| In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels T Rothgangl, MK Dennis, PJC Lin, R Oka, D Witzigmann, L Villiger, W Qi, ... Nature biotechnology 39 (8), 949-957, 2021 | 239 | 2021 |
| De novo design of protein interactions with learned surface fingerprints P Gainza, S Wehrle, A Van Hall-Beauvais, A Marchand, A Scheck, ... Nature 617 (7959), 176-184, 2023 | 89 | 2023 |
| Structural basis for Cas9 off-target activity M Pacesa, CH Lin, A Cléry, A Saha, PR Arantes, K Bargsten, MJ Irby, ... Cell 185 (22), 4067-4081. e21, 2022 | 68 | 2022 |
| Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor N Stichling, M Suomalainen, JW Flatt, M Schmid, M Pacesa, S Hemmi, ... PLoS pathogens 14 (3), e1006914, 2018 | 68 | 2018 |
| R-loop formation and conformational activation mechanisms of Cas9 M Pacesa, L Loeff, I Querques, LM Muckenfuss, M Sawicka, M Jinek Nature 609 (7925), 191-196, 2022 | 56* | 2022 |
| The PCNA-associated protein PARI negatively regulates homologous recombination via the inhibition of DNA repair synthesis P Burkovics, L Dome, S Juhasz, V Altmannova, M Sebesta, M Pacesa, ... Nucleic acids research 44 (7), 3176-3189, 2016 | 42 | 2016 |
| A structure–function analysis of the yeast Elg1 protein reveals the importance of PCNA unloading in genome stability maintenance K Shemesh, M Sebesta, M Pacesa, S Sau, A Bronstein, O Parnas, ... Nucleic acids research 45 (6), 3189-3203, 2017 | 39* | 2017 |
| Conformational control of Cas9 by CRISPR hybrid RNA-DNA guides mitigates off-target activity in T cells PD Donohoue, M Pacesa, E Lau, B Vidal, MJ Irby, DB Nyer, T Rotstein, ... Molecular Cell 81 (17), 3637-3649. e5, 2021 | 38 | 2021 |
| Esc2 promotes Mus81 complex-activity via its SUMO-like and DNA binding domains M Sebesta, M Urulangodi, B Stefanovie, B Szakal, M Pacesa, M Lisby, ... Nucleic acids research 45 (1), 215-230, 2017 | 29 | 2017 |
| An atlas of protein homo-oligomerization across domains of life H Schweke, M Pacesa, T Levin, CA Goverde, P Kumar, Y Duhoo, ... Cell, 2024 | 27 | 2024 |
| Principles of target DNA cleavage and the role of Mg2+ in the catalysis of CRISPR–Cas9 Ł Nierzwicki, KW East, JM Binz, RV Hsu, M Ahsan, PR Arantes, E Skeens, ... Nature catalysis 5 (10), 912-922, 2022 | 24 | 2022 |
| Small-size recombinant adenoviral hexon protein fragments for the production of virus-type specific antibodies M Pacesa, R Hendrickx, M Bieri, JW Flatt, UF Greber, S Hemmi Virology journal 14 (1), 158, 2017 | 11 | 2017 |
| PAM-flexible genome editing with an engineered chimeric Cas9 L Zhao, SRT Koseki, RA Silverstein, N Amrani, C Peng, C Kramme, ... Nature Communications 14 (1), 6175, 2023 | 10 | 2023 |
| Past, present, and future of CRISPR genome editing technologies M Pacesa, O Pelea, M Jinek Cell 187 (5), 1076-1100, 2024 | 8 | 2024 |
| Computational design of soluble functional analogues of integral membrane proteins CA Goverde, M Pacesa, N Goldbach, LJ Dornfeld, PEM Balbi, ... bioRxiv, 2023.05. 09.540044, 2023 | 8* | 2023 |
| Design of highly functional genome editors by modeling the universe of CRISPR-Cas sequences JA Ruffolo, S Nayfach, J Gallagher, A Bhatnagar, J Beazer, R Hussain, ... bioRxiv, 2024.04. 22.590591, 2024 | 2 | 2024 |
| Computational design of soluble and functional membrane protein analogues CA Goverde, M Pacesa, N Goldbach, LJ Dornfeld, PEM Balbi, ... Nature, 1-10, 2024 | | 2024 |
| Targeting protein-ligand neosurfaces using a generalizable deep learning approach A Marchand, S Buckley, A Schneuing, M Pacesa, P Gainza, E Elizarova, ... bioRxiv, 2024.03. 25.585721, 2024 | | 2024 |
| Structure and dynamics of off-target effects in CRISPR-Cas9 PR Arantes, BP Mitchell, A Saha, L Nierzwicki, M Pacesa, M Jinek, ... Biophysical Journal 122 (3), 190a, 2023 | | 2023 |
| Principles of DNA cleavage in CRISPR-Cas9 M Ahsan, Ł Nierzwicki, KW East, J Binz, RV Hsu, PR Arantes, E Skeens, ... Biophysical Journal 122 (3), 170a, 2023 | | 2023 |
Martin JINEKUniversity of Zurich在 bioc.uzh.ch 的电子邮件经过验证
