| Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS) DS Howland, J Liu, Y She, B Goad, NJ Maragakis, B Kim, J Erickson, ... Proceedings of the National Academy of Sciences 99 (3), 1604-1609, 2002 | 1067 | 2002 |
| Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration BH LaMonte, KE Wallace, BA Holloway, SS Shelly, J Ascaño, M Tokito, ... Neuron 34 (5), 715-727, 2002 | 657 | 2002 |
| Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease K Sathasivam, A Neueder, TA Gipson, C Landles, AC Benjamin, ... Proceedings of the National Academy of Sciences 110 (6), 2366-2370, 2013 | 525 | 2013 |
| Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington’s disease: zQ175 LB Menalled, AE Kudwa, S Miller, J Fitzpatrick, J Watson-Johnson, ... PloS one 7 (12), e49838, 2012 | 440 | 2012 |
| Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice P Langfelder, JP Cantle, D Chatzopoulou, N Wang, F Gao, I Al-Ramahi, ... Nature neuroscience 19 (4), 623-633, 2016 | 370 | 2016 |
| Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models L Menalled, BF El-Khodor, M Patry, M Suárez-Fariñas, SJ Orenstein, ... Neurobiology of disease 35 (3), 319-336, 2009 | 370 | 2009 |
| Modulation of secreted β-amyloid precursor protein and amyloid β-peptide in brain by cholesterol DS Howland, SP Trusko, MJ Savage, AG Reaume, DM Lang, JD Hirsch, ... Journal of Biological Chemistry 273 (26), 16576-16582, 1998 | 347 | 1998 |
| Turnover of amyloid β-protein in mouse brain and acute reduction of its level by phorbol ester MJ Savage, SP Trusko, DS Howland, LR Pinsker, S Mistretta, AG Reaume, ... Journal of Neuroscience 18 (5), 1743-1752, 1998 | 297 | 1998 |
| Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease T Heikkinen, K Lehtimäki, N Vartiainen, J Puoliväli, SJ Hendricks, ... PloS one 7 (12), e50717, 2012 | 257 | 2012 |
| The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington’s disease patients A Neueder, C Landles, R Ghosh, D Howland, RH Myers, RLM Faull, ... Scientific reports 7 (1), 1307, 2017 | 202 | 2017 |
| Enhanced amyloidogenic processing of the β-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a “humanized” Aβ sequence AG Reaume, DS Howland, SP Trusko, MJ Savage, DM Lang, ... Journal of Biological Chemistry 271 (38), 23380-23388, 1996 | 176 | 1996 |
| A transgenic minipig model of Huntington's disease M Baxa, M Hruska-Plochan, S Juhas, P Vodicka, A Pavlok, J Juhasova, ... Journal of Huntington's disease 2 (1), 47-68, 2013 | 146 | 2013 |
| Impaired spinal cord glutamate transport capacity and reduced sensitivity to riluzole in a transgenic superoxide dismutase mutant rat model of amyotrophic lateral sclerosis J Dunlop, HB McIlvain, Y She, DS Howland Journal of Neuroscience 23 (5), 1688-1696, 2003 | 143 | 2003 |
| Myostatin inhibition slows muscle atrophy in rodent models of amyotrophic lateral sclerosis ELF Holzbaur, DS Howland, N Weber, K Wallace, Y She, S Kwak, ... Neurobiology of disease 23 (3), 697-707, 2006 | 129 | 2006 |
| Large genetic animal models of Huntington's disease AJ Morton, DS Howland Journal of Huntington's disease 2 (1), 3-19, 2013 | 124 | 2013 |
| A novel BACHD transgenic rat exhibits characteristic neuropathological features of Huntington disease L Yu-Taeger, E Petrasch-Parwez, AP Osmand, A Redensek, S Metzger, ... Journal of Neuroscience 32 (44), 15426-15438, 2012 | 119 | 2012 |
| A transgenic rat model of Alzheimer's disease with extracellular Aβ deposition DG Flood, YG Lin, DM Lang, SP Trusko, JD Hirsch, MJ Savage, RW Scott, ... Neurobiology of aging 30 (7), 1078-1090, 2009 | 114 | 2009 |
| Functionally distinct isoforms of dynactin are expressed in human neurons. MK Tokito, DS Howland, VM Lee, EL Holzbaur Molecular biology of the cell 7 (8), 1167-1180, 1996 | 104 | 1996 |
| Artificial miRNAs reduce human mutant Huntingtin throughout the striatum in a transgenic sheep model of Huntington's disease EL Pfister, N DiNardo, E Mondo, F Borel, F Conroy, C Fraser, G Gernoux, ... Human gene therapy 29 (6), 663-673, 2018 | 100 | 2018 |
| Antagonist antibodies against GDF-8 FS Walsh, MM Zaleska, DS Howland, L Tchistiakova, R Karim, P Kelley, ... US Patent 7,888,486, 2011 | 81 | 2011 |
