, D Sosa, JE Atlas, ... Genome Biology and Evolution 15 (5), evad081, 2023 | | 2023 |
| Polyvalent mRNA vaccination elicited potent immune response to monkeypox virus surface antigens Z Fang, VS Monteiro, PA Renauer, X Shang, K Suzuki, X Ling, M Bai, ... Cell Research 33 (5), 407-410, 2023 | 33 | 2023 |
| Immunogenetic metabolomics revealed key enzymes that modulate CAR-T metabolism and function P Renauer, JJ Park, M Bai, A Acosta, WH Lee, GH Lin, Y Zhang, X Dai, ... bioRxiv, 2023 | 2 | 2023 |
| Multiplexed inhibition of immunosuppressive genes with Cas13d for on-demand combinatorial cancer immunotherapy F Zhang, W Guangchuan, R Chow, E He, M Majety, Y Zhang, S Chen bioRxiv, 2023.03. 14.532668, 2023 | 1 | 2023 |
| Machine learning identifies T cell receptor repertoire signatures associated with COVID-19 severity JJ Park, KAV Lee, SZ Lam, KS Moon, Z Fang, S Chen Communications Biology 6 (1), 76, 2023 | 10 | 2023 |
| RAMIHM generates fully human monoclonal antibodies by rapid mRNA immunization of humanized mice and BCR-seq P Ren, L Peng, L Yang, K Suzuki, Z Fang, PA Renauer, Q Lin, M Bai, T Li, ... Cell Chemical Biology, 2023 | 2 | 2023 |
| Cas12a/Cpf1 knock-in mice enable efficient multiplexed immune cell engineering MB Dong, K Tang, X Zhou, J Shen, K Chen, HR Kim, J Zhou, H Cao, ... bioRxiv, 2023.03. 14.532657, 2023 | 3 | 2023 |
| Perturbomics of tumor-infiltrating NK cells L Peng, PA Renauer, L Ye, L Yang, JJ Park, RD Chow, Y Zhang, Q Lin, ... bioRxiv, 2023.03. 14.532653, 2023 | 4 | 2023 |
| Rational design of immune gene therapy combinations via in vivo CRISPR activation screen of tumor microenvironment modulators G Wang, F Zhang, RD Chow, E He, L Zhu, Q Han, S Chen bioRxiv, 2023.03. 14.532665, 2023 | | 2023 |
| Therapeutic immune cell engineering with an mRNA: AAV-Sleeping Beauty composite system L Ye, SZ Lam, L Yang, K Suzuki, Y Zou, Q Lin, Y Zhang, P Clark, L Peng, ... bioRxiv, 2023.03. 14.532651, 2023 | 2 | 2023 |
