A disease similarity approach identifies short-lived Niemann-Pick type C disease mice with accelerated brain aging as a novel mouse model for Alzheimer’s disease and aging research VA Gujjala, I Klimek, M Abyadeh, A Tyshkovskiy, N Oz, JP Castro, ... bioRxiv, 2024.04. 19.590328, 2024 | | 2024 |
Downregulation of mitochondrial metabolism is a driver for fast skeletal muscle loss during mouse aging R Fernando, AV Shindyapina, M Ost, D Santesmasses, Y Hu, ... Communications Biology 6 (1), 1240, 2023 | 1 | 2023 |
Distinct longevity mechanisms across and within species and their association with aging A Tyshkovskiy, S Ma, AV Shindyapina, S Tikhonov, SG Lee, P Bozaykut, ... Cell 186 (13), 2929-2949. e20, 2023 | 38 | 2023 |
Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna AV Shindyapina, Y Cho, A Kaya, A Tyshkovskiy, JP Castro, A Deik, ... Science Advances 8 (37), eabo5482, 2022 | 51 | 2022 |
In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan R Ribeiro, JC Macedo, M Costa, V Ustiyan, AV Shindyapina, ... Nature Aging 2 (5), 397-411, 2022 | 32 | 2022 |
Central acting Hsp10 regulates mitochondrial function, insulin sensitivity and impacts liver metabolism K Wardelmann, M Rath, JP Castro, S Blümel, M Schell, R Hauffe, ... Diabetologie und Stoffwechsel 16 (S 01), 2021 | | 2021 |
Central acting Hsp10 regulates mitochondrial function, fatty acid metabolism, and insulin sensitivity in the hypothalamus K Wardelmann, M Rath, JP Castro, S Blümel, M Schell, R Hauffe, ... Antioxidants 10 (5), 711, 2021 | 13 | 2021 |
Hepatic Wnt1 inducible signaling pathway protein 1 (WISP-1/CCN4) associates with markers of liver fibrosis in severe obesity O Pivovarova-Ramich, J Loske, S Hornemann, M Markova, N Seebeck, ... Cells 10 (5), 1048, 2021 | 15 | 2021 |
Integrative analyses uncover mechanisms by which aging drives B cell lymphoma JP Castro, AV Shindyapina, A Barbieri, K Ying, OS Strelkova, JA Paulo, ... bioRxiv, 2021.02. 23.432500, 2021 | 1 | 2021 |
Aging Predisposes B cells to Malignancy by Activating c-Myc and Perturbing the Genome and Epigenome J Castro, A Barbieri, J Paulo, O Strelkova, J Sedivy, J Manis, V Gladyshev, ... Innovation in Aging 5 (Suppl 1), 562, 2021 | | 2021 |
Sarcopenia–Molecular mechanisms and open questions P Wiedmer, T Jung, JP Castro, LCD Pomatto, PY Sun, KJA Davies, ... Ageing research reviews 65, 101200, 2021 | 273 | 2021 |
Integrative analysis reveals aged clonal B cells, microenvironment and c-Myc activation in the origin of age-related lymphoma AV Shindyapina, JP Castro, A Barbieri, OS Strelkova, JA Paulo, ... Immune Aging Cancer 10 (2021.02), 23.432500, 2021 | 4* | 2021 |
Accumulation of polyubiquitinated proteins: A consequence of early inactivation of the 26S proteasome S Reeg, JP Castro, M Hugo, T Grune Free Radical Biology and Medicine 160, 293-302, 2020 | 6 | 2020 |
COVID‐19 is an emergent disease of aging D Santesmasses, JP Castro, AA Zenin, AV Shindyapina, ... Aging cell 19 (10), e13230, 2020 | 187 | 2020 |
Low steady-state oxidative stress inhibits adipogenesis by altering mitochondrial dynamics and decreasing cellular respiration R Fernando, K Wardelmann, S Deubel, R Kehm, T Jung, M Mariotti, ... Redox Biology 32, 101507, 2020 | 23 | 2020 |
(In) Fertility and oxidative stress: New insights into novel redox mechanisms controlling fundamental reproductive processes E Silva, H Almeida, JP Castro Oxidative Medicine and Cellular Longevity 2020, 2020 | 15 | 2020 |
Age‐related maintenance of the autophagy‐lysosomal system is dependent on skeletal muscle type R Fernando, JP Castro, T Flore, S Deubel, T Grune, C Ott Oxidative Medicine and Cellular Longevity 2020 (1), 4908162, 2020 | 22 | 2020 |
Reduced oxidative stress and enhanced FGF21 formation in livers of endurance-exercised rats with diet-induced NASH J Henkel, K Buchheim-Dieckow, JP Castro, T Laeger, K Wardelmann, ... Nutrients 11 (11), 2709, 2019 | 22 | 2019 |
Low proteasomal activity in fast skeletal muscle fibers is not associated with increased age-related oxidative damage R Fernando, C Drescher, S Deubel, T Jung, M Ost, S Klaus, T Grune, ... Experimental gerontology 117, 45-52, 2019 | 8 | 2019 |
Impaired proteostasis during skeletal muscle aging R Fernando, C Drescher, K Nowotny, T Grune, JP Castro Free Radical Biology and Medicine 132, 58-66, 2019 | 109 | 2019 |