| Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization A Molliex, J Temirov, J Lee, M Coughlin, AP Kanagaraj, HJ Kim, T Mittag, ... Cell 163 (1), 123-133, 2015 | 2378 | 2015 |
| Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates S Alberti, A Gladfelter, T Mittag Cell 176 (3), 419-434, 2019 | 2048 | 2019 |
| Protein phase separation: a new phase in cell biology S Boeynaems, S Alberti, NL Fawzi, T Mittag, M Polymenidou, F Rousseau, ... Trends in cell biology 28 (6), 420-435, 2018 | 1687 | 2018 |
| G3BP1 is a tunable switch that triggers phase separation to assemble stress granules P Yang, C Mathieu, RM Kolaitis, P Zhang, J Messing, U Yurtsever, Z Yang, ... Cell 181 (2), 325-345. e28, 2020 | 819 | 2020 |
| Valence and patterning of aromatic residues determine the phase behavior of prion-like domains EW Martin, AS Holehouse, I Peran, M Farag, JJ Incicco, A Bremer, ... Science 367 (6478), 694-699, 2020 | 690 | 2020 |
| TIA1 mutations in amyotrophic lateral sclerosis and frontotemporal dementia promote phase separation and alter stress granule dynamics IR Mackenzie, AM Nicholson, M Sarkar, J Messing, MD Purice, C Pottier, ... Neuron 95 (4), 808-816. e9, 2017 | 569 | 2017 |
| Atomic-level characterization of disordered protein ensembles T Mittag, JD Forman-Kay Current opinion in structural biology 17 (1), 3-14, 2007 | 511 | 2007 |
| Protein dynamics and conformational disorder in molecular recognition T Mittag, LE Kay, JD Forman‐Kay Journal of Molecular Recognition: An Interdisciplinary Journal 23 (2), 105-116, 2010 | 462 | 2010 |
| Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor T Mittag, S Orlicky, WY Choy, X Tang, H Lin, F Sicheri, LE Kay, M Tyers, ... Proceedings of the National Academy of Sciences 105 (46), 17772-17777, 2008 | 371 | 2008 |
| A single N‐terminal phosphomimic disrupts TDP‐43 polymerization, phase separation, and RNA splicing A Wang, AE Conicella, HB Schmidt, EW Martin, SN Rhoads, AN Reeb, ... The EMBO journal 37 (5), e97452, 2018 | 341 | 2018 |
| Relationship of Sequence and Phase Separation in Protein Low-Complexity Regions EW Martin, T Mittag Biochemistry 57 (17), 2478-2487, 2018 | 330 | 2018 |
| Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments JJ Bouchard, JH Otero, DC Scott, E Szulc, EW Martin, N Sabri, D Granata, ... Molecular Cell 72 (1), 19-36, 2018 | 318 | 2018 |
| Structure/function implications in a dynamic complex of the intrinsically disordered Sic1 with the Cdc4 subunit of an SCF ubiquitin ligase T Mittag, J Marsh, A Grishaev, S Orlicky, H Lin, F Sicheri, M Tyers, ... Structure 18 (4), 494-506, 2010 | 291 | 2010 |
| A conceptual framework for understanding phase separation and addressing open questions and challenges T Mittag, RV Pappu Molecular cell 82 (12), 2201-2214, 2022 | 265 | 2022 |
| Polyelectrostatic interactions of disordered ligands suggest a physical basis for ultrasensitivity M Borg, T Mittag, T Pawson, M Tyers, JD Forman-Kay, HS Chan Proceedings of the National Academy of Sciences 104 (23), 9650-9655, 2007 | 254 | 2007 |
| From sequence and forces to structure, function, and evolution of intrinsically disordered proteins JD Forman-Kay, T Mittag Structure 21 (9), 1492-1499, 2013 | 250 | 2013 |
| Deciphering how naturally occurring sequence features impact the phase behaviours of disordered prion-like domains A Bremer, M Farag, WM Borcherds, I Peran, EW Martin, RV Pappu, ... Nature Chemistry 14 (2), 196-207, 2022 | 246 | 2022 |
| Sequence Determinants of the Conformational Properties of an Intrinsically Disordered Protein Prior to and upon Multisite Phosphorylation EW Martin, AS Holehouse, CR Grace, A Hughes, RV Pappu, T Mittag Journal of the American Chemical Society 138 (47), 15323-15335, 2016 | 234 | 2016 |
| Conformational switches modulate protein interactions in peptide antibiotic synthetases A Koglin, MR Mofid, F Löhr, B Schäfer, VV Rogov, MM Blum, T Mittag, ... Science 312 (5771), 273-276, 2006 | 212 | 2006 |
| Multiple modes of protein–protein interactions promote RNP granule assembly T Mittag, R Parker Journal of molecular biology 430 (23), 4636-4649, 2018 | 196 | 2018 |
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