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José Pedro Castro
José Pedro Castro
Assistant Researcher, Harvard Medical School and I3S
在 i3s.up.pt 的电子邮件经过验证
标题
引用次数
年份
A disease similarity approach identifies short-lived Niemann-Pick type C disease mice with accelerated brain aging as a novel mouse model for Alzheimer’s disease and aging research
VA Gujjala, I Klimek, M Abyadeh, A Tyshkovskiy, N Oz, JP Castro, ...
bioRxiv, 2024.04. 19.590328, 2024
2024
Downregulation of mitochondrial metabolism is a driver for fast skeletal muscle loss during mouse aging
R Fernando, AV Shindyapina, M Ost, D Santesmasses, Y Hu, ...
Communications Biology 6 (1), 1240, 2023
12023
Distinct longevity mechanisms across and within species and their association with aging
A Tyshkovskiy, S Ma, AV Shindyapina, S Tikhonov, SG Lee, P Bozaykut, ...
Cell 186 (13), 2929-2949. e20, 2023
382023
Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna
AV Shindyapina, Y Cho, A Kaya, A Tyshkovskiy, JP Castro, A Deik, ...
Science Advances 8 (37), eabo5482, 2022
512022
In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan
R Ribeiro, JC Macedo, M Costa, V Ustiyan, AV Shindyapina, ...
Nature Aging 2 (5), 397-411, 2022
322022
Central acting Hsp10 regulates mitochondrial function, insulin sensitivity and impacts liver metabolism
K Wardelmann, M Rath, JP Castro, S Blümel, M Schell, R Hauffe, ...
Diabetologie und Stoffwechsel 16 (S 01), 2021
2021
Central acting Hsp10 regulates mitochondrial function, fatty acid metabolism, and insulin sensitivity in the hypothalamus
K Wardelmann, M Rath, JP Castro, S Blümel, M Schell, R Hauffe, ...
Antioxidants 10 (5), 711, 2021
132021
Hepatic Wnt1 inducible signaling pathway protein 1 (WISP-1/CCN4) associates with markers of liver fibrosis in severe obesity
O Pivovarova-Ramich, J Loske, S Hornemann, M Markova, N Seebeck, ...
Cells 10 (5), 1048, 2021
152021
Integrative analyses uncover mechanisms by which aging drives B cell lymphoma
JP Castro, AV Shindyapina, A Barbieri, K Ying, OS Strelkova, JA Paulo, ...
bioRxiv, 2021.02. 23.432500, 2021
12021
Aging Predisposes B cells to Malignancy by Activating c-Myc and Perturbing the Genome and Epigenome
J Castro, A Barbieri, J Paulo, O Strelkova, J Sedivy, J Manis, V Gladyshev, ...
Innovation in Aging 5 (Suppl 1), 562, 2021
2021
Sarcopenia–Molecular mechanisms and open questions
P Wiedmer, T Jung, JP Castro, LCD Pomatto, PY Sun, KJA Davies, ...
Ageing research reviews 65, 101200, 2021
2732021
Integrative analysis reveals aged clonal B cells, microenvironment and c-Myc activation in the origin of age-related lymphoma
AV Shindyapina, JP Castro, A Barbieri, OS Strelkova, JA Paulo, ...
Immune Aging Cancer 10 (2021.02), 23.432500, 2021
4*2021
Accumulation of polyubiquitinated proteins: A consequence of early inactivation of the 26S proteasome
S Reeg, JP Castro, M Hugo, T Grune
Free Radical Biology and Medicine 160, 293-302, 2020
62020
COVID‐19 is an emergent disease of aging
D Santesmasses, JP Castro, AA Zenin, AV Shindyapina, ...
Aging cell 19 (10), e13230, 2020
1872020
Low steady-state oxidative stress inhibits adipogenesis by altering mitochondrial dynamics and decreasing cellular respiration
R Fernando, K Wardelmann, S Deubel, R Kehm, T Jung, M Mariotti, ...
Redox Biology 32, 101507, 2020
232020
(In) Fertility and oxidative stress: New insights into novel redox mechanisms controlling fundamental reproductive processes
E Silva, H Almeida, JP Castro
Oxidative Medicine and Cellular Longevity 2020, 2020
152020
Age‐related maintenance of the autophagy‐lysosomal system is dependent on skeletal muscle type
R Fernando, JP Castro, T Flore, S Deubel, T Grune, C Ott
Oxidative Medicine and Cellular Longevity 2020 (1), 4908162, 2020
222020
Reduced oxidative stress and enhanced FGF21 formation in livers of endurance-exercised rats with diet-induced NASH
J Henkel, K Buchheim-Dieckow, JP Castro, T Laeger, K Wardelmann, ...
Nutrients 11 (11), 2709, 2019
222019
Low proteasomal activity in fast skeletal muscle fibers is not associated with increased age-related oxidative damage
R Fernando, C Drescher, S Deubel, T Jung, M Ost, S Klaus, T Grune, ...
Experimental gerontology 117, 45-52, 2019
82019
Impaired proteostasis during skeletal muscle aging
R Fernando, C Drescher, K Nowotny, T Grune, JP Castro
Free Radical Biology and Medicine 132, 58-66, 2019
1092019
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