The enolase superfamily: a general strategy for enzyme-catalyzed abstraction of the α-protons of carboxylic acids PC Babbitt, MS Hasson, JE Wedekind, DRJ Palmer, WC Barrett, GH Reed, ... Biochemistry 35 (51), 16489-16501, 1996 | 428 | 1996 |
Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business JE Wedekind, GSC Dance, MP Sowden, HC Smith Trends in Genetics 19 (4), 207-216, 2003 | 406 | 2003 |
Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance AK Ghosh, PR Sridhar, S Leshchenko, AK Hussain, J Li, AY Kovalevsky, ... Journal of Medicinal Chemistry 49 (17), 5252-5261, 2006 | 176 | 2006 |
A carboxylate oxygen of the substrate bridges the magnesium ions at the active site of enolase: structure of the yeast enzyme complexed with the equilibrium mixture of 2 … TM Larsen, JE Wedekind, I Rayment, GH Reed Biochemistry 35 (14), 4349-4358, 1996 | 170 | 1996 |
Crystal structure of a lead-dependent ribozyme revealing metal binding sites relevant to catalysis JE Wedekind, DB McKay Nature structural biology 6 (3), 261-268, 1999 | 156 | 1999 |
Refined crystallographic structure of Pseudomonas aeruginosa exotoxin A and its implications for the molecular mechanism of toxicity JE Wedekind, CB Trame, M Dorywalska, P Koehl, TM Raschke, M McKee, ... Journal of molecular biology 314 (4), 823-837, 2001 | 154 | 2001 |
Comparison of a preQ1 riboswitch aptamer in metabolite-bound and free states with implications for gene regulation JL Jenkins, J Krucinska, RM McCarty, V Bandarian, JE Wedekind Journal of Biological Chemistry 286 (28), 24626-24637, 2011 | 149 | 2011 |
Chelation of Serine 39 to Mg2+ latches a gate at the active site of enolase: Structure of the Bis (Mg2+) Complex of yeast enolase and the intermediate analog … JE Wedekind, RR Poyner, GH Reed, I Rayment Biochemistry 33 (31), 9333-9342, 1994 | 134 | 1994 |
Crystallographic structures of the hammerhead ribozyme: relationship to ribozyme folding and catalysis JE Wedekind, DB McKay Annual review of biophysics and biomolecular structure 27 (1), 475-502, 1998 | 132 | 1998 |
The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1 K Xie, MP Sowden, GSC Dance, AT Torelli, HC Smith, JE Wedekind Proceedings of the National Academy of Sciences 101 (21), 8114-8119, 2004 | 131 | 2004 |
The Structural Basis for Recognition of the PreQ0 Metabolite by an Unusually Small Riboswitch Aptamer Domain*♦ RC Spitale, AT Torelli, J Krucinska, V Bandarian, JE Wedekind Journal of Biological Chemistry 284 (17), 11012-11016, 2009 | 119 | 2009 |
Nanostructures of APOBEC3G support a hierarchical assembly model of high molecular mass ribonucleoprotein particles from dimeric subunits JE Wedekind, R Gillilan, A Janda, J Krucinska, JD Salter, RP Bennett, ... Journal of Biological Chemistry 281 (50), 38122-38126, 2006 | 117 | 2006 |
Structural and mechanistic studies of enolase GH Reed, RR Poyner, TM Larsen, JE Wedekind, I Rayment Current opinion in structural biology 6 (6), 736-743, 1996 | 114 | 1996 |
Three-Dimensional Structure of Galactose-1-Phosphate Uridylyltransferase from Escherichia Coli at 1.8. ANG. Resolution JE Wedekind, PA Frey, I Rayment Biochemistry 34 (35), 11049-11061, 1995 | 110 | 1995 |
Water in the Active Site of an All-RNA Hairpin Ribozyme and Effects of Gua8 Base Variants on the Geometry of Phosphoryl Transfer, J Salter, J Krucinska, S Alam, V Grum-Tokars, JE Wedekind Biochemistry 45 (3), 686-700, 2006 | 105 | 2006 |
Single transcriptional and translational preQ1 riboswitches adopt similar pre-folded ensembles that follow distinct folding pathways into the same ligand-bound … KC Suddala, AJ Rinaldi, J Feng, AM Mustoe, CD Eichhorn, JA Liberman, ... Nucleic acids research 41 (22), 10462-10475, 2013 | 101 | 2013 |
Crystal structure of the leadzyme at 1.8 Å resolution: Metal ion binding and the implications for catalytic mechanism and allo site ion regulation JE Wedekind, DB McKay Biochemistry 42 (32), 9554-9563, 2003 | 100 | 2003 |
The Structure of Nucleotidylated Histidine-166 of Galactose-1-phosphate Uridylyltransferase Provides Insight into Phosphoryl Group Transfer, JE Wedekind, PA Frey, I Rayment Biochemistry 35 (36), 11560-11569, 1996 | 98 | 1996 |
Structure of a class II preQ1 riboswitch reveals ligand recognition by a new fold JA Liberman, M Salim, J Krucinska, JE Wedekind Nature chemical biology 9 (6), 353-355, 2013 | 97 | 2013 |
Ornithine Cyclodeaminase: Structure, Mechanism of Action, and Implications for the μ-Crystallin Family, JL Goodman, S Wang, S Alam, FJ Ruzicka, PA Frey, JE Wedekind Biochemistry 43 (44), 13883-13891, 2004 | 77 | 2004 |