A synthetic antibiotic class overcoming bacterial multidrug resistance MJ Mitcheltree, A Pisipati, EA Syroegin, KJ Silvestre, D Klepacki, ... Nature 599 (7885), 507-512, 2021 | 146 | 2021 |
The l‐Alanosine Gene Cluster Encodes a Pathway for Diazeniumdiolate Biosynthesis TL Ng, ME McCallum, CR Zheng, JX Wang, KJY Wu, EP Balskus ChemBioChem 21 (8), 1155-1160, 2020 | 31 | 2020 |
Genome-encoded ABCF factors implicated in intrinsic antibiotic resistance in Gram-positive bacteria: VmlR2, Ard1 and CplR N Obana, H Takada, C Crowe-McAuliffe, M Iwamoto, AA Egorov, KJY Wu, ... Nucleic Acids Research 51 (9), 4536-4554, 2023 | 20 | 2023 |
Expression of Bacillus subtilis ABCF antibiotic resistance factor VmlR is regulated by RNA polymerase pausing, transcription attenuation, translation attenuation … H Takada, ZF Mandell, H Yakhnin, A Glazyrina, S Chiba, T Kurata, ... Nucleic Acids Research 50 (11), 6174-6189, 2022 | 17 | 2022 |
An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance KJY Wu, BIC Tresco, A Ramkissoon, EV Aleksandrova, EA Syroegin, ... Science 383 (6684), 721-726, 2024 | 12 | 2024 |
Synthetic oxepanoprolinamide iboxamycin is active against Listeria monocytogenes despite the intrinsic resistance mediated by VgaL/Lmo0919 ABCF ATPase T Brodiazhenko, KJ Turnbull, KJY Wu, H Takada, BIC Tresco, T Tenson, ... JAC-antimicrobial resistance 4 (3), dlac061, 2022 | 7 | 2022 |
Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it EV Aleksandrova, KJY Wu, BIC Tresco, EA Syroegin, EE Killeavy, ... Nature Chemical Biology, 1-10, 2024 | 5 | 2024 |
A synthetic antibiotic scaffold effective against multidrug-resistant bacterial pathogens M Mitcheltree, A Pisipati, EA Syroegin, KJ Silvestre, D Klepacki, J Mason, ... | 5 | 2021 |
A method for tritiation of iboxamycin permits measurement of its ribosomal binding KJY Wu, D Klepacki, AS Mankin, AG Myers Bioorganic & Medicinal Chemistry Letters 91, 129364, 2023 | 3 | 2023 |
Synthetic oxepanoprolinamide iboxamycin is highly active against human pathogen Listeria monocytogenes T Brodiazhenko, KJ Turnbull, KJY Wu, H Takada, BIC Tresco, T Tenson, ... bioRxiv, 2022.02. 28.482263, 2022 | 2 | 2022 |
Structural basis of Cfr-mediated antimicrobial resistance and mechanisms for its evasion EV Aleksandrova, KJY Wu, BIC Tresco, EA Syroegin, EE Killeavy, ... bioRxiv, 2023 | 1 | 2023 |
[3+ 2] Dipolar Cycloaddition of a Stabilized Azomethine Ylide and an Electron-Deficient Dipolarophile: Revision of Regioselectivity KJY Wu, AE Benedetto, AG Myers The Journal of organic chemistry 88 (3), 1907-1908, 2023 | 1 | 2023 |
Discovery of a broad-spectrum, fluorinated macrobicyclic antibiotic through chemical synthesis B Tresco, K Wu, A Ramkissoon, E Aleksandrova, M Purdy, D See, R Liu, ... | | 2024 |
Synthetic lincosamides iboxamycin and cresomycin are active against ocular multidrug-resistant methicillin-resistant S. aureus carrying erm genes C André, KJY Wu, AG Myers, PJM Bispo Journal of Global Antimicrobial Resistance, 2024 | | 2024 |
A Synthetic Antibiotic Scaffold Effective Against Multidrug-Resistant Bacterial Pathogens (preprint) M Mitcheltree, A Pisipati, EA Syroegin, KJ Silvestre, D Klepacki, J Mason, ... | | 2021 |