Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi LE Cowen, S Lindquist Science 309 (5744), 2185-2189, 2005 | 801 | 2005 |
Regulatory circuitry governing fungal development, drug resistance, and disease RS Shapiro, N Robbins, LE Cowen Microbiology and molecular biology reviews 75 (2), 213-267, 2011 | 708 | 2011 |
Mechanisms of antifungal drug resistance LE Cowen, D Sanglard, SJ Howard, PD Rogers, DS Perlin Cold Spring Harbor perspectives in medicine 5 (7), a019752, 2015 | 628 | 2015 |
Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond Y Lee, E Puumala, N Robbins, LE Cowen Chemical reviews 121 (6), 3390-3411, 2020 | 502 | 2020 |
Antifungal drug resistance: evolution, mechanisms and impact NM Revie, KR Iyer, N Robbins, LE Cowen Current opinion in microbiology 45, 70-76, 2018 | 486 | 2018 |
Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease LE Cowen, SD Singh, JR Köhler, C Collins, AK Zaas, WA Schell, H Aziz, ... Proceedings of the National Academy of Sciences 106 (8), 2818-2823, 2009 | 450 | 2009 |
The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype LE Cowen Nature Reviews Microbiology 6 (3), 187-198, 2008 | 407 | 2008 |
Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin SD Singh, N Robbins, AK Zaas, WA Schell, JR Perfect, LE Cowen PLoS pathogens 5 (7), e1000532, 2009 | 396 | 2009 |
Molecular evolution of antifungal drug resistance N Robbins, T Caplan, LE Cowen Annual review of microbiology 71 (1), 753-775, 2017 | 385 | 2017 |
Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance LE Cowen, WJ Steinbach Eukaryotic cell 7 (5), 747-764, 2008 | 377 | 2008 |
Threats posed by the fungal kingdom to humans, wildlife, and agriculture MC Fisher, SJ Gurr, CA Cuomo, DS Blehert, H Jin, EH Stukenbrock, ... MBio 11 (3), 10.1128/mbio. 00449-20, 2020 | 356 | 2020 |
Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling RS Shapiro, P Uppuluri, AK Zaas, C Collins, H Senn, JR Perfect, ... Current Biology 19 (8), 621-629, 2009 | 355 | 2009 |
Acquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistance AM Selmecki, K Dulmage, LE Cowen, JB Anderson, J Berman PLoS genetics 5 (10), e1000705, 2009 | 353 | 2009 |
PKC Signaling Regulates Drug Resistance of the Fungal Pathogen Candida albicans via Circuitry Comprised of Mkc1, Calcineurin, and Hsp90 SL LaFayette, C Collins, AK Zaas, WA Schell, M Betancourt-Quiroz, ... PLoS pathogens 6 (8), e1001069, 2010 | 342 | 2010 |
Hsp90 governs dispersion and drug resistance of fungal biofilms N Robbins, P Uppuluri, J Nett, R Rajendran, G Ramage, JL Lopez-Ribot, ... PLoS pathogens 7 (9), e1002257, 2011 | 330 | 2011 |
Evolution of Drug Resistance in Experimental Populations of Candida albicans LE Cowen, D Sanglard, D Calabrese, C Sirjusingh, JB Anderson, ... Journal of bacteriology 182 (6), 1515-1522, 2000 | 265 | 2000 |
Global gene deletion analysis exploring yeast filamentous growth O Ryan, RS Shapiro, CF Kurat, D Mayhew, A Baryshnikova, B Chin, ... Science 337 (6100), 1353-1356, 2012 | 245 | 2012 |
Antifungal drugs: the current armamentarium and development of new agents N Robbins, GD Wright, LE Cowen Microbiology spectrum 4 (5), 10.1128/microbiolspec. funk-0002-2016, 2016 | 234 | 2016 |
Global analysis of fungal morphology exposes mechanisms of host cell escape TR O’Meara, AO Veri, T Ketela, B Jiang, T Roemer, LE Cowen Nature communications 6 (1), 6741, 2015 | 228 | 2015 |
Treatment strategies for cryptococcal infection: challenges, advances and future outlook KR Iyer, NM Revie, C Fu, N Robbins, LE Cowen Nature Reviews Microbiology 19 (7), 454-466, 2021 | 204 | 2021 |