| PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS JL Dahlin, JWM Nissink, JM Strasser, S Francis, LA Higgins, H Zhou, ... Journal of medicinal chemistry 58 (5), 2091-2113, 2015 | 372 | 2015 |
| iTRAQ reagent-based quantitative proteomic analysis on a linear ion trap mass spectrometer TJ Griffin, H Xie, S Bandhakavi, J Popko, A Mohan, JV Carlis, LA Higgins Journal of proteome research 6 (11), 4200-4209, 2007 | 181 | 2007 |
| Covalent modification of epithelial fatty acid-binding protein by 4-hydroxynonenal in vitro and in vivo: Evidence for a role in antioxidant biology A Bennaars-Eiden, LA Higgins, AV Hertzel, RJ Kapphahn, DA Ferrington, ... Journal of Biological Chemistry 277 (52), 50693-50702, 2002 | 177 | 2002 |
| ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction JM Park, M Seo, CH Jung, D Grunwald, M Stone, NM Otto, E Toso, Y Ahn, ... Autophagy 14 (4), 584-597, 2018 | 153 | 2018 |
| A new mechanistic probe for cytochrome P450: an application of isotope effect profiles JI Manchester, JP Dinnocenzo, Higgins, JP Jones Journal of the American Chemical Society 119 (21), 5069-5070, 1997 | 153 | 1997 |
| Identification of an ADAM17 cleavage region in human CD16 (FcγRIII) and the engineering of a non-cleavable version of the receptor in NK cells Y Jing, Z Ni, J Wu, LA Higgins, TW Markowski, DS Kaufman, B Walcheck PloS one 10 (3), e0121788, 2015 | 139 | 2015 |
| Functional, structural, and chemical changes in myosin associated with hydrogen peroxide treatment of skeletal muscle fibers E Prochniewicz, DA Lowe, DJ Spakowicz, LA Higgins, K O'Conor, ... American Journal of Physiology-Cell Physiology 294 (2), C613-C626, 2008 | 138 | 2008 |
| Re-evaluation of the role of calcium homeostasis endoplasmic reticulum protein (CHERP) in cellular calcium signaling Y Lin-Moshier, PJ Sebastian, LA Higgins, ND Sampson, JE Hewitt, ... Journal of Biological Chemistry 288 (1), 355-367, 2013 | 105 | 2013 |
| Vitamin B6 conjugation to nuclear corepressor RIP140 and its role in gene regulation MDM Huq, NP Tsai, YP Lin, LA Higgins, LN Wei Nature chemical biology 3 (3), 161-165, 2007 | 103 | 2007 |
| Identification of candidate biomarkers in ovarian cancer serum by depletion of highly abundant proteins and differential in‐gel electrophoresis JD Andersen, KLM Boylan, FS Xue, LB Anderson, BA Witthuhn, ... Electrophoresis 31 (4), 599-610, 2010 | 96 | 2010 |
| Quantitative proteomic analysis by iTRAQ® for the identification of candidate biomarkers in ovarian cancer serum KLM Boylan, JD Andersen, LB Anderson, LA Higgins, APN Skubitz Proteome Science 8, 1-9, 2010 | 91 | 2010 |
| iTRAQ is a useful method to screen for membrane-bound proteins differentially expressed in human natural killer cell types TC Lund, LB Anderson, V McCullar, LA Higgins, GH Yun, B Grzywacz, ... Journal of proteome research 6 (2), 644-653, 2007 | 90 | 2007 |
| Relative quantification: characterization of bias, variability and fold changes in mass spectrometry data from iTRAQ-labeled peptides DW Mahoney, TM Therneau, CJ Heppelmann, LA Higgins, LM Benson, ... Journal of proteome research 10 (9), 4325-4333, 2011 | 88 | 2011 |
| T-LAK Cell-originated Protein Kinase (TOPK) Phosphorylation of Prx1 at Ser-32 Prevents UVB-induced Apoptosis in RPMI7951 Melanoma Cells through the Regulation of Prx1 … TA Zykova, F Zhu, TI Vakorina, J Zhang, LA Higgins, DV Urusova, ... Journal of Biological Chemistry 285 (38), 29138-29146, 2010 | 86 | 2010 |
| Designing safer chemicals: predicting the rates of metabolism of halogenated alkanes. H Yin, MW Anders, KR Korzekwa, LA Higgins, KE Thummel, ED Kharasch, ... Proceedings of the National Academy of Sciences 92 (24), 11076-11080, 1995 | 86 | 1995 |
| Proteome of human calcium kidney stones BK Canales, L Anderson, LA Higgins, K Ensrud-Bowlin, KP Roberts, B Wu, ... Urology 76 (4), 1017. e13-1017. e20, 2010 | 85 | 2010 |
| Lymphokine-activated killer T-cell-originated protein kinase phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells TA Zykova, F Zhu, C Lu, LA Higgins, Y Tatsumi, Y Abe, AM Bode, Z Dong Clinical cancer research 12 (23), 6884-6893, 2006 | 82 | 2006 |
| Modified αA crystallin in the retina: altered expression and truncation with aging RJ Kapphahn, CM Ethen, EA Peters, LA Higgins, DA Ferrington Biochemistry 42 (51), 15310-15325, 2003 | 79 | 2003 |
| Quantitative analysis of the murine lipid droplet-associated proteome during diet-induced hepatic steatosis SA Khan, EE Wollaston-Hayden, TW Markowski, LA Higgins, DG Mashek Journal of lipid research 56 (12), 2260-2272, 2015 | 74 | 2015 |
| Posttranslational modifications in the CP43 subunit of photosystem II LB Anderson, M Maderia, AJA Ouellette, C Putnam-Evans, LA Higgins, ... Proceedings of the National Academy of Sciences 99 (23), 14676-14681, 2002 | 69 | 2002 |
