The active site cysteine of the proapoptotic protein glyceraldehyde-3-phosphate dehydrogenase is essential in oxidative stress-induced aggregation and cell death H Nakajima, W Amano, A Fujita, A Fukuhara, YT Azuma, F Hata, T Inui, ... Journal of Biological Chemistry 282 (36), 26562-26574, 2007 | 211 | 2007 |
Glyceraldehyde-3-phosphate dehydrogenase aggregate formation participates in oxidative stress-induced cell death H Nakajima, W Amano, T Kubo, A Fukuhara, H Ihara, YT Azuma, H Tajima, ... Journal of Biological Chemistry 284 (49), 34331-34341, 2009 | 150 | 2009 |
Critical role of the automodification of poly (ADP-ribose) polymerase-1 in nuclear factor-κB-dependent gene expression in primary cultured mouse glial cells H Nakajima, H Nagaso, N Kakui, M Ishikawa, T Hiranuma, S Hoshiko Journal of Biological Chemistry 279 (41), 42774-42786, 2004 | 134 | 2004 |
Interleukin-19 protects mice from innate-mediated colonic inflammation YT Azuma, Y Matsuo, M Kuwamura, GD Yancopoulos, DM Valenzuela, ... Inflammatory bowel diseases 16 (6), 1017-1028, 2010 | 133 | 2010 |
Critical role of sulfenic acid formation of thiols in the inactivation of glyceraldehyde-3-phosphate dehydrogenase by nitric oxide T Ishii, O Sunami, H Nakajima, H Nishio, T Takeuchi, F Hata Biochemical pharmacology 58 (1), 133-143, 1999 | 103 | 1999 |
Involvement of heterotrimeric GTP-binding protein and rho protein, but not protein kinase C, in agonist-induced Ca2+ sensitization of skinned muscle of guinea pig vas deferens. A Fujita, T Takeuchi, H Nakajima, H Nishio, F Hata Journal of Pharmacology and Experimental Therapeutics 274 (1), 555-561, 1995 | 101 | 1995 |
PACAP provides colonic protection against dextran sodium sulfate induced colitis YT Azuma, K Hagi, N Shintani, M Kuwamura, H Nakajima, H Hashimoto, ... Journal of cellular physiology 216 (1), 111-119, 2008 | 96 | 2008 |
PPARα contributes to colonic protection in mice with DSS-induced colitis YT Azuma, K Nishiyama, Y Matsuo, M Kuwamura, A Morioka, H Nakajima, ... International immunopharmacology 10 (10), 1261-1267, 2010 | 93 | 2010 |
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) aggregation causes mitochondrial dysfunction during oxidative stress-induced cell death H Nakajima, M Itakura, T Kubo, A Kaneshige, N Harada, T Izawa, ... Journal of Biological Chemistry 292 (11), 4727-4742, 2017 | 90 | 2017 |
A newly synthesized poly (ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3, 5, 7, 8-tetrahydrothiopyrano [4, 3-d]-pyrimidine-4-one]: pharmacological profiles … H Nakajima, N Kakui, K Ohkuma, M Ishikawa, T Hasegawa Journal of Pharmacology and Experimental Therapeutics 312 (2), 472-481, 2005 | 80 | 2005 |
A rapid, targeted, neuron-selective, in vivo knockdown following a single intracerebroventricular injection of a novel chemically modified siRNA in the adult rat brain H Nakajima, T Kubo, Y Semi, M Itakura, M Kuwamura, T Izawa, YT Azuma, ... Journal of biotechnology 157 (2), 326-333, 2012 | 75 | 2012 |
Glyceraldehyde-3-phosphate dehydrogenase aggregates accelerate amyloid-β amyloidogenesis in Alzheimer disease M Itakura, H Nakajima, T Kubo, Y Semi, S Kume, S Higashida, ... Journal of Biological Chemistry 290 (43), 26072-26087, 2015 | 70 | 2015 |
Lipocalin-type prostaglandin D synthase protects against oxidative stress-induced neuronal cell death A Fukuhara, M Yamada, K Fujimori, Y Miyamoto, T Kusumoto, H Nakajima, ... Biochemical Journal 443 (1), 75-84, 2012 | 66 | 2012 |
Nuclear-translocated glyceraldehyde-3-phosphate dehydrogenase promotes poly (ADP-ribose) polymerase-1 activation during oxidative/nitrosative stress in stroke H Nakajima, T Kubo, H Ihara, T Hikida, T Danjo, M Nakatsuji, N Shahani, ... Journal of Biological Chemistry 290 (23), 14493-14503, 2015 | 59 | 2015 |
IL-19 as a potential therapeutic in autoimmune and inflammatory diseases YT Azuma, H Nakajima, T Takeuchi Current pharmaceutical design 17 (34), 3776-3780, 2011 | 54 | 2011 |
Chronic kidney disease after 5/6 nephrectomy disturbs the intestinal microbiota and alters intestinal motility K Nishiyama, K Aono, Y Fujimoto, M Kuwamura, T Okada, H Tokumoto, ... Journal of cellular physiology 234 (5), 6667-6678, 2019 | 48 | 2019 |
Interleukin-19 is a negative regulator of innate immunity and critical for colonic protection YT Azuma, Y Matsuo, H Nakajima, GD Yancopoulos, DM Valenzuela, ... Journal of pharmacological sciences 115 (2), 105-111, 2011 | 46 | 2011 |
Insulin expression in cultured astrocytes and the decrease by amyloid β K Takano, K Koarashi, K Kawabe, M Itakura, H Nakajima, M Moriyama, ... Neurochemistry International 119, 171-177, 2018 | 42 | 2018 |
M2 and M3 muscarinic receptors are involved in enteric nerve-mediated contraction of the mouse ileum: findings obtained with muscarinic-receptor knockout mouse T Takeuchi, K Tanaka, H Nakajima, M Matsui, YT Azuma American Journal of Physiology-Gastrointestinal and Liver Physiology 292 (1 …, 2007 | 40 | 2007 |
Water-soluble ferulic acid derivatives improve amyloid-β-induced neuronal cell death and dysmnesia through inhibition of amyloid-β aggregation M Kikugawa, H Tsutsuki, T Ida, H Nakajima, H Ihara, T Sakamoto Bioscience, biotechnology, and biochemistry 80 (3), 547-553, 2016 | 38 | 2016 |