De novo generation of multi-target compounds using deep generative chemistry BP Munson, M Chen, A Bogosian, JF Kreisberg, K Licon, R Abagyan, ... Nature Communications 15 (1), 3636, 2024 | 2 | 2024 |
Genome-wide association studies of human and rat BMI converge on synapse, epigenome, and hormone signaling networks SN Wright, BS Leger, SB Rosenthal, SN Liu, T Jia, AS Chitre, ... Cell reports 42 (8), 2023 | 5 | 2023 |
Mapping the common gene networks that underlie related diseases SB Rosenthal, SN Wright, S Liu, C Churas, D Chilin-Fuentes, CH Chen, ... Nature protocols 18 (6), 1745-1759, 2023 | 5 | 2023 |
Multimodal perturbation analyses of cyclin-dependent kinases reveal a network of synthetic lethalities associated with cell-cycle regulation and transcriptional regulation K Ford, BP Munson, SH Fong, R Panwala, WK Chu, J Rainaldi, ... Scientific reports 13 (1), 7678, 2023 | 1 | 2023 |
Predicting clinical drug responses using a few-shot learning-based interpretable AI S Park, A Singhal, E Silva, JF Kreisberg, T Ideker Cancer Research 82 (12_Supplement), 1159-1159, 2022 | | 2022 |
Prediction of therapeutic response via data-driven maps of tumor cell architecture EN Silva, A Singhal, S Park, J Kreisberg, T Ideker Cancer Research 82 (12_Supplement), 636-636, 2022 | | 2022 |
A multi-scale map of cell structure fusing protein images and interactions Y Qin, EL Huttlin, CF Winsnes, ML Gosztyla, L Wacheul, MR Kelly, ... Nature 600 (7889), 536-542, 2021 | 56 | 2021 |
Interpretation of cancer mutations using a multiscale map of protein systems F Zheng, MR Kelly, DJ Ramms, ML Heintschel, K Tao, B Tutuncuoglu, ... Science 374 (6563), eabf3067, 2021 | 40 | 2021 |
A protein interaction landscape of breast cancer M Kim, J Park, M Bouhaddou, K Kim, A Rojc, M Modak, M Soucheray, ... Science 374 (6563), eabf3066, 2021 | 91 | 2021 |
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity DL Swaney, DJ Ramms, Z Wang, J Park, Y Goto, M Soucheray, N Bhola, ... Science 374 (6563), eabf2911, 2021 | 43 | 2021 |
Genetic dissection of complex traits using hierarchical biological knowledge H Tanaka, JF Kreisberg, T Ideker PLoS Computational Biology 17 (9), e1009373, 2021 | 2 | 2021 |
Mutations in iron-sulfur cluster proteins are associated with decreased bladder cancer cell senescence and improved survival outcomes D Patel, F Zheng, M Chen, J Kreisberg, E Silva, T Ideker, K Licon Cancer Research 81 (13_Supplement), 217-217, 2021 | | 2021 |
Systematic mapping of genetic interactions in human cancer cells reveals context dependent cancer signaling pathways SH Fong, BM Kuenzi, J Lee, K Sanchez, A Bojorquez-Gomez, K Ford, ... Cancer Research 81 (13_Supplement), 2133-2133, 2021 | | 2021 |
Predicting drug response and synergy using a deep learning model of human cancer cells BM Kuenzi, J Park, SH Fong, KS Sanchez, J Lee, JF Kreisberg, J Ma, ... Cancer cell 38 (5), 672-684. e6, 2020 | 310 | 2020 |
Quantitative translation of dog-to-human aging by conserved remodeling of the DNA methylome T Wang, J Ma, AN Hogan, S Fong, K Licon, B Tsui, JF Kreisberg, ... Cell systems 11 (2), 176-185. e6, 2020 | 90 | 2020 |
DrugCell: A visible neural network to guide personalized medicine BM Kuenzi, J Park, S Fong, K Sanchez, J Kreisberg, J Ma, T Ideker Cancer Research 80 (16_Supplement), 1925-1925, 2020 | | 2020 |
Using physical, genetic and integrated cancer cell maps to investigate head and neck cancer and breast cancer JF Kreisberg, F Zheng, S Fong, BM Kuenzi, K Ford, D Swaney, M Kim, ... Cancer Research 80 (16_Supplement), 223-223, 2020 | | 2020 |
Mapping cell structure across scales by fusing protein images and interactions Y Qin, CF Winsnes, EL Huttlin, F Zheng, W Ouyang, J Park, A Pitea, ... bioRxiv, 2020.06. 21.163709, 2020 | 6 | 2020 |
Prospecting whole cancer genomes JF Kreisberg, T Ideker, F Meric-Bernstam, G Mills Nature Cancer 1 (3), 273-275, 2020 | | 2020 |
Abstract C006: DrugCell: A visible neural network to guide precision medicine BM Kuenzi, J Park, S Fong, J Kreisberg, T Ideker Molecular Cancer Therapeutics 18 (12_Supplement), C006-C006, 2019 | | 2019 |