Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4 M Yuan, L Peng, D Huang, A Gavin, F Luan, J Tran, Z Feng, X Zhu, ... Structure, 2024 | 1 | 2024 |
Covid-19 antibodies and uses thereof D Sok, J Jardine, E Landais, D Burton, T Rogers, F Zhao, D Huang US Patent App. 17/923,313, 2023 | | 2023 |
Broadening a SARS-CoV-1–neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolution F Zhao, M Yuan, C Keating, N Shaabani, O Limbo, C Joyce, J Woehl, ... Science Signaling 16 (798), eabk3516, 2023 | 13 | 2023 |
Disease in the Pld4thss/thss model of murine lupus requires TLR9 AL Gavin, TR Blane, TC Thinnes, E Gerlt, A Marshak-Rothstein, D Huang, ... Immunohorizons 7 (8), 577-586, 2023 | 2 | 2023 |
B cell receptor modification in b cells JE Voss, R Andrabi, DR Burton, D Huang, A Gonzalez-Martin US Patent App. 16/642,810, 2023 | | 2023 |
Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways F Zhao, C Keating, G Ozorowski, N Shaabani, IM Francino-Urdaniz, ... Iscience 25 (9), 2022 | 7 | 2022 |
Broadly neutralizing antibodies to SARS-related viruses can be readily induced in rhesus macaques W He, M Yuan, S Callaghan, R Musharrafieh, G Song, M Silva, N Beutler, ... Science translational medicine 14 (657), eabl9605, 2022 | 24 | 2022 |
In vivo engineered B cells secrete high titers of broadly neutralizing anti-HIV antibodies in mice AD Nahmad, CR Lazzarotto, N Zelikson, T Kustin, M Tenuta, D Huang, ... Nature biotechnology 40 (8), 1241-1249, 2022 | 39 | 2022 |
Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors, including endolysosomal TLRs and a STING dependent sensing pathway. D Nemazee, L Peng, T Blane, D Huang, A Gavin The Journal of Immunology 208 (1_Supplement), 158.05-158.05, 2022 | | 2022 |
A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection P Zhou, M Yuan, G Song, N Beutler, N Shaabani, D Huang, W He, X Zhu, ... Science translational medicine 14 (637), eabi9215, 2022 | 136 | 2022 |
A pandemic-enabled comparison of discovery platforms demonstrates a naïve antibody library can match the best immune-sourced antibodies F Ferrara, MF Erasmus, S D’Angelo, C Leal-Lopes, AA Teixeira, ... Nature communications 13 (1), 462, 2022 | 28 | 2022 |
Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors AL Gavin, D Huang, TR Blane, TC Thinnes, Y Murakami, R Fukui, ... Nature Communications 12 (1), 5874, 2021 | 30 | 2021 |
Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern H Cho, KK Gonzales-Wartz, D Huang, M Yuan, M Peterson, J Liang, ... Science translational medicine 13 (616), eabj5413, 2021 | 87 | 2021 |
SARS-CoV-2 serology status detected by commercialized platforms distinguishes previous infection and vaccination adaptive immune responses RT Suhandynata, NJ Bevins, JT Tran, D Huang, MA Hoffman, K Lund, ... The journal of applied laboratory medicine 6 (5), 1109-1122, 2021 | 33 | 2021 |
Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants M Yuan, D Huang, CCD Lee, NC Wu, AM Jackson, X Zhu, H Liu, L Peng, ... Science 373 (6556), 818-823, 2021 | 358 | 2021 |
A rapid assay for SARS-CoV-2 neutralizing antibodies that is insensitive to antiretroviral drugs D Huang, JT Tran, L Peng, L Yang, RT Suhandynata, MA Hoffman, ... The Journal of Immunology 207 (1), 344-351, 2021 | 5 | 2021 |
Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection G Song, W He, S Callaghan, F Anzanello, D Huang, J Ricketts, JL Torres, ... Nature communications 12 (1), 2938, 2021 | 284 | 2021 |
A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection H Liu, M Yuan, D Huang, S Bangaru, F Zhao, CCD Lee, L Peng, ... Cell host & microbe 29 (5), 806-818. e6, 2021 | 56 | 2021 |
Diverse immunoglobulin gene usage and convergent epitope targeting in neutralizing antibody responses to SARS-CoV-2 X Zhou, F Ma, J Xie, M Yuan, Y Li, N Shaabani, F Zhao, D Huang, NC Wu, ... Cell reports 35 (6), 2021 | 27 | 2021 |
In-vivo engineering of B cells elicits memory retention and allows for secretion of broadly neutralizing antibodies in mice AD Nahmad, C Lazzarotto, N Zelikson, T Kustin, M Tenuta, D Huang, ... The Journal of Immunology 206 (1_Supplement), 59.14-59.14, 2021 | | 2021 |