| Paullones are potent inhibitors of glycogen synthase kinase‐3β and cyclin‐dependent kinase 5/p25 M Leost, C Schultz, A Link, YZ Wu, J Biernat, EM Mandelkow, JA Bibb, ... European journal of biochemistry 267 (19), 5983-5994, 2000 | 493 | 2000 |
| Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity C Schultz, A Link, M Leost, DW Zaharevitz, R Gussio, EA Sausville, ... Journal of medicinal chemistry 42 (15), 2909-2919, 1999 | 405 | 1999 |
| Structural and mechanistic basis of pre-and posttransfer editing by leucyl-tRNA synthetase TL Lincecum, M Tukalo, A Yaremchuk, RS Mursinna, AM Williams, ... Molecular cell 11 (4), 951-963, 2003 | 281 | 2003 |
| Structure-based design modifications of the paullone molecular scaffold for cyclin-dependent kinase inhibition R Gussio, DW Zaharevitz, CF McGrath, N Pattabiraman, GE Kellog, ... Anti-cancer drug design 15 (1), 53-66, 2000 | 99 | 2000 |
| Neoceptor Concept Based on Molecular Complementarity in GPCRs: A Mutant Adenosine A3 Receptor with Selectively Enhanced Affinity for Amine-Modified … KA Jacobson, ZG Gao, A Chen, D Barak, SA Kim, K Lee, A Link, ... Journal of medicinal chemistry 44 (24), 4125-4136, 2001 | 97 | 2001 |
| N-Acyl-N-alkyl-sulfonamide anchors derived from Kenner’s safety-catch linker: powerful tools in bioorganic and medicinal chemistry P Heidler, A Link Bioorganic & medicinal chemistry 13 (3), 585-599, 2005 | 85 | 2005 |
| Interconnection of sulfides and sulfoxides in medicinal chemistry AS Surur, L Schulig, A Link Archiv der Pharmazie 352 (1), 1800248, 2019 | 76 | 2019 |
| Synthesis of β-and γ-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates T Haemers, J Wiesner, D Gießmann, T Verbrugghen, U Hillaert, ... Bioorganic & medicinal chemistry 16 (6), 3361-3371, 2008 | 76 | 2008 |
| Directed evolution of a halide methyltransferase enables biocatalytic synthesis of diverse SAM analogs Q Tang, CW Grathwol, AS Aslan‐Üzel, S Wu, A Link, IV Pavlidis, ... Angewandte Chemie International Edition 60 (3), 1524-1527, 2021 | 68 | 2021 |
| d-Fused [1]Benzazepines with Selective in Vitro Antitumor Activity: Synthesis and Structure−Activity Relationships A Link, C Kunick Journal of medicinal chemistry 41 (8), 1299-1305, 1998 | 59 | 1998 |
| Supercritical fluid extraction (SFE) of ketamine metabolites from dried urine and on-line quantification by supercritical fluid chromatography and single mass detection (on … R Hofstetter, GM Fassauer, A Link Journal of Chromatography B 1076, 77-83, 2018 | 57 | 2018 |
| Engineering regioselectivity of a P450 monooxygenase enables the synthesis of ursodeoxycholic acid via 7β‐Hydroxylation of lithocholic acid S Grobe, CPS Badenhorst, T Bayer, E Hamnevik, S Wu, CW Grathwol, ... Angewandte Chemie International Edition 60 (2), 753-757, 2021 | 56 | 2021 |
| Towards New Antimalarial Drugs: Synthesis of Non‐Hydrolyzable Phosphate Mimics as Feed for a Predictive QSAR Study on 1‐Deoxy‐D‐xylulose‐5‐phosphate … D Gießmann, P Heidler, T Haemers, S Van Calenbergh, A Reichenberg, ... Chemistry & biodiversity 5 (4), 643-656, 2008 | 56 | 2008 |
| Anti-malarial activity of N6-substituted adenosine derivatives. Part I A Golisade, J Wiesner, C Herforth, H Jomaa, A Link Bioorganic & medicinal chemistry 10 (3), 769-777, 2002 | 56 | 2002 |
| Quantitative chiral and achiral determination of ketamine and its metabolites by LC–MS/MS in human serum, urine and fecal samples M Hasan, R Hofstetter, GM Fassauer, A Link, W Siegmund, S Oswald Journal of Pharmaceutical and Biomedical Analysis 139, 87-97, 2017 | 55 | 2017 |
| Antimalarial activity of N6-substituted adenosine derivatives. Part 3 C Herforth, J Wiesner, P Heidler, S Sanderbrand, S Van Calenbergh, ... Bioorganic & medicinal chemistry 12 (4), 755-762, 2004 | 45 | 2004 |
| DNA‐Binding Ligands from Peptide Libraries Containing Unnatural Amino Acids T Lescrinier, C Hendrix, L Kerremans, J Rozenski, A Link, B Samyn, ... Chemistry–A European Journal 4 (3), 425-433, 1998 | 45 | 1998 |
| Matrix compare analysis discriminates subtle structural differences in a family of novel antiproliferative agents, diaryl-3-hydroxy-2, 3, 3a, 10a-tetrahydrobenzo [b … C Kunick, C Bleeker, C Prühs, F Totzke, C Schächtele, MHG Kubbutat, ... Bioorganic & medicinal chemistry letters 16 (8), 2148-2153, 2006 | 40 | 2006 |
| Ketamine metabolites with antidepressant effects: fast, economical, and eco-friendly enantioselective separation based on supercritical-fluid chromatography (SFC) and single … GM Fassauer, R Hofstetter, M Hasan, S Oswald, C Modeß, W Siegmund, ... Journal of pharmaceutical and biomedical analysis 146, 410-419, 2017 | 39 | 2017 |
| Practical method for the parallel synthesis of 2′-amido-2′-deoxyadenosines A Link, S Van Calenbergh, P Herdewijn Tetrahedron letters 39 (29), 5175-5176, 1998 | 38 | 1998 |
