Developmental isoform diversity in the human neocortex informs neuropsychiatric risk mechanisms A Patowary, P Zhang, C Jops, CK Vuong, X Ge, K Hou, M Kim, N Gong, ... Science 384 (6698), eadh7688, 2024 | 6* | 2024 |
Admix-kit: an integrated toolkit and pipeline for genetic analyses of admixed populations K Hou, S Gogarten, J Kim, X Hua, JA Dias, Q Sun, Y Wang, T Tan, ... Bioinformatics 40 (4), btae148, 2024 | | 2024 |
Cell-type deconvolution of bulk-blood RNA-seq reveals biological insights into neuropsychiatric disorders T Boltz, T Schwarz, M Bot, K Hou, C Caggiano, S Lapinska, C Duan, ... The American Journal of Human Genetics 111 (2), 323-337, 2024 | | 2024 |
Single locus theory of admixture is insufficient for the study of complex traits in admixed populations H Lee, MH Lee, K Hou, B Pasaniuc, B Han medRxiv, 2023.11. 07.23298201, 2023 | | 2023 |
Genotype error due to low-coverage sequencing induces uncertainty in polygenic scoring E Petter, Y Ding, K Hou, A Bhattacharya, A Gusev, N Zaitlen, B Pasaniuc The American Journal of Human Genetics 110 (8), 1319-1329, 2023 | 1 | 2023 |
Calibrated prediction intervals for polygenic scores across diverse contexts K Hou, Z Xu, Y Ding, A Harpak, B Pasaniuc medRxiv, 2023 | 3 | 2023 |
Polygenic scoring accuracy varies across the genetic ancestry continuum Y Ding, K Hou, Z Xu, A Pimplaskar, E Petter, K Boulier, F Privé, ... Nature 618 (7966), 774-781, 2023 | 86* | 2023 |
Impact of cross-ancestry genetic architecture on GWASs in admixed populations R Mester, K Hou, Y Ding, G Meeks, KS Burch, A Bhattacharya, BM Henn, ... The American Journal of Human Genetics 110 (6), 927-939, 2023 | 6 | 2023 |
Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals K Hou, Y Ding, Z Xu, Y Wu, A Bhattacharya, R Mester, GM Belbin, ... Nature genetics 55 (4), 549-558, 2023 | 51* | 2023 |
Epigenomic and chromosomal architectural reconfiguration in developing human frontal cortex and hippocampus MG Heffel, J Zhou, Y Zhang, DS Lee, K Hou, OP Alonso, K Abuhanna, ... bioRxiv, 2022.10. 07.511350, 2022 | 4 | 2022 |
Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data MJ Zhang, K Hou, KK Dey, S Sakaue, KA Jagadeesh, K Weinand, ... Nature genetics 54 (10), 1572-1580, 2022 | 57 | 2022 |
Powerful eQTL mapping through low-coverage RNA sequencing T Schwarz, T Boltz, K Hou, M Bot, C Duan, LO Loohuis, MP Boks, ... Human Genetics and Genomics Advances 3 (3), 2022 | 9 | 2022 |
Partitioning gene-level contributions to complex-trait heritability by allele frequency identifies disease-relevant genes KS Burch, K Hou, Y Ding, Y Wang, S Gazal, H Shi, B Pasaniuc The American Journal of Human Genetics 109 (4), 692-709, 2022 | 4 | 2022 |
A multi-dimensional integrative scoring framework for predicting functional variants in the human genome X Li, G Yung, H Zhou, R Sun, Z Li, K Hou, MJ Zhang, Y Liu, T Arapoglou, ... The American Journal of Human Genetics 109 (3), 446-456, 2022 | 19 | 2022 |
Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification Y Ding, K Hou, KS Burch, S Lapinska, F Privé, B Vilhjálmsson, ... Nature genetics 54 (1), 30-39, 2022 | 80 | 2022 |
On powerful GWAS in admixed populations K Hou, A Bhattacharya, R Mester, KS Burch, B Pasaniuc Nature genetics 53 (12), 1631-1633, 2021 | 17 | 2021 |
Estimation of regional polygenicity from GWAS provides insights into the genetic architecture of complex traits R Johnson, KS Burch, K Hou, M Paciuc, B Pasaniuc, S Sankararaman PLoS computational biology 17 (10), e1009483, 2021 | 14 | 2021 |
Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization GA Pathak, K Singh, TW Miller-Fleming, FR Wendt, N Ehsan, K Hou, ... Nature communications 12 (1), 4569, 2021 | 64* | 2021 |
Optimized design of single-cell RNA sequencing experiments for cell-type-specific eQTL analysis I Mandric, T Schwarz, A Majumdar, K Hou, L Briscoe, R Perez, ... Nature communications 11 (1), 5504, 2020 | 51 | 2020 |
Efficient variance components analysis across millions of genomes A Pazokitoroudi, Y Wu, KS Burch, K Hou, A Zhou, B Pasaniuc, ... Nature communications 11 (1), 4020, 2020 | 57* | 2020 |